The action of a gene called ATDC is required for the development of pancreatic cancer, a new study finds.
The work builds on the theory that many cancers arise when adult cells—to resupply cells lost to injury and inflammation—switch back into more “primitive,” high-growth cell types, like those that drive fetal development.
When this reversion happens in the presence of other genetic mistakes, a repair process meant to start and stop quickly continues unchecked.
New details of this cancer-causing switch to primitive cells, and of the role of ATDC in pancreatic cancer formation, are revealed in a study of mice and human patient samples published online May 2 in the journal Genes & Development.
Led by researchers from NYU School of Medicine and the University of Michigan—Ann Arbor, the study found that ATDC must be active if pancreatic cells, when injured, are to reacquire primitive stem-cell qualities and undergo the early steps that lead to the development of pancreatic cancer.
“We found that deleting the ATDC gene in pancreatic cells resulted in one of the most profound blocks of tumor formation ever observed in a well-known mice model engineered to develop pancreatic ductal adenocarcinoma, or PDA, which faithfully mimics the human disease,” says corresponding author Diane Simeone, MD, director of the Pancreatic Cancer Center of NYU Langone Health’s Perlmutter Cancer Center. “We thought the deletion would slow cancer growth, not completely prevent it.”
The search for better treatment in these cases is especially urgent, says Dr. Simeone, given that PDA has the worst prognosis of any major malignancy and is on track to become the second leading cause of cancer-related death by 2030.
Healing Gone Awry
The study focused on acinar cells in the pancreas that secrete digestive enzymes through a network of partnering ducts into the small intestine. These same digestive enzymes can subject this tissue to low levels of damage. In response, acinar cells have evolved to readily switch back into stem cell types that resemble their high-growth ancestors, a feature that they share with pancreatic duct cells.
This ability to regenerate comes at a price, researchers say, because such cells are prone to become cancerous when they also acquire random DNA changes, including those in the gene KRAS that are known to drive aggressive growth in more than 90 percent of pancreatic cancers.
Specifically, stressed acinar cells are known to temporarily undergo acinar-to-ductal metaplasia, or ADM, a step toward a primitive cell type, to resupply cells. This sets the stage for a second shift into pancreatic intraepithelial neoplasia, or PanIN, in which cells no longer multiply under normal controls.
In the current study, the researchers found that mutant KRAS and other genetic abnormalities induced aggressive pancreatic cancer in 100 percent of study mice when the ATDC gene was present and active, but in none of the same cancer-prone mice lacking the gene. Neither did acinar cells in the ATDC “knock-out” mice undergo ADM or transformation to PanIN.
To get a better look at the early steps in pancreatic cancer formation, the research team artificially caused pancreatitis in mice by treating them with cerulein, a signaling protein fragment that damages pancreatic tissue. ATDC gene expression did not increase right after the damage, but did so a few days later and in line with the timeframe required for acinar cells to reprogram genetically into their ductal cell forebears.
Further experiments confirmed that the expression of ATDC triggers beta-catenin, a cell-signaling protein that, upon receiving the right trigger, activates genes including SOX9. Earlier studies linked SOX9 to the development of ductal stem cells and to the aggressive growth seen in PDA. Consistent with this work, the current study found that the inability of cells lacking ATDCto become cancerous was due to their inability to induce SOX9 expression.
The authors also examined ATDC expression in ADM lesions from 12 samples of human pancreatic tissue. The team found it to be more active in human ADM lesions along with beta-catenin and SOX9, and its activation increased further during the transition of ADM into human pancreatic ductal adenocarcinoma.
The findings, says Dr. Simeone, identify ATDC, beta-catenin, SOX9, and their signaling partners as potential targets in the design of new treatment approaches and prevention strategies for pancreatic cancer.
The Latest on: Pancreatic cancer
via Google News
The Latest on: Pancreatic cancer
- Ruth Bader Ginsburg’s Health Scares and Recoveries, from Surviving Cancer to Fracturing Her Ribson May 7, 2020 at 10:28 am
The Supreme Court justice is a four-time cancer survivor who was first diagnosed back in 1999 Ruth Bader Ginsburg has a long history of health struggles — and overcoming them. The 87-year-old Supreme ...
- Pancreatic Cancer Market Latest Trends, Demand and Analysis 2026on May 7, 2020 at 9:13 am
According to Stratistics MRC, the Global Pancreatic Cancer market is accounted for $1,904.20 million in 2017 and is expected to ...
- Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformationon May 7, 2020 at 2:20 am
Extracellular vesicles secreted from tumor cells are functional vehicles capable of contributing to intercellular communication and metastasis. A growing number of studies have focused on elucidating ...
- NANOBIOTIX Announces First Phase I Trial With NBTXR3 in Pancreatic Cancer Is Safe to Proceed Per US FDAon May 6, 2020 at 10:16 am
Regulatory News: NANOBIOTIX (Paris:NANO) (Euronext: NANO - ISIN: FR0011341205 – the “Company”), a clinical-stage nanomedicine company pioneering new a ...
- Pancreatic Cancer Market Share, Growth, Statistics, by Application, Production, Revenue & Forecast to 2025on May 5, 2020 at 1:10 am
Pancreatic cancer is origins by the unrestrained boom of cells within the pancreas. This atypical, uncontrolled boom of cells results in the formation of lumps of tissue, generally called tumors. The ...
- Activation of estrogen receptor can impede growth of pancreatic cancer cellson May 4, 2020 at 1:16 pm
Activating the G protein-coupled estrogen receptor - a receptor found on the surface of many normal and cancer tissues - has been shown to stop pancreatic cancer from growing, but may also make tumors ...
- MiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamicson May 4, 2020 at 9:48 am
Biomarkers and effective therapeutic agents to improve the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) are urgently required. We aimed to analyze the prognostic value and mechanistic ...
- Activating an estrogen receptor can stop pancreatic cancer cells from growingon May 4, 2020 at 9:34 am
Activating the G protein-coupled estrogen receptor (GPER)—a receptor found on the surface of many normal and cancer tissues—has been shown to stop pancreatic cancer from growing, but may also make ...
- Focused Ultrasound Foundation and Pancreatic Cancer UK Partner to Fund Innovative Studyon April 30, 2020 at 9:00 am
The Focused Ultrasound Foundation and Pancreatic Cancer UK have partnered to advance the development of focused ultrasound therapy as ...
- Erytech Pharma lead drug Fast Track'd for pancreatic cancer, shares up 37%on April 29, 2020 at 11:47 am
Ultra-thinly traded micro cap ERYTECH Pharma S.A. (ERYP +37.0%) is up out of the gate, albeit on turnover of only 13K shares, on the heels of the FDA's granting of Fast Track status for lead drug erya ...
via Bing News