A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in The Journal of Clinical Investigation shows.
The effects of the drug, called NV-5138, in rodent models mimicked the rapid actions of the anesthetic ketamine, a variation of which, Esketamine, was recently approved by the FDA for use in depressed patients who do not respond to other medications. However, there still remain lingering safety concerns over use of ketamine, as well as Esketamine, both of which have the potential to induce psychosis-like states and also have a potential for abuse.
“Recent research has raised the possibility that a new drug, such as NV-5138, could be developed that is rapid-acting but also more efficacious and safer than current formulations of ketamine,” said senior author Ron Duman, the Elizabeth Mears and House Jameson Professor of Psychiatry and professor of neuroscience.
The experimental drug does not directly stimulate neuronal activity like ketamine, but like ketamine, it spurs the growth of synapses or connections between neurons, the loss of which is associated with chronic stress and depression. The research team also showed that synaptic connectivity markers were rapidly restored in a mouse model of anhedonia, a core symptom of depression marked by an inability to experience pleasure. Mice administered a single dose of the drug also showed marked improvements in other depression-related behaviors.
The drug is being developed by Navitor Pharmaceuticals Inc., which funded the study. It is currently undergoing Phase I testing in human patients.
The Latest on: Depression
via Google News
The Latest on: Depression
- BlackThorn Therapeutics Reports Data Supporting Phase 2 Development of KOR Antagonist, BTRX-335140, in Depression and Other CNS Disorderson December 11, 2019 at 10:02 am
New results from a positron emission tomography (PET) occupancy study in healthy volunteers confirmed that BTRX-140 engages KORs in the brain at levels that are projected to be effective in treating ...
- Family Dedicated to Anxiety, Depression Awareness After 14 Year Old's Suicide: ‘We Can’t Let Another Family Feel This Kind of Pain’on December 11, 2019 at 8:15 am
A California family who lost their son to suicide following a battle with anxiety and depression knows better than anyone that awareness is key — and now, they’re transforming their grief into good ...
- Snort to Treat Social Anxiety; Zuranolone Flops in Depression Trialon December 11, 2019 at 7:39 am
(ScienceDaily) Having a "safety signal," such as a personal item or song, can help combat and slow down episodes of fear and anxiety. (PNAS) The phase III MOUNTAIN trial for Sage's fast-acting ...
- Fight depression without a pillon December 11, 2019 at 7:26 am
The holidays are a tough time for many people. If you are dealing with depression, there is an alternative out there to help, without the side effects that come with taking a pill. Dr. Nate Upshaw ...
- Study reveals rapid increases in cannabis use among individuals with depressionon December 11, 2019 at 5:51 am
Results of a new study suggest that over the past decade (2005-2017), the prevalence of cannabis use in the United States has increased among persons with and without depression, though the increase ...
- ‘With help, you will get better’: Howard group offers support to those going through postpartum depressionon December 11, 2019 at 5:05 am
As a fax machine buzzed behind the front desk of the clinic, which closes at 4:30 p.m. except for meetings that use the space, support group organizer Jenn Riley welcomed Dodds and other women to the ...
- Sales Scenario of Depression And Seasonal Affective Disorder Therapeutics Market research to Remain Positive Through 2017 – 2027on December 11, 2019 at 12:29 am
Dec 11, 2019 (MARKITWIRED via COMTEX) -- VALLEY COTTAGE, N.Y. - Seasonal Affective Disorder is also referred as winter depression though it comes and goes in the winter season. The symptoms of the ...
- Depression on birth control: Everything you need to knowon December 10, 2019 at 5:06 pm
Some people who use hormonal birth control, such as the pill, the patch, or hormonal intrauterine device (IUD), report experiencing depression as a side effect. Research on the topic has mixed results ...
- Depression during pregnancy: Symptoms, treatment, and moreon December 10, 2019 at 12:09 pm
Depression is a widespread mental health condition. Pregnant women have a higher risk of depression due to increased stress, physical health changes, chemical changes in the body, and other factors.
- Depression at different points in pregnancy may accompany gestational diabeteson December 10, 2019 at 11:44 am
Women who develop gestational diabetes may be more likely than those who do not to experience depression early in pregnancy and after delivery, according to findings published in Diabetic Medicine.
via Bing News