The findings — focused on components contained in green tea and carrots — lend credence to the idea that certain readily available, plant-based supplements might offer protection against dementia in people.
A diet containing compounds found in green tea and carrots reversed Alzheimer’s-like symptoms in mice genetically programmed to develop the disease, USC researchers say.
Researchers emphasize that the study, published in the Journal of Biological Chemistry, was in mice, and many mouse discoveries never translate into human treatments. Nevertheless, the findings lend credence to the idea that certain readily available, plant-based supplements might offer protection against dementia in humans.
“You don’t have to wait 10 to 12 years for a designer drug to make it to market; you can make these dietary changes today,” said senior author Terrence Town, a professor of physiology and neuroscience at the Keck School of Medicine of USC’s Zilkha Neurogenetic Institute. “I find that very encouraging.”
Diet and Alzheimer’s: Combination therapy
What’s more, the study supports the idea that combination therapy, rather than a single magic bullet, may offer the best approach to treating the 5.7 million Americans living with Alzheimer’s. Combination treatment is already the standard of care for diseases such as cancer, HIV infection and rheumatoid arthritis.
For this study, the researchers took a look at two compounds, EGCG, or epigallocatechin-3-gallate, a key ingredient in green tea, and FA, or ferulic acid, which is found in carrots, tomatoes, rice, wheat and oats.
The researchers randomly assigned 32 mice with Alzheimer’s-like symptoms to one of four groups with an equal number of males and females. For comparison, each group also included an equal number of healthy mice. For three months, the mice consumed a combination of EGCG and FA, or EGCG or FA only, or a placebo. The dosage was 30 milligrams per kilogram of body weight — a dosage well-tolerated by humans and easily consumed as part of a healthy diet.
Diet and Alzheimer’s: Testing results
Before and after the three-month special diet, scientists ran the mice through a battery of neuropsychological tests that are roughly analogous to the thinking and memory tests that assess dementia in humans. Of particular note was a maze in the shape of a Y, which tests a mouse’s spatial working memory — a skill that humans use to find their way out of a building.
Healthy mice instinctively explore each arm of the Y maze, looking for food or a route to escape and entering the three arms in sequence more often than by chance alone. Impaired mice can’t do this as well as their mentally healthy counterparts.
“After three months, combination treatment completely restored spatial working memory and the Alzheimer’s mice performed just as well as the healthy comparison mice,” Town said.
How did it work? Town says one mechanism appeared to be the substances’ ability to prevent amyloid precursor proteins from breaking up into the smaller proteins called amyloid beta that gum up Alzheimer patients’ brains. In addition, the compounds appeared to reduce neuroinflammation and oxidative stress in the brain—key aspects of Alzheimer’s pathology in humans.
Town said he and his lab will continue exploring combination treatment, with a focus on plant-derived substances that inhibit production of the sticky amyloid beta plaques.
The Latest on: Plant-based supplements
via Google News
The Latest on: Plant-based supplements
- Are Meatless Burgers Really Healthier?on August 16, 2019 at 11:12 am
In addition, “while we can’t measure phytonutrients — the plant-based antioxidants, vitamins and minerals that are present in plants — it is likely that meatless burgers won’t contain ...
- Six High-Protein, Plant-Based Foods to Add to Your Dieton August 16, 2019 at 7:16 am
Their plant-based ground beef allows you to enjoy the product in whichever ... Each bottle has 400 calories, 26 vitamins and minerals, and 20 grams of protein and is engineered using high-quality ...
- Qatar- Athletes are winning with Vegan dieton August 15, 2019 at 10:24 pm
A plant-based diet also incorporates a greater amount of healing antioxidants, proteins, as well as essential vitamins and minerals that help the body's process of muscle synthesis and help ...
- Lifeway Foods Launches Plant-Based Frozen Probiotic Plantiful at The Lifeway Kefir Shopon August 13, 2019 at 1:18 pm
Plantiful is a plant-based, dairy-free beverage with 10 cultures of live and ... specialty cheeses, probiotic supplements and a ProBugs line for kids. Lifeway's tart and tangy fermented dairy and ...
- Plant Based Protein Supplements Market Worth USD 7.70 Billion by 2025: Grand View Researchon August 12, 2019 at 10:31 pm
SAN FRANCISCO: The global plant based protein supplement market size is expected to reach USD 7.70 billion by 2025, according to a new report by Grand View Research, Inc. It is anticipated to expand ...
- The best B12 supplementon August 10, 2019 at 2:59 pm
Thankfully, there are many B12 supplement options on the market ... Plants don't contain B12, so anyone on a primarily plant-based diet (vegetarians and vegans) may potentially develop a deficiency if ...
- Plant-based burgers are hot, but are they healthier?on August 8, 2019 at 7:18 am
But the plant-based protein in these burgers ... but only every once in a while. CBD oils, edibles, and supplements may be all the rage, but experts warn: check the label, or it could cost you a job.
- Environmentally Optimal, Nutritionally Sound, Protein and Energy Conserving Plant Based Alternatives to U.S. Meaton August 8, 2019 at 6:12 am
Conversely, the replacement plant based diets require additional irrigation that amounts ... and energy (associated with upper bounds), and monounsaturated fatty acid, vitamins D, B 3,12, zinc, ...
- What is plant-based meat? Here are our top 10 product pickson August 7, 2019 at 1:57 pm
The plant-based burger that bleeds has a special secret ingredient that's the key to it cooking, smelling, and tasting like real beef: heme, which is found in animals and all plants. Impossible ...
- The best plant-based protein powderon August 7, 2019 at 4:29 am
You can find certified organic plant-based protein powders on the market, which is great for anyone who prefers to consume organic foods. Check out the other nutrition values of your chosen protein ...
via Bing News