The research group led by Prof. Alex Schier, Director of the University of Basel’s Biozentrum, has identified 30 genes associated with schizophrenia.
The team was able to show which pathological changes in the brain and behavioral abnormalities are triggered by these genes. The results of the study have now been published in Cell.
The research team led by Prof. Alex Schier, Director of the Biozentrum, University of Basel, and currently group leader at Harvard University in Cambridge, investigated a total of 132 genes associated with schizophrenia. The potential connection to schizophrenia was confirmed for 30 genes. In zebrafish, the researchers found that errors in these genes impair the development or function of the brain and lead to behavioral abnormalities.
Regions in the genome under suspicion
Schizophrenia is a psychosis that leads to a disturbed perception of reality. This includes hearing voices, hallucinations or delusions. Although the disease can be treated with medication, it is currently incurable. Genetic changes that manifest themselves in the brain can cause schizophrenia. Previous studies have shown that several regions of the genome containing a variety of genes are associated with the disease.
Perpetrator profile of 30 genes
Alex Schier’s team has now identified 30 genes in these regions and has been able to show that they have concrete effects on the structure and function of the brain as well as on various behavioral patterns. “Of the 132 suspects, we were ultimately able to establish a more precise perpetrator profile for 30 genes,” said Schier. “One of the perpetrators is the transcription factor znf536, which controls the development of the forebrain. This brain region influences our social behavior and the processing of stress.” The research team not only deciphered the function of the individual genes, but also generated an atlas of all genes with their respective consequences for the brain.
In the crosshair of research
“The question of how the individual genes trigger schizophrenia remains open,” says Schier. “It would be possible to investigate whether the genes we identified change similar brain regions in patients as in zebrafish.” These genes and brain regions could then become new targets for drug therapies.
The Latest on: Schizophrenia
via Google News
The Latest on: Schizophrenia
- “Am I going crazy or am I being stalked?” Inside the disturbing online world of gangstalkingon August 7, 2020 at 3:30 am
Forums where people discuss the possibility that they’re being “gangstalked” can push some down a dark path. But they’re often left out of the conversation on the dangers of online misinformation.
- Sonya Hussyn says autism is symptom of schizophrenia, gets schooledon August 7, 2020 at 12:36 am
Sonya Hussyn has landed herself in hot waters thanks to a comment on Instagram. The Ishq Zahe Naseeb actor is all set to star as the lead in the upcoming drama serial, Saraab, based on a schizophrenic ...
- Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoidson August 6, 2020 at 5:11 pm
Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress in single-cell RNA sequencing ...
- Lundbeck’s poor run on schizophrenia trials continues as it cans midstage efforton August 6, 2020 at 4:33 am
Creating new, successful central nervous system drugs is tough, and Lundbeck knows this better than most after canning an internal CNS effort.
- Indoco gets USFDA nod for schizophrenia, bipolar disorder treatment drugon August 5, 2020 at 10:48 pm
Drug firm Indoco Remedies on Thursday said it has received approval from the US health regulator for Olanzapine tablets, indicated for the treatment of schizophrenia and bipolar disorder. The approved ...
- Brunswick police officers kill man with schizophrenia accused of stabbing his mother to deathon July 31, 2020 at 7:33 am
William Sears died in the encounter with police that happened just after 11 p.m. in a home on Alda Parkway just west of Bettie Lane, Brunswick police said in a news release. Brunswick police did not ...
- Schizophrenia Treatment Market Share Report Inlcudes Upcoming Trends and Current Major Strategies of Top Players 2020 to 2024on July 30, 2020 at 5:35 am
Final Report will add the analysis of the impact of COVID-19 on this industry." Global research report on “Schizophrenia Treatment Market” is an overview of the global market which provides with prime ...
- Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesison July 30, 2020 at 4:48 am
Chen, Alhassen et al. show that schizophrenia-like behavioral deficits induced by excessive prenatal methionine administration are due to in-uterus aberrations rather than through early life ...
- Aerobic Exercise May Up Brain-Training Benefits in Schizophreniaon July 29, 2020 at 11:02 am
Adding regular aerobic exercise to cognitive training increases its effect on cognition and function in patients with schizophrenia, new research suggests. However, adherence remains an issue.
- People with delusions understand metaphor differently – here's how it could help explain schizophreniaon July 27, 2020 at 4:32 am
Figurative language, by which the speaker intends to communicate something other than what is actually said by the words used, is commonplace in human communication. Some claim that metaphorical ...
via Bing News