The research group led by Prof. Alex Schier, Director of the University of Basel’s Biozentrum, has identified 30 genes associated with schizophrenia.
The team was able to show which pathological changes in the brain and behavioral abnormalities are triggered by these genes. The results of the study have now been published in Cell.
The research team led by Prof. Alex Schier, Director of the Biozentrum, University of Basel, and currently group leader at Harvard University in Cambridge, investigated a total of 132 genes associated with schizophrenia. The potential connection to schizophrenia was confirmed for 30 genes. In zebrafish, the researchers found that errors in these genes impair the development or function of the brain and lead to behavioral abnormalities.
Regions in the genome under suspicion
Schizophrenia is a psychosis that leads to a disturbed perception of reality. This includes hearing voices, hallucinations or delusions. Although the disease can be treated with medication, it is currently incurable. Genetic changes that manifest themselves in the brain can cause schizophrenia. Previous studies have shown that several regions of the genome containing a variety of genes are associated with the disease.
Perpetrator profile of 30 genes
Alex Schier’s team has now identified 30 genes in these regions and has been able to show that they have concrete effects on the structure and function of the brain as well as on various behavioral patterns. “Of the 132 suspects, we were ultimately able to establish a more precise perpetrator profile for 30 genes,” said Schier. “One of the perpetrators is the transcription factor znf536, which controls the development of the forebrain. This brain region influences our social behavior and the processing of stress.” The research team not only deciphered the function of the individual genes, but also generated an atlas of all genes with their respective consequences for the brain.
In the crosshair of research
“The question of how the individual genes trigger schizophrenia remains open,” says Schier. “It would be possible to investigate whether the genes we identified change similar brain regions in patients as in zebrafish.” These genes and brain regions could then become new targets for drug therapies.
The Latest on: Schizophrenia
via Google News
The Latest on: Schizophrenia
- Growth control, or Hilton Head’s ‘schizophrenia,’ dominates the news over past 50 yearson July 9, 2020 at 1:52 am
Staff file photo Growth control and its built-in “schizophrenia” have dominated the pages of The Island Packet over its first 50 years. Born in a carefully planned setting of original developers ...
- Demand for Schizophrenia Treatment Market Set for Stupendous Growth in and Post 2026, Buoyed by the Global COVID-19 Pandemicon July 8, 2020 at 9:22 am
VALLEY COTTAGE, N.Y. – Future Market Insights (FMI)’s upcoming research study on the Global Schizophrenia Treatment Market lays bare undercurrents and opportunities for key Market stakeholders. The ...
- Cariprazine Significantly Improved Negative Symptoms of Schizophrenia Based on Real Life Data from a New Observational Study by Gedeon Richter Plcon July 8, 2020 at 2:27 am
July 2020, during the 28th Annual Meeting of the European Psychiatric Association (EPA) – which was held virtually due to the COVID-19 pandemic situation – new analysis of cariprazine studies in ...
- The U.S. is Set to Execute a Man with Schizophrenia and Alzheimer's. He Won't Even Know Why | Opinionon July 3, 2020 at 5:30 am
Wesley Purkey has schizophrenia, brain damage, bipolar disorder, Alzheimer's and dementia. The Constitution requires the prisoner to understand why he is being executed. He clearly doesn't meet that ...
- Association between Serum Essential Metal Elements and the Risk of Schizophrenia in Chinaon July 3, 2020 at 2:12 am
Numerous essential metal elements (EMEs) are necessary to maintain the proper function of human body. In this case-control study, we investigated the associations of 11 EMEs [Calcium (Ca), potassium ...
- 2020 Insights into the Global Schizophrenia Market and Competitive Landscape - ResearchAndMarkets.comon July 2, 2020 at 8:06 am
The "Global Schizophrenia Market and Competitive Landscape - 2020" report has been added to ResearchAndMarkets.com's offering.
- Andrew Toles diagnosed with bipolar disorder and schizophreniaon July 1, 2020 at 1:32 pm
Dodgers outfielder Andrew Toles has been diagnosed with the mental illnesses bipolar disorder and schizophrenia. He was recently arrested for trespassing.
- New Analysis of fMRI Data May Hone Schizophrenia Treatmenton July 1, 2020 at 3:30 am
In a new study, researchers from the University of Maryland, Baltimore County (UMBC) have developed tools to improve the analysis of functional magnetic resonance imaging (fMRI) data, and as a result ...
- People with delusions understand metaphor differently – here’s how it could help explain schizophreniaon July 1, 2020 at 2:37 am
People with a diagnosis of schizophrenia will have been, just like anyone else, exposed to non-literal language from childhood. But research suggests that they have difficulty accurately interpreting ...
- Using prefrontal transcranial direct current stimulation (tDCS) to enhance proactive cognitive control in schizophreniaon June 30, 2020 at 5:33 am
The goal of this study was to use transcranial direct current stimulation (tDCS) to examine the role of the prefrontal cortex (PFC) in neural oscillatory activity associated with proactive cognitive ...
via Bing News