A new compound developed by University of Sheffield experts has killed antibiotic-resistant gram-negative bacteria, including E. coli, during tests
- New treatments for gram-negative bacteria are vital as they are rapidly becoming immune to current drugs
- Antimicrobial resistance is already responsible for 25,000 deaths in the EU each year
- The research could pave the way for new treatment of life-threatening superbugs
A new compound which visualises and kills antibiotic-resistant superbugs has been discovered by scientists at the University of Sheffield and the Science and Technology Facilities Council (STFC).
The team, led by Professor Jim Thomas, from the University of Sheffield’s Department of Chemistry, is testing new compounds developed by his PhD student Kirsty Smitten on antibiotic resistant gram-negative bacteria, including pathogenic E. coli.
Gram-negative bacteria strains can cause infections including pneumonia, urinary tract infections and bloodstream infections. They are difficult to treat as the cell wall of the bacteria prevents drugs from getting into the microbe.
Antimicrobial resistance is already responsible for 25,000 deaths in the EU each year, and unless this rapidly emerging threat is addressed, it’s estimated by 2050 more than 10 million people could die every year due to antibiotic resistant infections.
Doctors have not had a new treatment for gram-negative bacteria in the last 50 years, and no potential drugs have entered clinical trials since 2010.
The new drug compound has a range of exciting opportunities. As Professor Jim Thomas explains: “As the compound is luminescent it glows when exposed to light. This means the uptake and effect on bacteria can be followed by the advanced microscope techniques available at STFC’s Central Laser Facility (CLF).
“This breakthrough could lead to vital new treatments to life-threatening superbugs and the growing risk posed by antimicrobial resistance.”
The studies at Sheffield and CLF have shown the compound seems to have several modes of action, making it more difficult for resistance to emerge in the bacteria. The next step of the research will be to test it against other multi-resistant bacteria.
In a recent report on antimicrobial resistant pathogens, the World Health Organisation put several gram-negative bacteria at the top of its list, stating that new treatments for these bacteria were ‘Priority 1 Critical’ because they cause infections with high death rates, are rapidly becoming resistant to all present treatments and are often picked up in hospitals.
The Latest on: Antibiotic-resistant superbugs
No news articles
via Google News
The Latest on: Antibiotic-resistant superbugs
- Melbourne scientists’ accidental discovery stops superbug that kills 30 Australians a weekon August 16, 2019 at 12:18 am
As other antibiotic-resistant superbugs also rely on spore production to spread, the team are hoping the discovery could stop other infections. Because cephamycin antibiotics are already proven safe, ...
- Scientists find a potent weapon against antibiotic resistanceon August 15, 2019 at 7:44 am
In 2013, the Centers for Disease Control and Prevention reported that at least 2 million people get an antibiotic-resistant infection each year in the United States. Of these, 23,000 people die. One ...
- Antibiotic-resistant superbugs pose ‘existential risk’ to Irish health serviceon August 13, 2019 at 7:06 pm
Antibiotic-resistant superbugs pose an “existential risk” to the Irish health service that could become an irreversible problem, Health Service Executive (HSE) director general Paul Reid has warned.
- Researchers Search for Ideas to Fight Antibiotic Resistanceon August 13, 2019 at 7:32 am
By knowing how these superbugs acquire resistance ... In 2014, the World Health Organization reported that antibiotic-resistant infections were on pace to kill 10 million people per year worldwide by ...
- Better than bees in your eyeon August 8, 2019 at 9:56 am
So yes, it’s certainly not good that flying insects are possibly carrying deadly, antibiotic-resistant superbugs throughout your facility, and you should definitely ask them to go back outside and ...
- 5 easy ways to protect your patients from superbugson August 7, 2019 at 1:06 pm
Antibiotic-resistant infections create massive challenges ... antibiotic that can potentially increase a patient's risk of superbug infection — in or out of the hospital. A study earlier this ...
- Why Are These Medical Instruments So Tough to Sterilize?on August 7, 2019 at 11:32 am
An outbreak of antibiotic-resistant bacteria at the hospital in 2015 was traced ... The rising prevalence of superbugs — life-threatening germs that are resistant to powerful antibiotics — has ...
- Genetically Modified Viruses Help Save A Patient With A ‘Superbug’ Infectionon August 6, 2019 at 8:14 pm
hinting at new ways to fight antibiotic-resistant bacteria.
- An ambitious plan to stop the rise of superbugson August 5, 2019 at 4:28 am
Amplifying the problem is that some hospitals don't routinely screen patients for antibiotic resistant microbes. There are patients who carry ARB in their microbiomes and it's pretty difficult to ...
- Antibiotic-resistant superbugs on the rise and leaving patients with life-long illnesson August 4, 2019 at 12:58 pm
Anthony Fox was a young father of two with a career in the public service ahead of him when a stroke knocked him down. Father-of-two Anthony Fox struggled to recover from a stroke after contracting a ...
via Bing News