Autophagy is an important biological recycling mechanism that is used to maintain homeostasis (balance or equilibrium) within all types of animal tissue. Many studies have attempted to understand the relationship between the reduction of autophagy and progression of aging in animals; however, none have provided a clear explanation, until now.
In 2009, a research team led by Tamotsu Yoshimori at Osaka University identified Rubicon as a protein factor that suppresses autophagy by controlling a specific step in this pathway. This time, the team found that Rubicon expression levels increased in an age-related manner in worm, fly, and mouse tissues, publishing their findings in Nature Communications.
Autophagy allows degradation of damaged cellular components and helps to avoid the onset of a variety of diseases related to cellular stress and dysfunction, including cancer, neurodegenerative diseases, and metabolic syndromes. Reduced autophagy has recently been linked to progression of aging in animals. While a variety of methods can increase autophagy in aged animals, thereby slowing the aging process, there has been no definite finding regarding the underlying cause of naturally reduced autophagy.
“Rubicon has been linked to inhibition of the autophagic process, and knockout of Rubicon in mice helped to mitigate autophagy-related liver diseases,” says Yoshimori. “Therefore, we suspected that Rubicon may directly affect aging through its interaction with autophagy.”
In the study, increased levels of Rubicon were found in tissues from multiple aged model organisms (worms, flies, and mice). When the researchers suppressed Rubicon expression, all model organisms demonstrated increased autophagy activity, which led to improvement of multiple age-related factors and slightly increased lifespan in worms and flies.
“Our analyses revealed that Rubicon suppression in model organisms led to reduction of age-associated motor decline, as well as reduction of fibrosis,” says Shuhei Nakamura, lead author on the study. “Importantly, we found that Rubicon suppression enabled aged mice to resist attempts to induce Parkinson’s disease.”
The findings in this study suggest that, because elevated levels of Rubicon lead to reduced autophagy in aged animals, suppression of Rubicon may be critical in extending healthy lifespan in humans.
The Latest on: Aging
via Google News
The Latest on: Aging
- Stingl: Buried under a zillion old telephones, aging couple's retirement plans are on holdon August 16, 2019 at 1:28 pm
Most of us interact with one telephone at a time — a desk phone at work, a landline at home if that's still your thing, the addictive smartphone likely in your hand right now. On Wednesday, I waded ...
- Robert J Winn on Self-Care While Caring for Your Aging Parentson August 16, 2019 at 10:54 am
You love your parents, but caring for them as they age can seem like a full-time job. As they begin to decline, you end up taking over more of the tasks that they used to be able to do on their own.
- ‘Don’t take the brown antacid’: aging hippies flash back to Woodstockon August 16, 2019 at 8:43 am
“I gave her a peck on the cheek, and that was our sex for the weekend,” the softspoken 69-year-old said with a wide smile, his framed original tickets in hand. Two years after falling for each other ...
- Aging Investors Want to Know: What’s the Actual Impact of My Impact Investing?on August 16, 2019 at 8:16 am
Everyone’s talking about impact investments — but there needs to be more discussion of the actual impact. While inspiring stories about fund managers and how funds are deployed used to be enough, the ...
- Aging technology could slow Kansas services, jeopardize data security. Fixes are costlyon August 16, 2019 at 3:00 am
The technology that makes Kansas government operate is outdated and deteriorating — and the state will have to spend millions to fix it. Old systems could complicate getting a drivers license or ...
- West Health's Shelley Lyford Appointed to California's Master Plan for Aging Stakeholder Advisory Committeeon August 15, 2019 at 5:05 pm
SAN DIEGO, Aug. 15, 2019 /PRNewswire/ -- Shelley Lyford, president and CEO of nonprofit, nonpartisan West Health and a commissioner on the California Commission on Aging, has been appointed to ...
- The Aging Spacecraft of Deep Spaceon August 15, 2019 at 11:37 am
Beyond Earth and its bubble of satellites; past Mars, where rovers explore; past Jupiter and its circling orbiter—outside the solar system entirely—two spacecraft are gliding across interstellar space ...
- Art of Aging: Once Upon a Nation storytelling programon August 15, 2019 at 9:55 am
PHILADELPHIA (WPVI) -- If you still haven't crossed off a historic trip to Philadelphia from your bucket list - put on your walking shoes and head to the historic district. You will find knowledge ...
- Shoppers Can’t Stop Buying This Anti-Aging Eye Cream — Now on Sale!on August 15, 2019 at 8:21 am
We love summer, but there’s one major aspect that we hate about it: How it ages our skin! The sun’s rays feel so good and we want to soak them all up while we can, but ultimately, they’re our skin’s ...
- Anti-aging breakthrough could reverse rat brain stem cells aging processon August 15, 2019 at 7:10 am
Scientists at Cambridge University have conducted research that shows that increasing brian stiffness as we age causes brain stem cell dysfunction. The scientists have also demonstrated a way to ...
via Bing News