What should personalized, precision treatment of cancer look like in the future?
We know that people are different, their tumors are different, and they respond differently to different therapies. Medical teams of the future might be able to create a ?“virtual twin” of a person and their tumor. Then, by tapping supercomputers, physician-led teams could simulate how tumor cells behave to test millions (or billions) of possible treatment combinations. Ultimately, the best combinations might offer clues towards a personalized, effective treatment plan.
Sound like wishful thinking? The first steps towards this vision have been undertaken by a multi-institution research collaboration that includes Jonathan Ozik and Nicholson Collier, computational scientists at the U.S. Department of Energy’s Argonne National Laboratory.
The research team, which includes collaborators at Indiana University and the University of Vermont Medical Center, brought the power of high-performance computing to the thorny challenge of improving cancer immunotherapy. The team tapped twin supercomputers at Argonne and the University of Chicago, finding that high-performance computing can yield clues in fighting cancer, as discussed in a June 7 article published in Molecular Systems Design and Engineering.
“With this new approach, researchers can use agent-based modeling in more scientifically robust ways.” — Nicholson Collier, computational scientist at Argonne and the University of Chicago
Standing up to cancer
Cancer immunotherapy is a promising treatment that realigns your immune system to reduce or eliminate cancer cells. The therapy, however, helps only 10 to 20 percent of patients — partly because the way in which cancer cells and immune cells mingle is complex and poorly understood. Proven rules are scarce.
To begin uncovering the rules of immunotherapy, the team turned to a set of three tools:
- Agent-based modeling, which predicted the behavior of individual ?“agents” – cancer and immune cells, in this case
- Argonne’s award-winning workflow technology to take full advantage of the supercomputers
- A guiding framework to explore models and dynamically direct and track results
The trio operate in a hierarchy. The framework, developed by Ozik, Collier, Argonne colleagues, and Gary An, a surgeon and professor at the University of Vermont Medical Center, is called Extreme-scale Model Exploration with Swift (EMEWS). It oversees the agent-based model and the workflow system, the Swift/T parallel scripting language, developed at Argonne and the University of Chicago.
What is unique about this combination of tools? ?“We are helping more people in a variety of computational science fields to do large-scale experimentation with their models,” said Ozik, who — like Collier — holds a joint appointment at the University of Chicago. ?“Building a model is fun. But without supercomputers, it is difficult to really understand the full potential of how models can behave.”
The Latest on: Personalized medicine
via Google News
The Latest on: Personalized medicine
- Doctors Save Young Ballerina’s Life, Career With Personalized Cancer Treatmenton August 12, 2019 at 2:40 pm
Personalized medicine, however, takes the approach that there may be other ways to get to the goal line that takes the patient’s other needs into account. That’s what saved Valle’s leg and career.
- Recruiting The Dalai Lama To Bring Compassion Back Into Medicineon August 9, 2019 at 12:32 pm
Ralph Snyderman is known as “The Father of Personalized Medicine.” He used to oversee the selection of medical students at Duke University in his role as chancellor for health affairs at Duke ...
- DNA, fruit flies and the quest to treat cancer with precision medicineon August 6, 2019 at 5:48 am
Instead, cancer researchers are focused on finding ways to treat individual strains of the disease through personalized or precision medicine. “Cancer therapy is becoming customized to each ...
- Pharmazam Launches Personalized Real-Time Medication Management and Healthcare Systemon August 6, 2019 at 5:34 am
Pharmazam, LLC is a Tampa, Florida-based biotech licensed healthcare technology firm delivering personalized medicine and healthcare management solutions through integrated technologies and ...
- Understanding the Difference Between Precision Medicine and Personalized Care for Lung Canceron August 5, 2019 at 11:25 am
Ravi Salgia, MD, professor and chair, Department of Medical Oncology & Therapeutics Research, associate director for clinical sciences, City of Hope, Durante, California, says there is a difference ...
- Personalized Medicine Market Size to Garner more than US$ 1.7 Trillion by 2026on August 1, 2019 at 5:01 am
Aug 01, 2019 (Global QYResearch via COMTEX) -- The Global Personalized Medicine Market size projected to register US$ 4 billion by 2026 and market growing at noteworthy CAGR around 1 % from 2019 to ...
- Global Clinical Trials Market Projected to Exceed $65 Billion by 2025 - Shift Towards Personalized Medicine Drives Market Growth - ResearchAndMarkets.on August 1, 2019 at 4:00 am
DUBLIN--(BUSINESS WIRE)--The "Clinical Trials Market Analysis by Phase (Phase I/II/III/IV), by Study Design (Interventional, Observational, Expanded Access), by Indication (Autoimmune, Pain management ...
- Personalized Medicine Research Report 2019: Focus on Scientific & Commercial Aspects to 2028 - ResearchAndMarkets.comon July 31, 2019 at 2:29 am
DUBLIN--(BUSINESS WIRE)--The "Personalized Medicine - Scientific & Commercial Aspects" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering. Profiles of 338 companies ...
- Scientific & Commercial Analysis of the Global Personalized Medicine Market, 2028 with Profiles of 350+ Companies with 616 Collaborationson July 30, 2019 at 5:00 pm
DUBLIN, July 31, 2019 /PRNewswire/ -- The "Personalized Medicine - Scientific & Commercial Aspects" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering. Profiles of 338 ...
- Personalized Wellness Past and Futureon July 26, 2019 at 2:11 am
The future of personalized medicine looks even more promising with the advent of the burgeoning field of precision medicine. The National Academy of Sciences, Engineering, and Medicine defines ...
via Bing News