Scientists at the University of Surrey have discovered that a natural antioxidant commonly found in green tea can help eliminate antibiotic resistant bacteria.
The study, published in the Journal of Medical Microbiology, found that epigallocatechin (EGCG) can restore the activity of aztreonam, an antibiotic commonly used to treat infections caused by the bacterial pathogen Pseudomonas aeruginosa.
P. aeruginosa is associated with serious respiratory tract and bloodstream infections and in recent years has become resistant to many major classes of antibiotics. Currently a combination of antibiotics is used to fight P. aeruginosa. However, these infections are becoming increasingly difficult to treat, as resistance to last line antibiotics is being observed.
To assess the synergy of EGCG and aztreonam, researchers conducted in vitro tests to analyse how they interacted with the P. aeruginosa, individually and in combination. The Surrey team found that the combination of aztreonam and EGCG was significantly more effective at reducing P. aeruginosa numbers than either agent alone.
This synergistic activity was also confirmed in vivo using Galleria mellonella (Greater Wax Moth larvae), with survival rates being significantly higher in those treated with the combination than those treated with EGCG or aztreonam alone. Furthermore, minimal to no toxicity was observed in human skin cells and in Galleria mellonella larvae.
Researchers believe that in P. aeruginosa, EGCG may facilitate increased uptake of aztreonam by increasing permeability in the bacteria. Another potential mechanism is EGCG’s interference with a biochemical pathway linked to antibiotic susceptibility.
Lead author Dr Jonathan Betts, Senior Research Fellow in the School of Veterinary Medicine at the University of Surrey, said: “Antimicrobial resistance (AMR) is a serious threat to global public health. Without effective antibiotics, the success of medical treatments will be compromised. We urgently need to develop novel antibiotics in the fight against AMR. Natural products such as EGCG, used in combination with currently licenced antibiotics, may be a way of improving their effectiveness and clinically useful lifespan.”
Professor Roberto La Ragione, Head of the Department of Pathology and Infectious Diseases in the School of Veterinary Medicine at the University of Surrey, said: “The World Health Organisation has listed antibiotic resistant Pseudomonas aeruginosa as a critical threat to human health. We have shown that we can successfully eliminate such threats with the use of natural products, in combination with antibiotics already in use. Further development of these alternatives to antibiotics may allow them to be used in clinical settings in the future.”
The Latest on: Antibiotic resistant bacteria
via Google News
The Latest on: Antibiotic resistant bacteria
- Drug-Resistant Bacteria Can Be Hidden Danger for People with COVID-19on June 23, 2020 at 3:08 pm
Nearly half of patients who’ve died from COVID-19 had a secondary bacterial infection. Sometimes, these secondary infections are resistant to antibiotics and antifungals, making them difficult and ...
- Study: Increased use of human antibiotics on rice crops may fuel antibiotic resistanceon June 23, 2020 at 7:15 am
Farmers in parts of Asia are spraying antibiotics deemed "critical" for human medicine on rice crops, raising fears they may be fuelling antibiotic resistance, say researchers.
- Antibiotic use on crops isn't being monitoried in most countrieson June 23, 2020 at 6:42 am
Though antibiotics have been used for decades to combat bacterial diseases among various crop varieties, including apples and pears, the practice isn't closely monitored. New research -- published ...
- Bacteria are always at war. Understanding their use of weapons may lead to antibiotic alternativeson June 23, 2020 at 3:25 am
A small glimmer of light passes from one bacterium to another. Under the microscope it might not look like much, but there's a deadly battle underway: the second cell has just been hit by a poisoned ...
- UQ superbug drug discoveries will be fast-tracked under international research dealon June 22, 2020 at 6:32 pm
Antibiotics discovered at The University of Queensland will be fast-tracked under an US$11 million international research deal.
- Global deal follows UQ superbug drug discoverieson June 22, 2020 at 10:03 am
X funding will enable UQ researchers to develop Octapeptin-X (OPX) as a safe treatment for drug-resistant infections deemed untreatable by conventional therapies.
- Click... Resistant bacteria caught in the acton June 22, 2020 at 10:03 am
As humanity fights against the coronavirus, the battle against antibiotic-resistant bacteria continues. Scientists at UCLouvain have succeeded in capturing unique images of protein soldiers that help ...
- Click...Resistant Bacteria Caught in the Act! (image)on June 22, 2020 at 8:05 am
As humanity fights against the coronavirus, the battle against antibiotic resistant bacteria continues Scientists at UCLouvain have succeeded in capturing unique images of protein soldiers that help ...
- Coronavirus doctors’ overuse of antibiotics could spur resistance and raise death tollon June 20, 2020 at 5:13 pm
Doctors knew antibiotics weren’t effective against the coronavirus, but they feared patients could develop life-threatening bacterial co-infections and used them anyway, raising concerns about ...
- Emerging threat to coronavirus patients: ‘Superinfections’ with drug-resistant bacteriaon June 18, 2020 at 3:28 am
It isn’t always the coronavirus — or any virus — that kills patients with COVID-19. Bacteria can, too. While bacterial and viral infections manifest as similar symptoms, they are treated very ...
via Bing News