In part because of its resistance to many antibiotics, tuberculosis kills approximately 1.7 million people worldwide each year. But new research from the University of Notre Dame suggests that structures released by the infected cells may be used in tandem with antibiotics to boost the body’s immune system, helping fight off the disease.
The paper, published in EMBO Reports by Jeffrey Schorey, the George B. Craig Jr. Professor, and Yong Cheng, research assistant professor, both in the Department of Biological Sciences, describes how the structures, called extracellular vesicles (EVs), contain Mycobacterium tuberculosis RNA and transfer it to other cells. This starts a built-in weapon system against the disease in the form of an immune response.
Though extracellular vesicles containing RNA from viruses had been discovered years ago, Schorey and his collaborators recently discovered RNA from bacteria — Mycobacterium tuberculosis — in EVs. This discovery led to experiments described in the EMBO Reports paper to determine how the bacteria’s RNA was affecting the “target” cell, including cells infected by M. tuberculosis.
A key research discovery hinges on macrophages, which are cells of the immune system. These cells, when treated with EVs released from M. tuberculosis-infected cells, can control the infection better than macrophages not previously exposed to the EVs, Schorey and Cheng determined. “It had never before been shown that bacterial RNA in EVs can activate this sensing pathway, one that has primarily been thought to be involved in viral sensing,” Schorey said. The authors then show that EV-treated macrophages produce compounds like reactive oxygen species that can promote the killing of the M. tuberculosis once it infects the macrophage.
The discovery is important because it can lead to future therapies for treatment of tuberculosis. Preliminary data in the paper suggest that antibiotics might work better when combined with an immunotherapy based on using these EVs. The data from the mouse model showed that more of the bacterial-infected cells were killed with the combination of therapies than either antibiotics or EVs alone, Schorey noted.
The next steps for future research are to try this approach with other laboratory models, with the goal that they also show the benefit of combining EVs, as immunotherapy treatments, with antibiotics to treat drug-resistant tuberculosis.
Worldwide, more than 10 million people develop active tuberculosis each year. Furthermore, over two billion people are infected with the bacteria. This results in a reservoir of infected people who may develop disease if their immune systems are compromised.
The Latest on: Tuberculosis
via Google News
The Latest on: Tuberculosis
- AHS warns of possible tuberculosis exposure at Calgary day care on April 17, 2019 at 10:43 am
Alberta Health Services says dozens of children and their parents may have been exposed to tuberculosis at a Calgary day care. The provincial health authority sent letters to 150 people Wednesday ... […]
- Confirmed tuberculosis case at Calgary daycare prompts alert from AHS on April 17, 2019 at 10:37 am
Alberta Health Services announced Wednesday that it has issued 150 letters to people who may have been exposed, or had their child exposed, to tuberculosis at an unidentified Calgary daycare. The only ... […]
- Alberta Health Services says 150 people potentially exposed to tuberculosis at Calgary daycare on April 17, 2019 at 9:56 am
CALGARY — Alberta Health Services says 150 people — including children — may have been exposed to a confirmed case of tuberculosis in the Calgary area. The agency issued notification letters on ... […]
- Children at Calgary daycare potentially exposed to tuberculosis: AHS on April 17, 2019 at 9:51 am
Alberta Health Services (AHS) announced Wednesday that children at a Calgary daycare may have been exposed to tuberculous (TB). Letters were sent to 150 people, notifying them that their child could ... […]
- Tuberculosis exposure at Calgary-area daycare prompts warning letters from AHS on April 17, 2019 at 9:23 am
Notification letters have been sent to 150 individuals after parents and children were potentially exposed to a confirmed case of tuberculosis at a Calgary-area daycare. “Notification letters ... […]
- Tuberculosis: India’s Silent Epidemic on April 17, 2019 at 6:18 am
Aditi (name changed), 18, sat cross-legged on her private hospital bed in Kolkata. The black scarf covering her mouth did little to hide her emaciated face. Cheeks stained with long-dried tears ... […]
- Tuberculosis patients safely transported by Global Air Ambulance Chennai to CMC Vellore on April 17, 2019 at 6:11 am
(MENAFN - Global Air Ambulance) Wednesday, April 17, 2019:- Let's get some information about tuberculosis infections, so we all know that it is a bacterial infection and a serious issue that does ... […]
- Student at Monroe College in New Rochelle diagnosed with tuberculosis on April 16, 2019 at 7:00 pm
NEW ROCHELLE, Westchester County (WABC) -- A student at a college in Westchester County has been diagnosed with tuberculosis. The county health department said the student at Monroe College in New ... […]
- Westchester College Student Diagnosed With Tuberculosis: Health Department on April 16, 2019 at 6:02 pm
A student at a college in Westchester County has been diagnosed with active tuberculosis, the county’s health department said. The student, who attends Monroe College’s New Rochelle campus, is ... […]
- For centuries, scientists sought a tuberculosis cure. A Passaic man found it in the dirt. on April 16, 2019 at 5:25 pm
For centuries, scientists sought a tuberculosis cure. A Passaic man found it in the dirt. Growing up in Passaic, Albert Schatz saw his neighbors die of tuberculosis. He found the cure, and changed ... […]
via Bing News