A drug with three active ingredients that are released in sequence at specific times: Thanks to the work of a team at the Technical University of Munich (TUM), what was once a pharmacologist’s dream is now much closer to reality. With a combination of hydrogels and artificial DNA, nanoparticles can be released in sequence under conditions similar to those in the human body.
It is becoming much more common for patients to be treated with several different medications. It is often necessary for the patient to take them at fixed intervals – a limitation that makes everyday life difficult and increases the risk of doses being skipped or forgotten.
Oliver Lieleg, Professor of Biomechanics and a member of the Munich School of BioEngineering at TUM, and doctoral candidate Ceren Kimna have now developed a process that could serve as the basis for medications containing several active ingredients that would reliably release them in the body in a pre-defined sequence at specified times. “For example, an ointment applied to a surgical incision could release pain medication first, followed by an anti-inflammatory drug and then a drug to reduce swelling,” explains Oliver Lieleg.
One active ingredient after the other
“Ointments or creams releasing their active ingredients with a time delay are not new in themselves,” says Oliver Lieleg. With the drugs currently in use, however, there is no guarantee that two or more active ingredients will not be released into the organism simultaneously.
To test the principle behind their idea, Oliver Lieleg and Ceren Kimna used nanometer-sized silver, iron oxide and gold particles embedded in a special gel-like substance known as a hydrogel. They then used a spectroscopic method to track the exit of the particles from the gel. The particles selected by the researchers have similar motion characteristics within the gel to the particles used to transport real active ingredients, but are easier and cheaper to make.
The special ingredient controlling the nanoparticles is artificial DNA. In nature, DNA is above all the carrier of genetic information. However, researchers are increasingly exploiting another property: The ability of DNA fragments to be combined with great accuracy, both in terms of the types of bonds and their strength, for example to build machines on a nanometer scale.
The DNA cascade: compress and then release at the right instant
The silver particles were released first. In the initial state, the particles were bound together by DNA fragments designed by Lieleg and Kimna using special software. The resulting particle clusters are so large that they are unable to move in the hydrogel. However, when a saline solution is added, they separate from the DNA. They can now move in the gel and drift to the surface. “Because the saline solution has approximately the same salinity as the human body, we were able to simulate conditions where the active ingredients would not be released until the medication is applied,” explains Ceren Kimna.
The mesh-like DNA structure surrounding the iron oxide particles consists of two types of DNA: The first has one end attached to the iron oxide particles. The second type is attached to the loose ends of the first type. These structures are not affected by the saline solution. The iron oxide particles can only be released when the first clusters have dissolved. This event releases not only the silver nanoparticles, but also DNA, which eliminates the “connection DNA” of the second cluster without forming connections itself. As a result, the iron oxide particles can separate. This releases DNA fragments which in turn act as the key to the third DNA-nanoparticle combination.
“The consistency of ointments makes them the most obvious solution for a hydrogel-based approach. However, this principle also has the potential to be used in tablets that could release several effective ingredients in the body in a specific order,” explains Prof. Lieleg.
Learn more: One at a time
The Latest on: Drug delivery
via Google News
The Latest on: Drug delivery
- Needle-free Drug Delivery Devices Market Forecast 2020-2024 - Covid-19 Impact and Global Analysis – by Product and by Geography | Technavioon November 30, 2020 at 6:59 am
Worried about the impact of COVID-19 on your Business? Here is an Exclusive report talking about Market scenarios, Estimates, the impact of lockdown, and Customer Behaviour. The report on the ...
- Researcher uses fruit for less toxic drug deliveryon November 30, 2020 at 12:37 am
University of Louisville researchers have found a less toxic way to deliver medicines by using the natural lipids in plants, particularly grapefruit and ginger.
- UofL researcher uses fruit for less toxic drug deliveryon November 29, 2020 at 9:17 pm
UofL researchers have found a less toxic way to deliver medicines by using the natural lipids in plants, particularly grapefruit and ginger. The resulting intellectual property portfolio consisting of ...
- Diabetes Drug Delivery Devices Market, 2030 - ResearchAndMarkets.comon November 27, 2020 at 6:02 am
The “Diabetes Drug Delivery Devices Market, 2020-2030” report has been added to ResearchAndMarkets.com’s offering. The “Diabetes Drug Delivery Devices Market, 2020-2030” report features an extensive ...
- Global Liposome Drug Delivery (Liposomes Drug Delivery) Market 2024: Size, Key Companies, Trends, Growth and Regional Forecasts Researchon November 26, 2020 at 4:50 pm
The report outlines the competitive framework of the “Liposome Drug Delivery (Liposomes Drug Delivery) Market” ...
- Powering Advances in Drug Delivery With Sound Waveson November 25, 2020 at 4:19 am
Researchers have revealed how high-frequency sound waves can be used to build new materials, make smart nanoparticles and even deliver drugs to the lungs for painless, needle-free vaccinations. While ...
- Sound waves power new advances in drug delivery and smart materialson November 24, 2020 at 8:13 am
Researchers have revealed how high-frequency sound waves can be used to build new materials, make smart nanoparticles and even deliver drugs to the lungs for painless, needle-free vaccinations.
- Halozyme: A "Better Mousetrap" in Drug Deliveryon November 24, 2020 at 2:15 am
We’re really intrigued by is Halozyme (HALO), which has a better mousetrap when it comes to drug delivery, asserts Mike Cintolo...
- Global Diabetes Drug Delivery Devices Market Report 2020-2030: Current Market Landscape and Likely Adoption of Diabetes Drug Delivery Deviceson November 23, 2020 at 11:51 pm
The "Diabetes Drug Delivery Devices Market, 2020-2030" report has been added to ResearchAndMarkets.com's offering. The "Diabetes Drug Delivery Devices Market, 2020-2030" report features an extensive ...
- Microneedle-based Drug Delivery System Market 2020 Research, Key Players, Industry Overview, Supply and Consumption Analysis 2026on November 23, 2020 at 6:46 pm
Nov 24, 2020 (The Expresswire) -- Global “Microneedle-based Drug Delivery System Market” forecast 2020-2026 gives a dynamic review of the market ...
via Bing News