Rice bioengineers lead effort to print scaffolds to heal bone and cartilage
Bioscientists are moving closer to 3D-printed artificial tissues to help heal bone and cartilage typically damaged in sports-related injuries to knees, ankles and elbows.
Scientists at Rice University and the University of Maryland reported their first success at engineering scaffolds that replicate the physical characteristics of osteochondral tissue – basically, hard bone beneath a compressible layer of cartilage that appears as the smooth surface on the ends of long bones.
Injuries to these bones, from small cracks to pieces that break off, can be painful and often stop athletes’ careers in their tracks. Osteochondral injuries can also lead to disabling arthritis.
The gradient nature of cartilage-into-bone and its porosity have made it difficult to reproduce in the lab, but Rice scientists led by bioengineer Antonios Mikos and graduate student Sean Bittner have used 3D printing to fabricate what they believe will eventually be a suitable material for implantation.
Their results are reported in Acta Biomaterialia.
“Athletes are disproportionately affected by these injuries, but they can affect everybody,” said Bittner, a third-year bioengineering graduate student at Rice, a National Science Foundation fellow and lead author of the paper. “I think this will be a powerful tool to help people with common sports injuries.”
The key is mimicking tissue that turns gradually from cartilage (chondral tissue) at the surface to bone (osteo) underneath. The Biomaterials Lab at Rice printed a scaffold with custom mixtures of a polymer for the former and a ceramic for the latter with imbedded pores that would allow the patient’s own cells and blood vessels to infiltrate the implant, eventually allowing it to become part of the natural bone and cartilage.
“For the most part, the composition will be the same from patient to patient,” Bittner said. “There’s porosity included so vasculature can grow in from the native bone. We don’t have to fabricate the blood vessels ourselves.”
The future of the project will involve figuring out how to print an osteochondral implant that perfectly fits the patient and allows the porous implant to grow into and knit with the bone and cartilage.
Mikos said the collaboration is a great early success for the Center for Engineering Complex Tissues (CECT), a National Institutes of Health center at Maryland, Rice and the Wake Forest School of Medicine developing bioprinting tools to address basic scientific questions and translate new knowledge into clinical practice.
“In that context, what we’ve done here is impactful and may lead to new regenerative medicine solutions,” Mikos said.
Learn more: 3D-printed tissues may keep athletes in action
The Latest on: 3D-printed artificial tissues
via Google News
The Latest on: 3D-printed artificial tissues
- MIT Soft Robotics Control Training Reduces Simulations From 30,000 to 400on November 22, 2019 at 3:53 am
In future soft robots could be 3D printed with varying levels of stiffness… At the Conference on Neural Information ... as surgery where nano-scale robots are tasked with moving through our bodies ...
- Global Artificial Blood Market 2019 Trends, Market Share, Industry Size, Opportunities, Analysis And Forecast To 2025on November 21, 2019 at 6:06 am
By providing a better quality of blood the market of Artificial Blood will grow at a fast pace. October 22, 2019. The latest study on 3D-printed fully functional blood vessels and implanting ...
- Most Important Medical Discoveries Made in 2019on November 19, 2019 at 11:46 pm
Research published in the British Medical Journal studied 350 cases of 3D-printed artificial implants, the majority of which were used in oral ... When your body experiences a trauma, it goes into ...
- Global Artificial Blood Market 2019 Key Players, Trends, Sales, Supply, Demand, Analysis and Forecast 2025on November 18, 2019 at 5:53 am
By providing a better quality of blood the market of Artificial Blood will grow at a fast pace. October 22, 2019. The latest study on 3D-printed fully functional ... and outperform existing engineered ...
- Cells thrive in blood-based bioinkon November 18, 2019 at 1:56 am
(Courtesy: Biofabrication 10.1088/1758-5090/ab33e8) Currently, a wide range of techniques and bioinks are being applied to the goal of 3D-printing artificial tissues and organs. Although each approach ...
- 3D-printed hearts with 'beating' tissue could ease organ donor shortageon September 26, 2019 at 6:37 pm
Scientists at Harvard University developed a new technique that uses living human cells to “print” functional heart tissue for an artificial heart.Sam Lyon / for NBC News ...
- Artificial Tissue Implants: Understanding Cell Adhesion to Polymeric Substanceson September 25, 2019 at 2:14 am
If tissues become damaged, such scaffolds can be 3D-printed to provide temporary stabilization ... For the degradation to be efficient, cells should adhere to the artificial urethral tract, grow into ...
- 3D-printed miniature human heart presents possibilities for future artificial transplantson September 9, 2019 at 11:47 am
The development could mark a significant step forward in the search for a viable artificial heart that can be created ... when it successfully 3D-printed human cardiac tissue. That, combined with a ...
- Scientists develop a new method of creating artificial 3D printed organson September 9, 2019 at 6:32 am
Harvard researchers have created a new method of 3D printing human tissues that could one day lead to 3D printed artificial human organs. The researchers created a new technique called SWIFT ...
- 3D Bioprinting Makes the Imitation Matrix Realon September 3, 2019 at 4:11 am
Building blocks for bioengineered tissues ... 3D-printed polycaprolactone matrices, the only pores are macropores that lack the fine structural features that are needed to support matrix–cell ...
via Bing News