Researchers at the University of Houston have found neuro biomarkers for Parkinson’s disease that can help create the next generation of “smart” deep brain stimulators, able to respond to specific needs of Parkinson’s disease patients.
Those with the disease often undergo the high-frequency brain stimulation, a well-established therapy for the progressive nervous system disorder that affects movement, but the therapy has been imprecise.
Currently, stimulators can only be programmed clinically and are not adaptable to the fluctuating symptoms of the disease which can include tremors, slowness or inability to walk. The biomarkers are key to improving the technology to make it responsive, or smart.
“We can now make the closed-loop stimulator adaptive to sense a patient’s symptoms, so it can make the adjustments to the fluctuations in real time, and the patient no longer has to wait for weeks or months until the doctor can adjust the device,” said Nuri Ince, associate professor of biomedical engineering. He and doctoral student Musa Ozturk, lead author of the paper, published their findings in Movement Disorders journal.
Nearly 10 million people worldwide are living with Parkinson’s disease and approximately 60,000 Americans are diagnosed with the disease each year.
The team also reports a new understanding of the electrophysiology of Parkinson’s disease after examining cross frequency coupling in the subthalamic nucleus of patients with Parkinson’s disease both in the OFF state (before medication) and the ON state (after medication). Coupling, the interaction between the brain waves, has been reported in the past, but its significance and functional role have not been well understood.
The team reports that in the OFF state, the amplitude of high-frequency brain wave oscillations in the 200-300Hz range was coupled with the phase of low-beta (13-22Hz) in all patients. After transition to the ON state, three distinct coupling patterns were observed among subjects. Among these, patients showing ON coupling between high-beta (22-30Hz) and high-frequency oscillations in the 300-400Hz range had significantly greater improvement in bradykinesia, or slowness of movement, one of the cardinal manifestations of Parkinson’s disease.
“Previous research showed coupling only existed in the basal ganglia of untreated patients and assumed to block the brain from functioning properly,” said Ozturk. “We found that strong coupling also exists in treated patients, though at different frequencies, so in effect we have ‘cleared coupling’s name’ and showed the frequencies involved in coupling impacts whether its effects are negative or positive.”
The Latest on: Smart brain simulators
via Google News
The Latest on: Smart brain simulators
- Vote for the Engineer of the Yearon August 4, 2020 at 5:00 pm
Her recent activities include the application of electromagnetic, transient, and channel simulators to solve the challenges of ... and has recently released a new book, The Left Brain Speaks, the ...
- A trio of faculty members explore how VR can help combat neurological diseaseson August 4, 2020 at 12:07 am
He turned the USC School of Cinematic Arts to help him design the computer simulation ... to understand the human brain and to improve the human condition.” The USC SMART-VR Center is funded ...
- Man's illegal online e-cigarette business derailed by HSA, fined S$45,000on August 2, 2020 at 8:34 pm
Sim obtained his stocks from an unidentified man known only as "Vince", whom he got to know on Carousell. He advertised these tablets as "smart pills" or "brain boosters" and sold three strips of ...
- Artificial General Intelligence will not resemble human intelligenceon July 30, 2020 at 3:45 am
Airplanes don't flap their wings like birds, and artificial general intelligence (AGI) will never think like the human brain, which is more complex than we imagine ...
- Microsoft Flight Simulator's physical edition will include 10 discson July 25, 2020 at 4:52 pm
it is an ideal way of entering the new age of flight simulation," Mathijs Kok, a forum administrator for Microsoft's retail partner Aerosoft, wrote in a forum post. Entertain your brain with the ...
- Cloud-based software to create your own lightingon July 24, 2020 at 6:16 am
Javier Iglesias adds that, "not following a good sunlight diet affects our routine and our state of mind, as our brain uses lighting information ... Kumux has just launched the 2.0 version of its ...
- How to reach the right state of mind before a mission to Mars, according to an astrophysiciston July 18, 2020 at 10:05 am
Sure, a growing body of research now documents the impact of microgravity on one’s brain and body ... the Hawai’i Space Exploration Analog and Simulation (HI-SEAS) involve sequestering ...
- Elon Musk says his brain chip Neuralink company could 're-train' area associated with depression and addictionon July 16, 2020 at 9:29 am
Musk explained that the device is about one inch in diameter, similar to the face of a smart watch ... and things for epileptic seizures, deep brain simulation, artificial hips and knees that ...
- WIMI Hologram AR Develops Its Own 5G Holographic Chip to Connect With Mobile Giants and Restore 98% of the Digital Simulation Effecton July 8, 2020 at 1:05 am
It's the brain that drives smart products; It is the basis for the ... camera or digital light field signal generated by the light simulation by computer graphics technology.
- The best sunrise alarm clock for 2020on May 2, 2020 at 11:31 am
According to a small study in the journal Behavioral Brain Research ... One is the sunrise simulation clock that I use every day, and others are recommended by experts and reviewers on Amazon.
via Bing News