A James Cook University scientist is part of an international team that’s used new ‘big data’ analysis to achieve a major advance in understanding neurological disorders such as Epilepsy, Alzheimer’s and Parkinson’s disease.
Dr Ashley Waardenberg, a Theme Leader from JCU’s Centre for Tropical Bioinformatics and Molecular Biology, said scientists from JCU, The Children’s Medical Research Institute, Sydney, University of Southern Denmark and Bonn University (Germany) looked at how neurons in the brain communicated with each other.
“We studied the synapse – the communication hotspot between neurons – which is a place where neurological disorders and diseases can interfere with the brain’s normal functions,” said Dr Waardenberg.
“We aimed to use new methods for mapping the protein pathways that neurons use to communicate with each other (neurotransmission) and tried to see if we could identify patterns of activity related to memory.”
“A key part of the project that I led was to develop new computational methods to assess the very large amount of data that we collected. This led to the discovery of the major proteins responsible for the changes observed in the neurons,” said Dr Waardenberg.
He said the discoveries open up many new avenues for studying the protein pathways underlying neurotransmission and how they might be linked to neurological diseases and disorders.
Dr Waardenberg said the breakthrough demonstrates how new computational methods are needed to develop insights from ‘big data’.
He said the team of scientists is releasing the paper detailing the computational methods and the thousands of new proteins sites identified as a resource to the scientific community.
“We hope that this resource will help our future understanding of neuron signaling and memory. The discovery has very important implications for understanding the mechanisms of neurotransmission and neurological disorders,” he said.
Dr Waardenberg is now aiming to establish these new methods at JCU and continue to develop new computational methods for tackling tropical diseases such as malaria.
Learn more: Big data takes aim at a big human problem
The Latest on: Big data
via Google News
The Latest on: Big data
- Video: Big Data is Dead, Long Live Its Replacementon August 16, 2019 at 8:09 am
In this video, Tom Fisher presents: Big Data is Dead, Long Live Its Replacement. Big Data is experiencing a second revolution. This talk will address what’s happened, how it happened and what big data ...
- OneConnect Launches the first end-to-end Big Data-based Data Governance Solution in Chinaon August 16, 2019 at 5:08 am
GUILIN, China, Aug 15, 2019 /PRNewswire/ -- OneConnect Financial Technology Co., Ltd. ("OneConnect" or "the Company"), a leading technology-as-a-service platform for financial institutions in ...
- Data Driven Decision Making Fueling Big Data Adoptionon August 16, 2019 at 4:52 am
Big data is considered as the next huge transformation in data management and analysis. Many businesses around the world have employed big data technology in their operations to help them analyze the ...
- Accenture Acquires Big Data Consulting Firm Analytics8on August 15, 2019 at 2:42 pm
Accenture acquires Australian big data consultancy Analytics8 as part of $1.5 billion digital transformation, cloud & cybersecurity acquisition for 2019. Accenture continues to follow through with its ...
- Big Promises, Big Data: Is the SAT’s New ‘Environmental Context’ Score a Tool to Personalize College Admissions, or Anotheron August 15, 2019 at 7:40 am
Kerr: As a Teacher, I Know That Working With Students, Not Punishing Them, Is the Best Way to Manage a School. My Colleagues Agree Linehan: Meet 7 Young Education Reformers Who Flourished Thanks to ...
- Big Data Shines Way Forward for Big Quake Predictionon August 14, 2019 at 7:21 pm
The magnitude 6.4 earthquake that struck near Ridgecrest, California on July 4 was an eye opener for many in the region. But when a much larger magnitude 7.1 quake hit the following day, it became ...
- The Controlling Power Of Big Dataon August 14, 2019 at 9:54 am
I’m working this morning on the chapter of my new book in which I talk about how the power and ubiquity of data mining, and the technology that supports it, puts us in an unprecedented position ...
- How big data and AI help online retailers compete in the digital eraon August 14, 2019 at 7:00 am
Personalized data offers e-commerce yet another advantage over brick-and-mortar retail stores. As brick-and-mortar retailers continue to struggle against online competitors, some are seeking out ...
- Artificial intelligence predicts the progression of diabetic kidney disease using big data machine learningon August 14, 2019 at 2:20 am
Artificial intelligence (AI) is expected to support clinical judgement in medicine. We constructed a new predictive model for diabetic kidney diseases (DKD) using AI, processing natural language and ...
- A ‘big data’ firm sells Cambridge Analytica’s methods to global politicians, documents showon August 14, 2019 at 12:00 am
Cambridge Analytica, the most notorious practitioner of psychological profiling, has closed shop. Their methods aren’t about to die out so easily. A pitch deck from IDEIA Big Data, an ...
via Bing News