Vaccines have saved millions of lives, but nobody likes getting a shot. That’s why scientists are trying to develop oral vaccines for infectious diseases.
But to be effective, the vaccine must survive digestion and reach immune cells within the intestinal wall. Now, researchers reporting in the ACS journal Nano Letters have developed oral vaccines powered by micromotors that target the mucus layer of the intestine.
In addition to avoiding needles, oral vaccines can generate a broader immune response by stimulating immune cells within the mucus layer of the intestine to produce a special class of antibody called immunoglobulin A (IgA). Joseph Wang, Liangfang Zhang and colleagues wondered if they could use magnesium particles as tiny motors to deliver an oral vaccine against the bacterial pathogen Staphylococcus aureus. When coated over most of their surfaces with titanium dioxide, magnesium microparticles use water as fuel to generate hydrogen bubbles that power their propulsion.
To develop the oral vaccine, the researchers coated magnesium micromotors with red blood cell membranes that displayed the Staphylococcal ?-toxin, along with a layer of chitosan to help them stick to the intestinal mucus. Then, they added an enteric coating that protects drugs from the acidic conditions of the stomach. When given orally to mice, the micromotors safely passed through the stomach, and then the enteric coating dissolved, activating the motors. Imaging of mice that had been given the vaccine showed that the micromotors accumulated in the intestinal wall much better than non-motorized particles. The micromotors also stimulated the production of about ten times more IgA antibodies against the Staphylococcal ?-toxin than the static particles.
Learn more: Micromotors deliver oral vaccines
The Latest on: Oral vaccines
via Google News
The Latest on: Oral vaccines
- Timing is Everything for Newborn Calf Vaccines and Colostrum on February 8, 2019 at 3:26 pm
It all starts on Day 1.” Boe also stresses the importance of delivering every newborn a dose of oral vaccine containing modified live strains of rotavirus and coronavirus. But the timing interval betw... […]
- Oral Vaccines Powered by Micromotors Developed on February 7, 2019 at 12:32 pm
Oral vaccines powered by micromotors that target the mucus layer of the intestine have been developed by scientists. The findings are published in ACS journal Nano Letters. Vaccines have saved million... […]
- Soligenix Announces Publication Demonstrating Thermostabilization of an Ebola Subunit Vaccine Candidate on February 7, 2019 at 4:00 am
For vaccines that are intended for long-term stockpiling ... dusquetide (SGX942) for the treatment of oral mucositis in head and neck cancer, and proprietary formulations of oral beclomethasone 17,21- ... […]
- Oral Vaccines Market will surge at 7.1% CAGR up to 2025: QY Research, Inc. on February 7, 2019 at 3:21 am
QY Research has come up with a newly published report on global Oral Vaccines market in its database that provides an in-depth analysis of the key market insights, its future trends, and developments, ... […]
- HPV affects many in NJ but vaccine for kids could stop it on February 6, 2019 at 7:28 pm
For men, oral and pharyngeal cancer. But a series of vaccinations is available, aimed to prevent the types of HPV associated with cancers. The HPV vaccine is one of four recommended for adolescent ... […]
- Self-Propelling Pills Could Mean The End of Needle Vaccines on February 6, 2019 at 1:25 pm
The problem with oral vaccines — ones that take pill form — is that they can sometimes get broken down by stomach acid or get spit right back up by a child. That’s why researchers are ... […]
- Micromotors may deliver oral vaccines on February 6, 2019 at 9:04 am
Vaccines have saved millions of lives, but administering injections can be difficult and painful in human medical or veterinary settings. Therefore, researchers are trying to develop oral vaccines for ... […]
- Micromotors deliver oral vaccines on February 6, 2019 at 6:01 am
Vaccines have saved millions of lives, but nobody likes getting a shot. That's why scientists are trying to develop oral vaccines for infectious diseases. But to be effective, the vaccine must ... […]
- Global Oral Vaccines Market | Recent Trends, Growth Factors and Business Development Strategy 2019-2028 on February 4, 2019 at 9:48 pm
Feb 05, 2019 (WiredRelease via COMTEX) -- Market.us add the Latest report on “Global Oral Vaccines Market By Type (Rotavirus Vaccine, Cholera Vaccine, and Polio Vaccine), By Application (Infant, Child... […]
- Research delivers insight into the Oral Vaccine market growth by 2018-2025 on January 31, 2019 at 4:00 pm
Submitted by Tina WhaTech Premium. Global Oral Vaccine market report is first of its kind research report that covers the overview, summary, market dynamics, competitive analysis, and leading player’s ... […]
via Bing News