This is like a painless Band-Aid for internal organs,” says Xuanhe Zhao, professor of mechanical engineering and of civil and environmental engineering at MIT. “You put the adhesive on, and if for any reason you want to take it off, you can do so on demand, without pain.”
Courtesy of the researchers
Removable adhesive could make it easier for surgeons to close up internal wounds.
Last year, MIT engineers developed a double-sided adhesive that could quickly and firmly stick to wet surfaces such as biological tissues. They showed that the tape could be used to seal up rips and tears in lungs and intestines within seconds, or to affix implants and other medical devices to the surfaces of organs such as the heart.
Now they have further developed their adhesive so that it can be detached from the underlying tissue without causing any damage. By applying a liquid solution, the new version can be peeled away like a slippery gel in case it needs to be adjusted during surgery, for example, or removed once the tissue has healed.
“This is like a painless Band-Aid for internal organs,” says Xuanhe Zhao, professor of mechanical engineering and of civil and environmental engineering at MIT. “You put the adhesive on, and if for any reason you want to take it off, you can do so on-demand, without pain.”
The team’s new design is detailed in a paper published today in the Proceedings of the National Academy of Sciences. Zhao’s co-authors are first authors Xiaoyu Chen and Hyunwoo Yuk along with Jingjing Wu at MIT, and Christoph Nabzdyk at Mayo Clinic Rochester.
In considering designs for their original adhesive, the researchers quickly realized that it is extremely difficult for tape to stick to wet surfaces, as the thin layer of water lubricates and prevents most adhesives from taking hold.
To get around a tissue’s natural slipperiness, the team designed their original adhesive out of biocompatible polymers including polyacrylic acid, a highly absorbent material commonly used in diapers and pharmaceuticals, that soaks up water, then quickly forms weak hydrogen bonds with the tissue’s surface. To reinforce these bonds, the researchers embedded the material with NHS esters, chemical groups that form stronger, longer-lasting bonds with proteins on a tissue’s surface.
While these chemical bonds gave the tape its ultrastrong grip, they were also difficult to break, and the team found that detaching the tape from tissue was a messy, potentially harmful task.
“Removing the tape could potentially create more of an inflammatory response in tissue, and prolong healing,” Yuk says. “It’s a real practical problem.”
Scotch tape for surgeons
To make the adhesive detachable, the team first tweaked the adhesive itself. To the original material, they added a new disulfide linker molecule, which can be placed between covalent bonds with a tissue’s surface proteins. The team chose to synthesize this particular molecule because its bonds, while strong, can be easily severed if exposed to a particular reducing agent.
The researchers then looked through the literature to identify a suitable reducing agent that was both biocompatible and able to sever the necessary bonds within the adhesive. They found that glutathione, an antioxidant naturally found in most cells, was able to break long-lasting covalent bonds such as disulfide, while sodium bicarbonate, also known as baking soda, could deactivate the adhesive’s shorter-lasting hydrogen bonds.
The team mixed concentrations of glutathione and sodium bicarbonate together in a saline solution, and sprayed the solution over samples of adhesive that they placed over various organ and tissue specimens, including pig heart, lung, and intestines. In all their tests, regardless of how long the adhesive had been applied to the tissue, the researchers found that, once they sprayed the triggering solution onto the tape, they were able to peel the tape away from the tissue within about five minutes, without causing tissue damage.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Super-strong surgical tape detaches on demandon June 24, 2020 at 5:47 am
Now they have further developed their adhesive so that it can be detached from the underlying tissue without causing any damage. By applying a liquid solution, the new version can be peeled away like ...
- MIT Engineers Develop Super-Strong Surgical Tape That Painlessly Detaches on Demandon June 24, 2020 at 3:17 am
Removable adhesive could make it easier for surgeons to close up internal wounds. Last year, MIT engineers developed a double-sided adhesive that could quickly and firmly stick to wet surfaces such as ...
- Easily Removable Surgical Tape to Seal Internal Woundson June 23, 2020 at 7:08 am
Researchers at MIT recently developed an adhesive tape that allows surgeons to seal internal wounds and that can readily stick to slippery internal surfaces, as a potential replacement for sutures.
- Researchers Submit Patent Application, “Label With Removable Component(S)”, for Approval (USPTO 20200175894)on June 22, 2020 at 5:54 pm
From Washington, D.C., NewsRx journalists report that a patent application by the inventors Francoeur, Roger; Livingston, Timothy Darren; Shinkle, II, Robert L.; Lamb, Shane; Vied, Matthew, filed on ...
- Best tubeless road tyres 2020 | Ditch your inner tubes with these tubeless optionson June 20, 2020 at 8:00 am
The rim also has to be sealed to keep air in. Some are airtight by design, with no spoke holes in the rim bed, others achieve this using an adhesive rim tape applied to the rim bed. To make sure ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
- Global Instant Adhesive Market 2020 Overview, Key Players, Segmentation Analysis, Development Status and Forecast by 2026on June 24, 2020 at 5:11 pm
MarketsandResearch.biz has released an exclusive report named Global Instant Adhesive Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2026 which comprehensively provides a ...
- Detachable Adhesive Is Like an Ouch-Free Band-Aid for Internal Organson June 24, 2020 at 2:55 pm
A double-sided adhesive developed by MIT engineers firmly sticks to biological tissues but can be adjusted during surgery or detached from a tissue or implant without causing any damage.
- Surface treatment for adhesive bonding: Thermoset vs. thermoplastic compositeson June 24, 2020 at 3:15 am
Source, all images | BTG Labs Surface treatment — involving some method of treating, abrading or cleaning a part or material surface — can be essential to achieving the necessary properties for ...
- Adhesive film turns smartwatch into biochemical health monitoring systemon June 23, 2020 at 1:05 pm
Engineers funded by the National Science Foundation and affiliated with UCLA have designed a thin adhesive film that could upgrade a consumer smartwatch into a health-monitoring system. The system ...
- MIT surgical adhesive detaches on demandon June 23, 2020 at 8:08 am
MIT created a surgical adhesive last year that was able to quickly and firmly stick to wet surfaces like biological tissues. The double-sided adhesive tape was shown to be usable to seal rips and ...