In what is believed to be a world first, Griffith University researchers have cured cervical cancer in mice using CRISPR gene-editing technology.
“This is the first cure for any cancer using this technology,’’ said lead researcher Professor Nigel McMillan from Menzies Health Institute Queensland.
The scientists used CRISPR-Cas9 to successfully target and treat cervical cancer tumours in vivo (via injection into live and tumour-bearing mice) using “stealth” nanoparticles.
“The nanoparticles search out the cancer-causing gene in cancer cells and “edit it’’ by introducing some extra DNA that causes the gene to be misread and stop being made,’’ Professor McMillan said.
“This is like adding a few extra letters into a word, so the spell checker doesn’t recognise it “anyTTmore’’. Because the cancer must have this gene to produce, once edited the cancer dies.
“In our study, the treated mice have 100% survival and no tumours. The mice showed no other clinical signs such as inflammation from treatment but there may be other gene changes we haven’t measured yet.
“Other cancers can be treated once we know the right genes.”
Nearly all cervical cancers are caused by a human papillomavirus infection (HPV), with more than 250* women in Australia dying from the disease each year. *source: Cancer Australia
“Persistent infection with high-risk HPV is responsible for 99.7% of cervical cancer cases,’’ Professor McMillan said.
“After infection, the HPV integrates the E6 and E7 oncogene (genes with the potential to cause cancer), into the human genome which drive and sustain cervical cancer.”
The Griffith University scientists are working towards human trials of the gene therapy in the next five years.
The Latest on: Cervical cancer
via Google News
The Latest on: Cervical cancer
- Dozens of jobs to be lost in Yorkshire next month as cervical cancer screening labs closeon November 28, 2019 at 10:13 pm
Early results also show the vaccine for the human papillomavirus, which is given to all teenage girls in the UK, also means rates of cervical cancer are set to drop by 80 per cent over the coming ...
- 'We want Malawi to be free from cervical cancer'on November 27, 2019 at 9:04 pm
After being diagnosed with cervical cancer in 2012, Falesi Mwajomba took it upon herself to go door to door in a small village called Chikwawa in Malawi, encouraging women to go for cervical cancer ...
- Rwanda leads fight against cervical cancer in Africaon November 27, 2019 at 5:42 pm
Cervical cancer is the fourth most common cancer among women worldwide. But in Africa it is far deadlier than elsewhere, despite being a preventable disease. An ambitious health campaign in Rwanda has ...
- Go Doc Go brings first Human Papilloma Virus (HPV) testing units to Senegal and The Gambia to decrease cervical canceron November 27, 2019 at 7:00 am
Go Doc Go, a not-for-profit International medical organization, has been working in low-middle income countries since 2014 to prevent cervical cancer. Following World Health Organization (WHO) ...
- Sema4C mediates EMT inducing chemotherapeutic resistance of miR-31-3p in cervical cancer cellson November 27, 2019 at 2:41 am
The aim of this study was to explore the potential role of miR-31-3p/Sema4C in regulating EMT in cisplatin-resistant (CR) cervical cancer cells. High expression levels of Sema4C were more frequently ...
- Expert urges women to go for cervical cancer screening regularlyon November 27, 2019 at 12:55 am
Mrs. Helen Onwudiwe, the Head of Cervical Cancer Unit, Chukwuemeka Odumegwu Ojukwu Teaching Hospital, on Tuesday urged women of adult age to develop the habit of going for cervical cancer screening ...
- Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical canceron November 26, 2019 at 10:36 am
are widely used for the treatment of diverse types of cancer, whether EGFR-TKIs are effective against chemoresistant CSCs in cervical cancer is largely unknown. Here, we reveal that EGFR correlates ...
- Do Not Ignore Signs of Cervical Canceron November 26, 2019 at 9:45 am
On Healthy Living this week, a close look at cervical cancer, including its causes, symptoms and preventable measures one can take. We spoke to Dr. Kiyali Ouattara, Director of the international ...
- Cervical cancer campaigner Vicky Phelan reveals son learned about ‘how bad’ cancer diagnosis was while in schoolon November 23, 2019 at 11:30 pm
VICKY Phelan has revealed her young son found out how bad her cancer was after he was told in the schoolyard. The brave campaigner was thrust into the spotlight last year when she exposed the ...
- Massive Bio and The American Sexual Health Association Partner to Increase Patient Access to Cervical Cancer Clinical Trialson November 20, 2019 at 4:13 pm
Massive Bio, a leader in Artificial Intelligence (AI) based oncology clinical trial enrollment, and The American Sexual Health Association (ASHA), a leader in advancing the health of communities by ...
via Bing News