New Pitt Research Uses Electrochemical Approach to Treat Infections of Metal-Based Implants
Titanium has many properties that make it a great choice for use in implants. Its low density, high stiffness, high biomechnanical strength-to-weight ratio, and corrosion resistance have led to its use in several types of implants, from dental to joints. However, a persistent problem plagues metal-based implants: the surface is also a perfect home for microbes to accumulate, causing chronic infections and inflammation in the surrounding tissue. Consequently, five to 10 percent of dental implants fail and must be removed within 10-15 years to prevent infection in the blood and other organs.
New research from the University of Pittsburgh’s Swanson School of Engineering introduces a revolutionary treatment for these infections. The group, led by Tagbo Niepa, PhD, is utilizing electrochemical therapy (ECT) to enhance the ability of antibiotics to eradicate the microbes.
“We live in a crisis with antibiotics: most of them are failing. Because of the drug- resistance that most microbes develop, antimicrobials stop working, especially with recurring infections,” says Dr. Niepa, author on the paper and assistant professor of chemical and petroleum engineering at the Swanson School, with secondary appointments in civil and environmental engineering and bioengineering. “With this technique, the current doesn’t discriminate as it damages the microbe cell membrane. It’s more likely that antibiotics will be more effective if the cells are simultaneously challenged by the permeabilizing effects of the currents. This would allow even drug-resistant cells to become susceptible to treatment and be eradicated.”
The novel method passes a weak electrical current through the metal-based implant, damaging the attached microbe’s cell membrane but not harming the surrounding healthy tissue. This damage increases permeability, making the microbe more susceptible to antibiotics. Since most antibiotics specifically work on cells that are going to replicate, they do not work on dormant microbes, which is how infections can recur. The ECT causes electrochemical stress in all the cells to sensitize them, making them more susceptible to antibiotics.
The researchers hope this technology will change how infections are treated. Researchers focused their research on Candida albicans (C. albicans), one of the most common and harmful fungal infections associated with dental implants. But while dental implants are one exciting application for this new technology, Niepa says it has other potential applications, such as in wound dressings.
Learn more: A “Shocking” New Way to Treat Infections
The Latest on: Electrochemical therapy
via Google News
The Latest on: Electrochemical therapy
- Turning up the heat on antibacterial-resistant diseaseson January 31, 2020 at 6:43 am
Photothermal therapy (PTT) is a proposed treatment for diseases like antibacterial-resistant ... was working on a method to make CPEs for organic electrochemical transistors (OECTs). They hypothesized ...
- Ultraflexible and transparent electroluminescent skin for real-time and super-resolution imaging of pressure distributionon January 31, 2020 at 2:17 am
Lee, H. et al. A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy. Nat. Nanotechnol. 11, 566–572 (2016).
- Medical Devices Offer a Boost to Viable and Cost-Effective Treatment Optionson January 30, 2020 at 5:00 am
NEW YORK, Jan. 30, 2020 /PRNewswire/ -- Medical devices can be used for a wide variety of applications, from surgical procedures to home health care, in a clinical setting or in the medical office.
- Endonovo Therapeutics Expands SofPulse® Sales to Plastic Surgery Centerson January 30, 2020 at 3:00 am
This non-invasive and non-pharmacologic therapy has no known side effects and presents no potential for overdose ... The Company's noninvasive, wearable Electroceuticals ® therapeutic devices work by ...
- Amplified Electrochemical Biosensing of Thrombin Activity by RAFT Polymerizationon January 29, 2020 at 4:36 pm
R. China School of Civil Engineering, Guangzhou University, Guangzhou 510006, P. R. China Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy ...
- Endonovo Therapeutics Announces First SofPulse® Sales to a Veterans Medical Centeron January 27, 2020 at 3:00 am
The therapy is non-invasive and non-pharmacologic ... wearable Electroceuticals ® therapeutic devices work by restoring key electrochemical processes that initiate anti-inflammatory and growth ...
- Continuous Glucose Monitoring Devices Market Size is Projected to Attain USD 1.25 Billion by 2026 | Reports and Dataon January 20, 2020 at 1:07 am
High incidence of diabetes, increasing geriatric population & continuous technological advancements across the globe are the key factors contributing to high CAGR of Continuous Glucose Monitoring ...
- Tivic Health Announces New Bioelectronic Sinus Pain Benefits At CES Eureka Park 50527on December 30, 2019 at 7:00 am
(PRNewsfoto/Tivic Health Systems Inc.) "The human body is an electrochemical system and ... company dedicated to developing microcurrent therapy solutions for chronic diseases and conditions.
- Imaging technique gives catalytic 2D material engineering a better viewon December 3, 2019 at 8:56 am
Scanning electrochemical cell microscopy (SECCM) allows imaging and quantitative analysis of hydrogen evolution reaction (HER) catalytically active sites in 1H MoS2 monolayers. (Image: Kanazawa ...
- Modified lactides promise new implementations in pharmacology and catalysison August 15, 2019 at 5:55 am
This approach was implemented in a family of electrochemical sensors ... photosensitizers in photodynamic therapy, and protein binding are also obvious. It is also important that the mentioned ...
via Bing News