New Pitt Research Uses Electrochemical Approach to Treat Infections of Metal-Based Implants
Titanium has many properties that make it a great choice for use in implants. Its low density, high stiffness, high biomechnanical strength-to-weight ratio, and corrosion resistance have led to its use in several types of implants, from dental to joints. However, a persistent problem plagues metal-based implants: the surface is also a perfect home for microbes to accumulate, causing chronic infections and inflammation in the surrounding tissue. Consequently, five to 10 percent of dental implants fail and must be removed within 10-15 years to prevent infection in the blood and other organs.
New research from the University of Pittsburgh’s Swanson School of Engineering introduces a revolutionary treatment for these infections. The group, led by Tagbo Niepa, PhD, is utilizing electrochemical therapy (ECT) to enhance the ability of antibiotics to eradicate the microbes.
“We live in a crisis with antibiotics: most of them are failing. Because of the drug- resistance that most microbes develop, antimicrobials stop working, especially with recurring infections,” says Dr. Niepa, author on the paper and assistant professor of chemical and petroleum engineering at the Swanson School, with secondary appointments in civil and environmental engineering and bioengineering. “With this technique, the current doesn’t discriminate as it damages the microbe cell membrane. It’s more likely that antibiotics will be more effective if the cells are simultaneously challenged by the permeabilizing effects of the currents. This would allow even drug-resistant cells to become susceptible to treatment and be eradicated.”
The novel method passes a weak electrical current through the metal-based implant, damaging the attached microbe’s cell membrane but not harming the surrounding healthy tissue. This damage increases permeability, making the microbe more susceptible to antibiotics. Since most antibiotics specifically work on cells that are going to replicate, they do not work on dormant microbes, which is how infections can recur. The ECT causes electrochemical stress in all the cells to sensitize them, making them more susceptible to antibiotics.
The researchers hope this technology will change how infections are treated. Researchers focused their research on Candida albicans (C. albicans), one of the most common and harmful fungal infections associated with dental implants. But while dental implants are one exciting application for this new technology, Niepa says it has other potential applications, such as in wound dressings.
Learn more: A “Shocking” New Way to Treat Infections
The Latest on: Electrochemical therapy
via Google News
The Latest on: Electrochemical therapy
- Continuous Glucose Monitoring Devices Market To Reach USD 1.42 Billion By 2027on March 18, 2020 at 6:46 am
Estimating and identifying appropriate blood glucose levels in patients through continuous glucose monitoring (CGM) devices is a vital component of therapy success. Continuous glucose monitoring ...
- Scuttlebiz: I spent an hour in sensory deprivation – and actually learned somethingon March 14, 2020 at 7:00 pm
That's right – I immersed myself in "float therapy" for the first time ... primary states of consciousness based on the brain’s electrochemical frequencies – beta, alpha, theta and delta.
- 3D microgroove electrical impedance sensing to examine 3D cell cultures for antineoplastic drug assessmenton March 8, 2020 at 4:08 pm
A new micro groove impedance sensor enables the real-time and high-throughput analysis of 3D lung cancer cell models. In-vitro cell-based assays are important for the screening of new cancer drugs.
- Novel Treatment Offers New Hope for Peripheral Neuropathyon March 2, 2020 at 8:37 am
NATIONAL HARBOR, Maryland ― Combined electrochemical treatment (CET ... who were taking medication for PPN before starting CET therapy, four stopped taking one or more of these medications.
- What Next? Tests for Coagulation Before Biopsieson February 27, 2020 at 9:00 pm
Advanced technologies such as fluorescent microscopy, microfluidics, electrochemical sensing ... flow in patients undergoing anticoagulant therapy in this self-testing technology.
- Medical Robotic Systems Market to Witness Stunning Growth with Accuray, Hansen Medical, Medrobotics, iRoboton February 21, 2020 at 3:47 am
It comprises of a computer-controlled electrochemical device that works ... Endoscopy Bot, Target Therapy Micro-robot, Disinfectant bots, AI Epidemiology, Others) The Global Medical Robotic ...
- Endonovo Therapeutics Begins Process For Medical Reimbursementson February 19, 2020 at 4:00 pm
We are actively pursuing medical reimbursement at this time to make the SofPulse ® therapy available and ... devices work by restoring key electrochemical processes that initiate anti ...
- Endonovo Therapeutics Announces collaborating with a Stanford University sponsored Orthopedic Shoulder and Knee Studyon February 13, 2020 at 4:39 am
Endonovo CMO, Dr. Nev Zubcevik DO, “The study will allow surgeons to determine if PEMF SofPulse ® therapy is beneficial ... devices work by restoring key electrochemical processes that ...
- Graphene Oxide Coated Gold Nanostars based Sensing Platform for Ultrasensitiveon December 10, 2019 at 11:41 am
SI. 3. The optimization of the rGO-AuNSs deposition protocol The surface modification techniqueof the electrochemically-cleanedGC electrode was optimized via drop-coat and electrochemical depositions ...
- Editors' Choiceon July 20, 2017 at 2:53 pm
designed and tested a nanoparticle-based therapy aimed at inducing certain immune cells ... trisaminocyclopropenium as the electrophotocatalyst in the presence of a mild electrochemical potential and ...
via Bing News