via University of Cambridge
Repurposing existing medicines focused on known drug targets is likely to offer a more rapid hope of tackling COVID-19 than developing and manufacturing a vaccine, argue an international team of scientists in the British Journal of Pharmacology.
“[Repurposed drugs] will have already been shown to be safe and so, if they can now be shown to be effective in COVID-19, they could be brought to clinical use relatively quickly”
Since the emergence of the SARS-CoV-2 virus in late 2019, more than 3.5 million people are known to have been infected, leading to over 240,000 deaths worldwide from COVID-19, the disease caused by the novel coronavirus. The race is on to find new drugs to treat COVID-19 patients and to develop a vaccine to prevent infection in the first place.
A team of researchers representing the International Union of Basic and Clinical Pharmacology today say there will be no ‘magic bullet’ to treat the disease and argue that a multi-pronged approach is needed to find new drugs. They caution that an effective and scalable vaccine is likely to take over a year before it can used to tackle the global pandemic.
When a virus enters our body, unless we have already developed immunity from previous infection or vaccination, it will break into our cells, hijacking their machinery and using it to replicate and spread throughout the body. Often, the symptoms we see are a result of our immune system fighting back in an attempt to clear the infection. In severe cases, this immune response can become overactive, potentially leading to a so-called cytokine storm, causing collateral damage to organs along the way.
“Any drug to treat COVID-19 will need to focus on the three key stages of infection: preventing the virus entering our cells in the first place, stopping it replicating if it gets inside the cells, and reducing the damage that occurs to our tissues, in this case, the lungs and heart,” said Professor Anthony Davenport from the University of Cambridge, one of the authors of the review.
The review looks at potential therapeutic drug targets – the chinks in the virus’s own armour or weak spots in the body’s defences. Two key targets appear to be proteins on the surface of our cells, to which SARS-CoV-2 binds allowing it entry – ACE2 and TMPRSS2. TMPRSS2 appears to be very common on cells, whereas ACE2 is usually present at low levels that increase depending on sex, age, and smoking history.
“As we know these two proteins play a role in this coronavirus infection, we can focus on repurposing drugs that already have regulatory approval or are in the late stages of clinical trials,” said Professor Davenport. “These treatments will have already been shown to be safe and so, if they can now be shown to be effective in COVID-19, they could be brought to clinical use relatively quickly.”
One promising candidate is remdesivir, a drug originally developed for Ebola. Although clinical trials found it to be insufficiently effective at treating Ebola, clinical trials in the USA have suggested the drug may be beneficial for treating patients hospitalised with COVID-19, and the FDA has now approved it for emergency use. There have also been promising findings from studies of monoclonal antibodies, but this type of drug is expensive to produce and therefore less likely to be scalable.
“While we’re waiting for a vaccine, drugs currently being used to treat other illnesses can be investigated as treatments for COVID-19 – in other words repurposed,” said Dr Steve Alexander from the University of Nottingham.
“There’s unlikely to be a single magic bullet – we will probably need several drugs in our armoury, some that will need be used in combination with others. The important thing is that these drugs are cheap to produce and easy to manufacture. That way, we can ensure access to affordable drugs across the globe, not just for wealthier nations.”
The team say that we need to move quickly to identify existing drugs that are effective in clinical trials so that we can begin treating patients as rapidly as possible, but also because cases are likely to fall during the summer meaning there will be fewer people who can be recruited to clinical trials ahead of an anticipated second wave of the disease in autumn. They estimate there are currently more than 300 clinical trials taking place worldwide, though many of these investigational drugs are unlikely to be effective for widespread use because either it is not clear which part of the disease pathway they are targeting or they cause unpleasant side-effects.
They also advise patience for the promise of developing an effective vaccine against the virus anytime soon. Even after a new vaccine candidate has been shown to offer immunity against the coronavirus in humans, it needs to be tested in larger numbers of people to ensure it is safe to use. Manufacturing and distributing a vaccine at the scale needed to tackle this pandemic will also present significant challenges.
“Although there are a lot of vaccines being developed around the world, which we hope will be successful, it’s still going to take a long time before those vaccines are shown to be effective and can be manufactured at the scale needed to make an impact,” said Dr Steve Alexander.
“Some of the vaccines may not work, so the more drugs that can be tested and the more we know about the targets, the more likely we are to get something which is effective. The very specificity of vaccines means they are limited in which viruses they can neutralise. The lessons we learn and the drugs we generate will hopefully provide a greater degree of protection, not just against the COVID-19 virus, but also against the next viral threat.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Trump, stewing over election loss, silent as COVID-19 surges across US at alarming paceon November 12, 2020 at 5:52 pm
Aides say Trump has shown little interest in the growing crisis even as new confirmed cases are skyrocketing and hospital intensive care units in parts of the country are nearing capacity.
- Federal Trade Commission Cracks Down On Unproven COVID-19 Treatmenton November 12, 2020 at 11:42 am
The Federal Trade Commission issued warning letters to several companies that marketed an unproven drug to treat COVID-19. Sales of the non-approved drug, thymosin alpha-1, were first reported by NPR.
- How coronavirus treatment has changedon November 11, 2020 at 1:44 pm
CNN's Sanjay Gupta breaks down how coronavirus treatment has changed for doctors in hospitals since the start of the pandemic.
- Covid-19 Live Updates: U.S. Hospitalizations Top 61,000, a Recordon November 11, 2020 at 11:42 am
Ben Carson, the housing and urban development secretary, has the virus. Cases in Thailand and Cambodia have been tied to a visit by Hungary’s foreign minister.
- Doctors critical of administration's Covid-19 antibody treatment rollouton November 11, 2020 at 10:18 am
Some doctors have serious reservations about the Trump administration's Covid-19 antibody treatment rollout.Doctors from Harvard Medical School shared their concerns in an editorial published ...
Go deeper with Google Headlines on:
COVID 19 treatment
Go deeper with Bing News on:
Repurposing existing drugs for Covid 19
- AstraZeneca's Calquence fails COVID-19 study, joining the list of repurposed meds that have fallen shorton November 12, 2020 at 5:12 am
Months after drugmakers launched an unprecedented COVID-19 research effort, some existing medicines have turned in promising results—but more of them have failed against the virus. And AstraZeneca’s ...
- Generics players join pledge to rapidly scale access to COVID-19 drugs. But will pharma sign on?on November 12, 2020 at 4:51 am
As dozens of drugmakers work to create new or repurposed therapies for COVID-19, developing nations worry they will be last in line for supply, behind their richer neighbors. Hoping to level the ...
- Novartis rare disease drug, repurposed for COVID-19, fails in late-stage studyon November 6, 2020 at 7:57 am
The Swiss drugmaker's COVID-19 research efforts now largely rest on the outcome of a recent alliance to develop oral medicines for the new coronavirus.
- Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19on October 27, 2020 at 5:01 pm
The global spread of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has paralyzed health systems and economies worldwide. As the quest for effective drugs ...
- We have bad news about one of the most promising new coronavirus drugson October 26, 2020 at 5:00 pm
Others repurposed existing drugs for COVID-19 — remdesivir, dexamethasone, and blood thinners are examples that have shown a degree of efficacy. And others are developing brand new drugs ...