Coated pill carries microneedles that deliver insulin and other drugs to the lining of the small intestine.
Many drugs, especially those made of proteins, cannot be taken orally because they are broken down in the gastrointestinal tract before they can take effect. One example is insulin, which patients with diabetes have to inject daily or even more frequently.
In hopes of coming up with an alternative to those injections, MIT engineers, working with scientists from Novo Nordisk, have designed a new drug capsule that can carry insulin or other protein drugs and protect them from the harsh environment of the gastrointestinal tract. When the capsule reaches the small intestine, it breaks down to reveal dissolvable microneedles that attach to the intestinal wall and release drug for uptake into the bloodstream.
“We are really pleased with the latest results of the new oral delivery device our lab members have developed with our collaborators, and we look forward to hopefully seeing it help people with diabetes and others in the future,” says Robert Langer, the David H. Koch Institute Professor at MIT and a member of the Koch Institute for Integrative Cancer Research.
In tests in pigs, the researchers showed that this capsule could load a comparable amount of insulin to that of an injection, enabling fast uptake into the bloodstream after the microneedles were released.
Langer and Giovanni Traverso, an assistant professor in MIT’s Department of Mechanical Engineering and a gastroenterologist at Brigham and Women’s Hospital, are the senior authors of the study, which appears today in Nature Medicine. The lead authors of the paper are recent MIT PhD recipient Alex Abramson and former MIT postdoc Ester Caffarel-Salvador.
Langer and Traverso have previously developed several novel strategies for oral delivery of drugs that usually have to be injected. Those efforts include a pill coated with many tiny needles, as well as star-shaped structures that unfold and can remain in the stomach from days to weeks while releasing drugs.
“A lot of this work is motivated by the recognition that both patients and health care providers prefer the oral route of administration over the injectable one,” Traverso says.
Earlier this year, they developed a blueberry-sized capsule containing a small needle made of compressed insulin. Upon reaching the stomach, the needle injects the drug into the stomach lining. In the new study, the researchers set out to develop a capsule that could inject its contents into the wall of the small intestine.
Most drugs are absorbed through the small intestine, Traverso says, in part because of its extremely large surface area — 250 square meters, or about the size of a tennis court. Also, Traverso noted that pain receptors are lacking in this part of the body, potentially enabling pain-free micro-injections in the small intestine for delivery of drugs like insulin.
To allow their capsule to reach the small intestine and perform these micro-injections, the researchers coated it with a polymer that can survive the acidic environment of the stomach, which has a pH of 1.5 to 3.5. When the capsule reaches the small intestine, the higher pH (around 6) triggers it to break open, and three folded arms inside the capsule spring open.
Each arm contains patches of 1-millimeter-long microneedles that can carry insulin or other drugs. When the arms unfold open, the force of their release allows the tiny microneedles to just penetrate the topmost layer of the small intestine tissue. After insertion, the needles dissolve and release the drug.
“We performed numerous safety tests on animal and human tissue to ensure that the penetration event allowed for drug delivery without causing a full thickness perforation or any other serious adverse events,” Abramson says.
To reduce the risk of blockage in the intestine, the researchers designed the arms so that they would break apart after the microneedle patches are applied.
The new capsule represents an important step toward achieving oral delivery of protein drugs, which has been very difficult to do, says David Putnam, a professor of biomedical engineering and chemical and biomolecular engineering at Cornell University.
“It’s a compelling paper,” says Putnam, who was not involved in the study. “Delivering proteins is the holy grail of drug delivery. People have been trying to do it for decades.”
In tests in pigs, the researchers showed that the 30-millimeter-long capsules could deliver doses of insulin effectively and generate an immediate blood-glucose-lowering response. They also showed that no blockages formed in the intestine and the arms were excreted safely after applying the microneedle patches.
“We designed the arms such that they maintained sufficient strength to deliver the insulin microneedles to the small intestine wall, while still dissolving within several hours to prevent obstruction of the gastrointestinal tract,” Caffarel-Salvador says.
Although the researchers used insulin to demonstrate the new system, they believe it could also be used to deliver other protein drugs such as hormones, enzymes, or antibodies, as well as RNA-based drugs.
“We can deliver insulin, but we see applications for many other therapeutics and possibly vaccines,” Traverso says. “We’re working very closely with our collaborators to identify the next steps and applications where we can have the greatest impact.”
The Latest on: Dissolvable microneedles
via Google News
The Latest on: Dissolvable microneedles
- Dissolving Microneedles Improve Flu Vaccine Deliveryon November 2, 2019 at 5:00 pm
Conducted by researchers from Emory University and the Georgia Institute of Technology, the study is believed to be the first to evaluate the immunization benefits of dissolving microneedles. The ...
- Dissolvable Microneedles Could Replace Injected Vaccineson November 2, 2019 at 5:00 pm
Microneedles made from these materials also run the risk of breaking off in the skin, leaving tiny fragments behind. The new dissolvable patch eliminates this risk, as the microneedles are designed to ...
- Don’t Like Shots? Swallow This Pill Full of Microneedles Insteadon October 10, 2019 at 2:10 pm
According to the team’s study, which was published in the journal Nature Medicine on Monday, the pill consists of a 30-millimeter-long capsule housing a three-armed device covered in dissolvable ...
- Could a Pill Replace Insulin Shots?on October 9, 2019 at 7:16 am
When it gets to the small intestine, it breaks down into dissolving microneedles that attach to the intestinal wall and release the drug into the bloodstream. In tests in pigs, the capsule, loaded ...
- Pill with dissolvable needles could end diabetes jabson October 9, 2019 at 5:01 am
Insulin injections could become a thing of the past for people with diabetes if a pill that delivers dissolvable “microneedles” to the gut to administer drugs passes human trials. Several drugs ...
- New insulin pill could end daily injections for diabetes patientson October 9, 2019 at 3:42 am
A revolutionary insulin pill could prevent the millions of people living with type 1 diabetes from taking daily injections, researchers have said. Scientists from Massachusetts Institute of Technology ...
- Pill carrying microneedles could deliver insulin to diabetes patientson October 9, 2019 at 3:42 am
When the pill is ingested and reaches the small intestine, it breaks down into dissolving microneedles that attach to the intestinal wall, releasing the drug into the bloodstream. Previous attempts to ...
- Drug capsule could take sting out of insulin ingestionon October 8, 2019 at 1:31 am
Instead, when the new the capsule reaches the small intestine, it breaks down to reveal dissolvable microneedles that attach to the intestinal wall and release drug for uptake into the bloodstream.
- New Pill That Replaces Daily Injections Developedon October 7, 2019 at 6:15 pm
When the capsule reaches the small intestine, it breaks down to reveal dissolvable microneedles that attach to the intestinal wall and release drug for uptake into the bloodstream. "We are really ...
- New capsule can orally deliver drugs that usually have to be injectedon October 7, 2019 at 5:00 pm
When the capsule reaches the small intestine, it breaks down to reveal dissolvable microneedles that attach to the intestinal wall and release drug for uptake into the bloodstream. Many drugs, ...
via Bing News