The findings — focused on components contained in green tea and carrots — lend credence to the idea that certain readily available, plant-based supplements might offer protection against dementia in people.
A diet containing compounds found in green tea and carrots reversed Alzheimer’s-like symptoms in mice genetically programmed to develop the disease, USC researchers say.
Researchers emphasize that the study, published in the Journal of Biological Chemistry, was in mice, and many mouse discoveries never translate into human treatments. Nevertheless, the findings lend credence to the idea that certain readily available, plant-based supplements might offer protection against dementia in humans.
“You don’t have to wait 10 to 12 years for a designer drug to make it to market; you can make these dietary changes today,” said senior author Terrence Town, a professor of physiology and neuroscience at the Keck School of Medicine of USC’s Zilkha Neurogenetic Institute. “I find that very encouraging.”
Diet and Alzheimer’s: Combination therapy
What’s more, the study supports the idea that combination therapy, rather than a single magic bullet, may offer the best approach to treating the 5.7 million Americans living with Alzheimer’s. Combination treatment is already the standard of care for diseases such as cancer, HIV infection and rheumatoid arthritis.
For this study, the researchers took a look at two compounds, EGCG, or epigallocatechin-3-gallate, a key ingredient in green tea, and FA, or ferulic acid, which is found in carrots, tomatoes, rice, wheat and oats.
The researchers randomly assigned 32 mice with Alzheimer’s-like symptoms to one of four groups with an equal number of males and females. For comparison, each group also included an equal number of healthy mice. For three months, the mice consumed a combination of EGCG and FA, or EGCG or FA only, or a placebo. The dosage was 30 milligrams per kilogram of body weight — a dosage well-tolerated by humans and easily consumed as part of a healthy diet.
Diet and Alzheimer’s: Testing results
Before and after the three-month special diet, scientists ran the mice through a battery of neuropsychological tests that are roughly analogous to the thinking and memory tests that assess dementia in humans. Of particular note was a maze in the shape of a Y, which tests a mouse’s spatial working memory — a skill that humans use to find their way out of a building.
Healthy mice instinctively explore each arm of the Y maze, looking for food or a route to escape and entering the three arms in sequence more often than by chance alone. Impaired mice can’t do this as well as their mentally healthy counterparts.
“After three months, combination treatment completely restored spatial working memory and the Alzheimer’s mice performed just as well as the healthy comparison mice,” Town said.
How did it work? Town says one mechanism appeared to be the substances’ ability to prevent amyloid precursor proteins from breaking up into the smaller proteins called amyloid beta that gum up Alzheimer patients’ brains. In addition, the compounds appeared to reduce neuroinflammation and oxidative stress in the brain—key aspects of Alzheimer’s pathology in humans.
Town said he and his lab will continue exploring combination treatment, with a focus on plant-derived substances that inhibit production of the sticky amyloid beta plaques.
The Latest on: Plant-based supplements
via Google News
The Latest on: Plant-based supplements
- 10 Foods That Can Literally Kill Youon July 4, 2019 at 2:20 pm
We all know that food nourishes us and gives us all the vitamins and minerals our bodies need to get ... and it’s gaining a lot of popularity as a source of protein for those on plant based diets. ... […]
- 14 Best Vegan Omega 3 Supplementson July 4, 2019 at 5:02 am
Freshfield Naturals’ Vegan Omega 3 DHA Supplement uses only pure plant-based vegan Omega-3 DHA and is absolutely mercury-free. This product also contains DPA which optimizes and intensifies the ... […]
- Global Plant Based Protein Supplements Market 2018 exhibiting a CAGR of 8.1%on July 3, 2019 at 10:57 pm
Jul 04, 2019 (Aperture Games via COMTEX) -- Global Plant Based Protein Supplements Market contains holistic business information and changing trends in the market, providing an in-depth study of Plant ... […]
- Best weight loss supplements: The plant-based supplement proven to burn faton July 2, 2019 at 1:55 pm
Weight loss is best achieved through eating a healthy balanced diet and regular exercise. For people who are overweight, losing weight can be beneficial to their health, slashing the risk of serious ... […]
- Emerald Health Therapeutics Joint Venture Launches Cannabis-Free Endocannabinoid-Supporting Health Supplement in Canadaon July 2, 2019 at 4:00 am
These products feature PhytoCann® Complex, a proprietary formulation consisting of non-psychoactive, plant-based bioactive ... to this new nutritional supplement as an alternative to existing ... […]
- Best supplements for the brain: The plant-based capsule proven to boost cognitive functionon July 1, 2019 at 3:26 pm
The brain is an important part of the body to take care as it controls almost everything we do. It performs critical function in controlling the heart, breathing and consciousness. A healthy diet has ... […]
- Go with your gut -- USANA earns seal of approval for Digestive Enzyme supplementon July 1, 2019 at 9:05 am
Digestive enzyme supplements help to naturally support ... "USANA's Digestive Enzyme features a broad range of plant-based enzymes and artichoke extract. Together, these ingredients help you ... […]
- Vitasave as the Hub of Vitamin Supplementson July 1, 2019 at 12:35 am
Supplements that has Natural Pigments The plant pigment like ... People always ask Natural Factors Vitamin C - Calcium Ascorbate Powderas it has an immense usage. It is a plant based product and ... […]
- The best biotin supplementon June 29, 2019 at 7:15 am
but will instead use the plant-based alternative pectin. Additives, fillers, and binders "Inactive" ingredients found in supplements are called additives, fillers, and binders. They can have adverse ... […]
- Arby's Is Rejecting The Plant-Based Burger Movement With Meat That Looks Like Vegetableson June 26, 2019 at 5:06 pm
Nearly every restaurant is jumping aboard the plant-based food trend. Well ... According to the company, the Megetable has the same vitamins of a raw carrot and the same look of a raw carrot, but is ... […]
via Bing News