Medical care for older adults has long focused on preventing and treating chronic diseases and the conditions that come with them. But now, geriatrics researchers and clinicians hope a new understanding—one honed at a prestigious conference hosted by the American Geriatrics Society (AGS) and the National Institute on Aging (NIA), with support from The John A. Hartford Foundation—can lead to better and more effective interventions by targeting the aging process itself rather than discrete conditions or concerns.
“Aging is complex and varies from one person to the next, but there’s a growing body of evidence that aging itself is driven by interconnected biological factors we call ‘hallmarks’ or ‘pillars,’” said Christopher Carpenter, MD, MSc, FACEP, FAAEM, AGSF, one of the co-authors of a report on the conference. “We believe disrupting these hallmarks—which cover everything from the stability of our genes to ways our cells communicate—can contribute to chronic disease and frailty, which is why a better understanding of how they work is so important.”
Convened in 2016 as the second conference in a three-part series for recipients of the NIA’s Grants for Early Medical/Surgical Specialists Transition into Aging Research (GEMSSTAR) program, the NIA “U13” conference brought together more than 100 scholars, researchers, leaders representing 19 medical specialties, and NIA representatives to stimulate research across the disciplines involved in high-quality, person-centered care. Conference findings, published in the Journal of the American Geriatrics Society (DOI: 10.1111/jgs.15788), detail how new methods of studying the older-adult population can reveal new tools and accelerate innovative treatments focused on big-picture outcomes important to people’s lives, such as function and independence.
Rather than beginning with the discrete health conditions and concerns common among older adults, conference organizers took the unique approach of focusing on aging itself as a primary factor impacting multiple chronic diseases and the declining ability to rebound from health challenges (also known as “resilience”). In doing so, GEMSSTAR scholars advanced our understanding of the concept that targeting age-related mechanisms might delay, prevent, or even reverse geriatric syndromes, age-related chronic diseases, and declines in resilience. Conference sessions also focused on new methods and strategies for studying these aspects of aging, and reviewed the challenges of studying age when older people often have been excluded from medical research.
Major themes that emerged from the conference include a need for increased attention to:
- The study of our human population as it ages. Most clinical trials still look for people who are “ideal,” such as people who do not have chronic diseases. However, researchers now understand the importance of ensuring pragmatic clinical trials reflect the full spectrum of health for older adults, particularly those who are frail. These individuals often are the most likely to live with multiple chronic diseases, which can be treated best when we understand how medications and other interventions will affect “real” as opposed to “ideal” people.
- The need for new tools to help older adults and caregivers adapt to changing health needs. Studying the biology of aging could yield even more approaches to aging-related disease prevention or treatment for geriatrics experts who will be needed in greater numbers as the world continues to age. For example, geriatrics health professionals are already adept at streamlining medication management for common conditions such as diabetes and high blood pressure. A better understanding of the interactions of resilience, metabolism, and inflammation with aging, however, could deepen these clinicians’ hypothesis that many common medicines prescribed for these conditions could play a role in supporting general health as we age.
- The importance of accelerating how we translate research into promising clinical practice. Conference workshops also focused on ways to make aging research actionable for clinical studies and clinical practice. For example, suggestions included integrating aging concepts into research conducted by “subspecialists” in particular areas of medicine; creating a national, diverse “geroscience biobank” attuned to exploring multimorbidity and frailty in particular; incorporating “precision medicine” as a catalyst for individualized healthcare delivery; using existing databases like the Baltimore Study of Longitudinal Aging to forge collaborations and inform early-stage hypotheses; and creating a standardized “outcomes toolkit” to help bridge the gap between studies of aging and supports for our well-being as we age.
- Supporting the future of aging research. As more and more people benefit from increased longevity, specialty clinician-investigators—so named for their expertise in caring for patients and researching how that care takes shape—must be empowered to contribute to the evolution of aging research. Collaboration will be particularly important, said Evan Hadley, MD, Director of the Division of Geriatrics and Clinical Gerontology at the NIA, in his closing remarks for the GEMSSTAR U13 conference. Dr. Hadley emphasized that partnering across disciplines previously seen as independent will be important to future progress, which is why the GEMSSTAR community offered such an important outlet for beginning these discussions.
The Latest on: Aging process
via Google News
The Latest on: Aging process
- Patients push for safeguards in drug step therapy process on April 17, 2019 at 1:25 pm
The measure addresses the process known as step therapy ... the Wisconsin Medical Society and the Coalition of Wisconsin Aging Groups. The Wisconsin Step Therapy Coalition, representing health care ... […]
- Successful Aging: Technology is looking at ways to improve the process of getting older on April 17, 2019 at 11:35 am
I recently had the opportunity to attend a conference entitled “Aging into the Future” sponsored by the St. Barnabas Senior Services (SBSS). It was designed to showcase the convergence between ... […]
- Boosting muscle stem cells to treat muscular dystrophy and aging muscles on April 17, 2019 at 2:48 am
However, these mechanisms are poorly understood. Muscle wasting occurs as part of the natural aging process, called sarcopenia, or due to genetic diseases such as muscular dystrophy. Sarcopenia ... […]
- Comparison of multi-tissue aging between human and mouse on April 17, 2019 at 2:29 am
Aging can cause multiple organ function attenuations ... There are just 8 overlapping age-related DEGs among these four tissues (see Table S5). As the studying process of human brain, the results of ... […]
- Anti-Aging Ingredient Market Forecast Highlights Revenue Share Analysis Across Prime Geographies During the Forecast Period 2018 to 2028 on April 17, 2019 at 1:19 am
These ingredients do not stop the process of aging but can reduce its effects. These ingredients are nutrition laden, and apart from reducing aging signs, they also benefit the body by keeping it fit ... […]
- Keto diet - for the military, aging and epilepsy on April 16, 2019 at 10:02 pm
This is important for the aging process explain the researchers. When a person follows the keto diet there is increased production of βOHB. This may play a role in reversing the effects of aging and ... […]
- Aging Doesn’t Have to Be Scary (Except if You’re in Silicon Valley) on April 16, 2019 at 9:59 pm
Technology will be a tremendous boon as we all age, but not to ‘solve it.’ Aging doesn’t need to be solved. It’s a natural, powerful, lifelong process and unites us all. […]
- Anti-Aging Drug Reduces Risk Of Age Related Diseases on April 16, 2019 at 5:40 pm
... drugs would work to wash away these dysfunctional cells to be replaced by newer cells which can help to slow down the aging process. “Most people don’t want to live to 130 and feel like they’re ... […]
- Anti-Aging Discovery Could Lead to Restorative Skin Treatments on April 15, 2019 at 1:31 pm
The study suggests that the stem cells that divide vertically do so because they are damaged through regular aging and the normal cell turnover process, as well as exposure to UV light or other ... […]
- Millennials seek to slow the aging process on April 8, 2019 at 2:51 pm
After her fourth child, Lisa Wilkie felt open to getting a little cosmetic work done. Feeling the toll having children had taken on her body, she made an appointment to discuss breast augmentation. ... […]
via Bing News