Cancer scientists led by principal investigator Dr. Daniel De Carvalho at Princess Margaret Cancer Centre have combined “liquid biopsy,” epigenetic alterations and machine learning to develop a blood test to detect and classify cancer at its earliest stages.
The findings, published online today in Nature, describe not only a way to detect cancer, but hold promise of being able to find it earlier when it is more easily treated and long before symptoms ever appear, says Dr. De Carvalho, Senior Scientist at the cancer centre, University Health Network.
“We are very excited at this stage,” says Dr. De Carvalho. “A major problem in cancer is how to detect it early. It has been a ‘needle in the haystack’ problem of how to find that one-in-a-billion cancer-specific mutation in the blood, especially at earlier stages, where the amount of tumour DNA in the blood is minimal.”
By profiling epigenetic alterations instead of mutations, the team was able to identify thousands of modifications unique to each cancer type. Then, using a big data approach, they applied machine learning to create classifiers able to identify the presence of cancer-derived DNA within blood samples and to determine what cancer type. This basically turns the “one needle in the haystack” problem into a more solvable “thousands of needles in the haystack,” where the computer just needs to find a few needles to define which haystack has needles.
The scientists tracked the cancer origin and type by comparing 300 patient tumour samples from seven disease sites (lung, pancreatic, colorectal, breast, leukemia, bladder and kidney) and samples from healthy donors with the analysis of cell-free DNA circulating in the blood plasma. In every sample, the “floating” plasma DNA matched the tumour DNA. The team has since expanded the research and has now profiled and successfully matched more than 700 tumour and blood samples from more cancer types.
Beyond the lab, next steps to further validate this approach include analysing data from large population health research studies already under way in several countries, where blood samples were collected months to years before cancer diagnosis. Then the approach will need to be ultimately validated in prospective studies for cancer screening.
The Latest on: Cancer blood test
via Google News
The Latest on: Cancer blood test
- ArcherDX and Illumina Partner for Future to Co-Market Portfolio of Planned In-Vitro Diagnostic (IVD) Testson January 10, 2020 at 7:16 am
ArcherDX, Inc. today announced a non-exclusive, multi-year partnership with Illumina, Inc. (NASDAQ: ILMN) intended to broaden access of next generation sequencing (NGS)-based oncology testing, ...
- Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in miceon January 10, 2020 at 4:03 am
Cancer stem cells (CSCs) may be responsible for treatment resistance ... APAP was used at 300 mg/kg and fed by gavage needle after mice were starved for 12 h. Blood was collected from mice by eye ...
- Study demonstrates accuracy of AI system in diagnosing prostate canceron January 10, 2020 at 4:00 am
Martin Eklund, Associate Professor at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet The AI system has been developed by the same team that launched the new ...
- Lung Cancer May Make The Skin Next To Your Nails To Appear Like Thison January 10, 2020 at 3:36 am
Lung cancer is a dreadful disease that kills millions of people worldwide. The World Health Organization revealed that lung cancer kills more patients compared to any other type of cancer. The health ...
- Justice Ruth Bader Ginsburg Announces She Is Cancer-Free: What to Knowon January 9, 2020 at 2:15 pm
This past summer, the 86-year-old U.S. Supreme Court Justice underwent intensive radiation for pancreatic cancer after doctors identified a malignant tumor during a routine blood test. “I’m ...
- Improving cancer screening programson January 9, 2020 at 12:25 pm
The most commonly used screening tests include the Pap smear for cervical cancer; fecal immunochemical test (FIT), fecal occult blood test (FOBT), colonoscopy, or sigmoidoscopy for colorectal cancer; ...
- Let's Talk About Canceron January 9, 2020 at 6:20 am
like a Pap smear (cervical cancer), mammogram (breast cancer), digital rectal examination and PSA blood test (prostate cancer), or colonoscopy (colon cancer). If your doctor feels this sign or symptom ...
- Biotechnological Breakthroughs Help Revamp the Fight Against Canceron January 9, 2020 at 5:21 am
/PRNewswire/ -- Biotechnology plays an important role throughout various sectors by improving industry standards, services, and developing new products.
- Natera Launches BESPOKE CRC Study to Evaluate Outcomes in 1,000 Signatera™ Patients with Stage II-III Colorectal Canceron January 9, 2020 at 5:05 am
/PRNewswire/ -- Natera, Inc. (NASDAQ: NTRA) a global leader in cell-free DNA testing, today announced a nationwide multi-center registry study called ...
via Bing News