Researchers from King’s have found that therapy that can induce heart cells to regenerate after a heart attack.
Myocardial infarction, more commonly known as a heart attack, caused by the sudden blocking of one of the cardiac coronary arteries, is the main cause of heart failure, a condition that now affects over 23 million population in the world, according to the World Health Organisation.
At present, when a patient survives a heart attack, they are left with permanent structural damage to their heart through the formation of a scar, which can lead to heart failure in the future. In contrast to fish and salamander, which can regenerate the heart throughout life.
In this study, published today in Nature, the team of investigators delivered a small piece of genetic material, called microRNA-199, to the heart of pigs, after a myocardial infarction which resulted in the almost complete recovery of cardiac function at one month later.
Lead author Professor Mauro Giacca from King’s said: “It is a very exciting moment for the field. After so many unsuccessful attempts at regenerating the heart using stem cells, which all have failed so far, for the first time we see real cardiac repair in a large animal.”
This is the first demonstration that cardiac regeneration can be achieved by administering an effective genetic drug that stimulates cardiac regeneration in a large animal, with heart anatomy and physiology like that of humans.
“It will take some time before we can proceed to clinical trials,” said Professor Giacca.
“We still need to learn how to administer the RNA as a synthetic molecule in large animals and then in patients, but we already know this works well in mice.”
Professor Ajay Shah, British Heart Foundation (BHF) Chair of Cardiology and Head of the School of Cardiovascular Medicine and Sciences at King’s said: “A treatment that helps the heart repair itself after a heart attack is the holy grail for cardiologists. Professor Giacca’s study convincingly demonstrates for the first time that this might actually be feasible and not just a pipe-dream.
“It’s a very exciting advance in the field. While we are not yet at a stage where a treatment could be offered to patients, I’m confident that our excellent team in the King’s BHF Centre of Excellence is very well placed to drive forward the research to make such a treatment a reality.”
The Latest on: Heart cell regeneration
via Google News
The Latest on: Heart cell regeneration
- How to live longer: How does fasting increase your life expectancy? What we know so faron February 1, 2020 at 8:00 pm
Autophagy is the body's way of cleaning out damaged cells, in order to regenerate newer, healthier cells ... These mechanisms are precursors to deadly complications, the most threatening being heart ...
- Got slime? Using regenerative biology to restore mucus productionon January 31, 2020 at 2:03 am
She will study how cell motility changes during regeneration and how epithelial cells assemble ... This research was supported by a grant from the National Heart, Lung, and Blood Institute (NHLBI) of ...
- Fish that can repair their OWN HEART: Scientists discover immune cell involvedon January 30, 2020 at 5:58 am
Zebrafish, a Mexican fish, are often the focus of scientific research because they are known to remarkably regenerate their own heart tissue. University of Oxford scientists were 'surprised' to find ...
- Researchers discover new target for repairing heart after heart attackon January 30, 2020 at 5:11 am
Zebrafish, a freshwater fish native to South Asia, is known to be able to fully regenerate its heart after damage due to the formation of a temporary scar as new cardiac muscle cells are formed.
- Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repairon January 30, 2020 at 2:36 am
Fig. 4: Adult monocytes disrupt regeneration of P1 mouse heart and deposit collagen within a post-MI scar. These data suggest that adult mouse monocytes, which give rise to differentiated macrophages ...
- New target identified for repairing the heart after heart attackon January 30, 2020 at 2:08 am
and the zebrafish which can regenerate the heart up to adulthood through forming a transient scar. Professor Paul Riley said: "Efforts to treat heart attack with cell replacement strategies to-date ...
- Mohap and Osaka University join hands to use stem cells for repairing and regenerating heart muscleon January 30, 2020 at 1:51 am
Based on tissue engineering, cells were produced after being grown in specialized human incubators to repair and regenerate the heart muscle The Ministry of Health and Prevention, MoHAP, showcased, at ...
- Lab-grown heart cells implanted into human patient for the first timeon January 29, 2020 at 5:46 pm
who has been developing a technique to turn IPSCs into sheets of 100 million heart muscle cells, which can be grafted onto the heart to promote regeneration of damaged muscles. This was first tested ...
- Lab-grown heart muscles transplanted into a human for the first timeon January 29, 2020 at 6:25 am
Researchers in Japan have successfully carried out the world's first transplant of lab-grown heart muscle cells, in a move which could significantly reduce the need for heart transplants. To grow the ...
- In search for keys to regeneration, scientists ask a lot of the axolotlon January 28, 2020 at 6:12 am
Lose a limb, part of the heart or even a large portion of its brain ... create markers that could track 25 genes suspected of being involved in limb regeneration. The method allowed them to identify ...
via Bing News