Gut diseases such as inflammatory bowel disease (IBD) are increasingly prevalent worldwide, especially in industrialised countries. In 2015 alone, 250,000 people in the UK were diagnosed with IBD, and 3 million in the United States (1, 2). Symptoms can include pain and swelling of the stomach, bloody diarrhoea, weight loss and extreme tiredness.
A new study in Experimental Physiology proposes a novel, non-invasive test for assessing gut function that may help screen and monitor treatment of gut diseases using only a small sample (1 mL) of blood and stool. How well your gut functions is determined by the gut-blood barrier , a complex multi-layer system. This can be compared to a fine-tuned filter that precisely controls the passage of nutrients and prevents bacteria passing from inside the bowel into the bloodstream.
In those with IBD, and other intestinal diseases, the gut-blood barrier is impaired. Here the intestinal wall is more like a ripped sieve, allowing more bacterial products to pass from the gut into the blood. This is commonly referred to as a leaky gut.
This test measures the concentration of gut bacterial products (produced by bacteria during metabolism) in the patient’s blood and stool. The authors believe that with further research this assessment of gut leakage will be very important in the diagnosis and treatment of IBD and other intestinal diseases.
The usual strategy for diagnosing and monitoring IBD is based on a colonoscopy, which is invasive, often requires anaesthesia, and assesses structural lesions, rather than gut malfunction. Gut disorders can happen before there are visible structural changes, so diagnosing based on functional tests evaluating gut leakage could allow clinicians to detect the disease earlier. While there is no cure for IBD, it is controllable. Early diagnosis would enable patients to control symptoms before they became severe, improving their quality of life.
This new research provides a non-invasive, simple test that could not only be useful for diagnosing IBD, but also other gut disorders, such as celiac disease and food allergies. It’s also helpful for detecting diseases that result in a leaky gut, such as heart failure, high blood pressure and liver ailments.
Marcin Ufnal, senior author on the study said:
“This may be a very important tool for diagnosis and treatment of gut and other diseases, using the leaky gut as a marker for disease, as well as a potential target for treatment. “
Learn more: New, non-invasive test for bowel diseases
The Latest on: Gut diseases
via Google News
The Latest on: Gut diseases
- Study reveals connection between gut bacteria and vitamin D levelson November 30, 2020 at 10:06 am
UC San Diego researchers discovered that the makeup of a person's gut microbiome is linked to their levels of active vitamin D, and revealed a new understanding of vitamin D and how it's typically ...
- Glyphosate Exposure Could Disrupt Human Gut Microbiomeon November 25, 2020 at 5:30 pm
Exposure to glyphosate, the main ingredient in the weedkiller Roundup, could adversely affect the microbes in our gut, which could lead to poor health. Glyphosate is a controversial broad action ...
- Specific bacterium in the gut linked to irritable bowel syndromeon November 25, 2020 at 1:23 pm
Researchers at the University of Gothenburg have detected a connection between Brachyspira, a genus of bacteria in the intestines, and IBS—especially the form that causes diarrhea. Although the ...
- Specific bacterium in the gut associated with IBS symptomson November 25, 2020 at 1:07 pm
Researchers at the University of Gothenburg have detected a connection between Brachyspira, a genus of bacteria in the intestines, and IBS -- especially the form that causes diarrhea.
- Gut hormones' regulation of fat production abnormal in obesity, fatty liver diseaseon November 25, 2020 at 12:35 pm
Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, ...
- Researchers link specific gut bacteria to irritable bowel syndromeon November 25, 2020 at 11:54 am
Researchers announced a connection on Wednesday between Brachyspira, a specific intestinal bacterium, and the incidence of irritable bowel syndrome.
- Specific bacterium in the gut linked to irritable bowel syndrome (IBS)on November 25, 2020 at 11:49 am
Researchers have detected a connection between Brachyspira, a genus of bacteria in the intestines, and IBS -- especially the form that causes diarrhea. Although the discovery needs confirmation in ...
- Breakthrough in studying the enzyme that ultimately produces fish odour syndromeon November 23, 2020 at 8:03 am
Fish odour syndrome (trimethylaminuria) is a debilitating disease, in which the liver cannot break down the smelly chemical trimethylamine which is produced by enzymes from bacteria residing in the ...
- New evidence of gut-brain mechanism involved in MS flare-upson November 22, 2020 at 6:58 pm
New research, led by a team from UC San Francisco, has shown how immune cells produced in the gut play a protective role during multiple sclerosis (MS) flare-ups. For the first time, scientists have ...
- Lung disease associated with gut microbiome alterationson November 20, 2020 at 6:12 am
A new Australian study, published in the journal Nature Communications, is the first research to investigate the relationship between chronic obstructive pulmonary disease (COPD) and the gut ...
via Bing News