Rice bioengineers lead effort to print scaffolds to heal bone and cartilage
Bioscientists are moving closer to 3D-printed artificial tissues to help heal bone and cartilage typically damaged in sports-related injuries to knees, ankles and elbows.
Scientists at Rice University and the University of Maryland reported their first success at engineering scaffolds that replicate the physical characteristics of osteochondral tissue – basically, hard bone beneath a compressible layer of cartilage that appears as the smooth surface on the ends of long bones.
Injuries to these bones, from small cracks to pieces that break off, can be painful and often stop athletes’ careers in their tracks. Osteochondral injuries can also lead to disabling arthritis.
The gradient nature of cartilage-into-bone and its porosity have made it difficult to reproduce in the lab, but Rice scientists led by bioengineer Antonios Mikos and graduate student Sean Bittner have used 3D printing to fabricate what they believe will eventually be a suitable material for implantation.
Their results are reported in Acta Biomaterialia.
“Athletes are disproportionately affected by these injuries, but they can affect everybody,” said Bittner, a third-year bioengineering graduate student at Rice, a National Science Foundation fellow and lead author of the paper. “I think this will be a powerful tool to help people with common sports injuries.”
The key is mimicking tissue that turns gradually from cartilage (chondral tissue) at the surface to bone (osteo) underneath. The Biomaterials Lab at Rice printed a scaffold with custom mixtures of a polymer for the former and a ceramic for the latter with imbedded pores that would allow the patient’s own cells and blood vessels to infiltrate the implant, eventually allowing it to become part of the natural bone and cartilage.
“For the most part, the composition will be the same from patient to patient,” Bittner said. “There’s porosity included so vasculature can grow in from the native bone. We don’t have to fabricate the blood vessels ourselves.”
The future of the project will involve figuring out how to print an osteochondral implant that perfectly fits the patient and allows the porous implant to grow into and knit with the bone and cartilage.
Mikos said the collaboration is a great early success for the Center for Engineering Complex Tissues (CECT), a National Institutes of Health center at Maryland, Rice and the Wake Forest School of Medicine developing bioprinting tools to address basic scientific questions and translate new knowledge into clinical practice.
“In that context, what we’ve done here is impactful and may lead to new regenerative medicine solutions,” Mikos said.
Learn more: 3D-printed tissues may keep athletes in action
The Latest on: 3D-printed artificial tissues
via Google News
The Latest on: 3D-printed artificial tissues
- New 3D bioprinting technologies to create cardiovascular tissueon March 31, 2020 at 8:16 am
For instance, researchers at University of California San Diego 3D printed a functional blood vessel ... not yet been able to create a fully functioning artificial heart, an important leap was made in ...
- Revision Knee Replacement Market to Witness Robust Expansion throughout the Forecast 2017 – 2027on March 31, 2020 at 6:31 am
VALLEY COTTAGE, N.Y. – Revision knee replacement also known as revision total knee arthoplasty, is a procedure in which already implanted artificial knee joint ... The revision knee replacement ...
- Engineers innovate new soft, flexible brain implanton March 30, 2020 at 6:32 am
Image Credits: Mopic / Shutterstock.com However, current implants are constructed from rigid materials that contrast to the soft tissue of the brain, which can cause inflammation ... the team at MIT ...
- Biomedical Textiles Market Share Worldwide Business Development, Measurement, Statistics, Alternatives & Forecasts as much as 2027on March 27, 2020 at 2:45 am
Implantable biomedical textile is used in arterial grafts, artificial skin and other organs ... The report aims to provide an overview of 3D Printed Medical Implant with detailed market segmentation ...
- Vascularized cardiac tissue construction with orientation by layer-by-layer method and 3D printeron March 26, 2020 at 3:28 am
Herein, we report the fabrication of native organ-like three-dimensional (3D) cardiac tissue with an oriented structure and vascular network using a layer-by-layer (LbL), cell accumulation and 3D ...
- Biomedical Textiles Market to 2027on March 25, 2020 at 4:36 am
Medical textiles involve textiles used in medical applications These should be non allergic non toxic biocompatible and non carcinogenic These are used in the manufacturing of a wide range of products ...
- Researchers Successfully 3D Print and Implant Artificial Trachea without Tissue Scaffolds into Ratson March 24, 2020 at 5:00 pm
Tissue used for tracheal reconstruction ... and the resulting 3D printed, scaffold-free artificial tracheae were matured in a bioreactor, before their mechanical strength was measured and they ...
- Leveraging 3D-printed layers for enhanced tissue repairon March 15, 2020 at 5:00 pm
with cell-seeded implants is a promising approach for tissue regeneration. Now, bioengineers in the Rice Biomaterials Lab have created a 3D-printed scaffold designed to support the growth of complex ...
- Transplantation of a 3D-printed tracheal graft combined with iPS cell-derived MSCs and chondrocyteson March 8, 2020 at 5:00 pm
For successful tracheal reconstruction, tissue-engineered artificial trachea should meet ... nanofibers (inner) and 3D-printed PCL microfibers (outer). Also, human bronchial epithelial cells ...
- Artificial Self-Assembled Blood Vesselson March 4, 2020 at 8:52 am
Made out of graphene oxide and a protein, the material is 3D printed and naturally forms ... Moreover, it was possible to create the artificial vessels with living cells nearby and they showed ...
via Bing News