New therapeutic molecules developed at Toronto’s Centre for Addiction and Mental Health (CAMH) show promise in reversing the memory loss linked to depression and aging.
These molecules not only rapidly improve symptoms, but remarkably, also appear to renew the underlying brain impairments causing memory loss in preclinical models. These findings were presented today at the American Association for the Advancement of Science (AAAS) Annual Meeting in Washington DC.
“Currently there are no medications to treat cognitive symptoms such as memory loss that occur in depression, other mental illnesses and aging,” says Dr. Etienne Sibille, Deputy Director of the Campbell Family Mental Health Research Institute at CAMH and lead scientist on the study.
What’s unique and promising about these findings, in the face of many failures in drug development for mental illness, is that the compounds are highly targeted to activate the impaired brain receptors that are causing memory loss, he says.
It took a series of studies – the most recent appearing in January 2019 in Molecular Neuropsychiatry – to reach this stage. First, Dr. Sibille and his team identified the specific impairments to brain cell receptors in the GABA neurotransmitter system. Then they showed that these impairments likely caused mood and memory symptoms in depression and in aging.
The new small molecules were invented to bind to and activate this receptor target. The idea was that they would exert a therapeutic effect by “fixing” the impairment, resulting in an improvement in symptoms. The molecules are chemical tweaks of benzodiazepines, a class of anti-anxiety and sedative medications that also activate the GABA system, but are not highly targeted.
A single dose of these new molecules was administered in preclinical models of stress-induced memory loss. Thirty minutes later, memory performance returned to normal levels, an experiment that was reproduced more than 15 times. In another experiment involving preclinical models of aging, memory declines were rapidly reversed and performance increased to 80 per cent after administration, essentially reaching levels seen in youth or earlier stages of adulthood. This improvement lasted over two months with daily treatment.
“The aged cells regrew to appear the same as young brain cells, showing that our novel molecules can modify the brain in addition to improving symptoms,” says Dr. Sibille. He expects to start testing the molecules in clinical research in two years. “We’ve shown that our molecules enter the brain, are safe, activate the target cells and reverse the cognitive deficit of memory loss.”
If successful, the potential applications are broad. Not only is there a lack of treatment for cognitive deficits in mental illness, but the brain improvements suggest the molecules could help to prevent the memory loss at the beginning of Alzheimer’s disease, potentially delaying its onset.
The Latest on: Memory loss and depression
via Google News
The Latest on: Memory loss and depression
- The Imminent Small Business Collapseon March 22, 2020 at 9:00 am
During every other major disaster in memory—the financial crisis, 9/11, the Great Depression—these sales dropped ... They’re dealing with a sudden and catastrophic loss of income, which could extend ...
- This Physician Is Using Hormones to Treat TBI Patientson March 22, 2020 at 5:48 am
While some physicians are shy about using testosterone and other hormones to treat patients with a traumatic brain injury, that hasn't stopped one southern California physician. Studies have found ...
- How cooking became the perfect recipe for my spiraling anxietyon March 22, 2020 at 5:40 am
Counselors and therapists look at the culinary arts as a treatment for angst, depression, grief and loss. That’s particularly helpful now.
- Coronavirus in Texas: For seniors, social distancing saves lives, but not without coston March 21, 2020 at 11:46 am
Depression can lead seniors to abandon routines that keep other health troubles ... AGE of Central Texas is keeping open its daytime care centers for seniors with memory loss. Some VFW posts are ...
- Doing a puzzle, painting and playing with pets are top activities to keep your brain healthy at homeon March 19, 2020 at 5:00 pm
According to Dr Rachel M Allan, Chartered Counselling Psychologist, mindfulness practice can help to reduce stress and depression and improve mood ... often use creative mediums like painting and ...
- Belinda Nunezon March 19, 2020 at 7:59 am
I have dedicated myself over the last decade to providing efficient, empathetic, and supportive services to countless clients with various needs and circumstances from differing backgrounds and of ...
- Spotting Major Depression in the Grievingon March 17, 2020 at 5:12 am
And because the point of healing is not to forget but to carry a loved one’s memory into the future as an integral ... In the more severe cases, licensed professionals treat clinical depression with ...
- DR MICHAEL MOSLEY reveals how to have a restful slumber - and fight off viruseson March 13, 2020 at 6:11 pm
While studies have shown that not getting enough sleep can increase the risk of depression, memory loss and obesity, they have also identified many benefits which follow a good night’s sleep. These ...
- Sadness vs. Depression as a Response to Agingon February 28, 2020 at 12:04 pm
loss of memory; loss of hearing; loss of eyesight; and sometimes loss of financial stability. So it is not surprising that aging and depression often go together. Feeling sad about these losses ...
- 7 Natural Ways To Overcome Depression, Anxiety And Memory Losson February 25, 2020 at 11:28 pm
Here are 7 natural remedies to get rid of depression, that will help you live a happy life. Being depressed can make you feel helpless. Therapy and medications can help you to fight it.
via Bing News