Researchers at Western University and Lawson Health Research Institute are using tobacco plants as ‘green bioreactors’ to produce an anti-inflammatory protein with powerful therapeutic potential.
The plants are being used to produce large quantities of a human protein called Interleukin 37, or IL-37. The protein is naturally produced in the human kidney in very small quantities and has powerful anti-inflammatory and immune-suppressing properties, providing potential for treating a number of inflammatory and autoimmune disorders like type 2 diabetes, stroke, dementia and arthritis.
“This protein is a master regulator of inflammation in the body, and has been shown in pre-clinical models to be effective in treating a whole host of diseases,” said Dr. Tony Jevnikar, Professor at Western’s Schulich School of Medicine & Dentistry and Scientist at Lawson. “The human kidney produces IL-37, but not nearly enough to get us out of an inflammation injury.”
And while showing promise in animal models, IL-37’s use clinically has been limited because of the inability to produce it in large quantities at a price that is feasible clinically. Currently, it can be made in very small amounts using the bacteria E. coli, but at a very high cost.
That’s where the tobacco plants come in.
This work is the first of its kind to demonstrate that this functional human protein can be produced in plant cells. “The plants offer the potential to produce pharmaceuticals in a way that is much more affordable than current methods,” said Shengwu Ma, PhD, Adjunct Professor in the Department of Biology at Western and Scientist at Lawson. “Tobacco is high-yield, and we can temporarily transform the plant so that we can begin making the protein of interest within two weeks.”
The researchers have shown in a recent study published in the journal Plant Cell Reports, that the protein can be extracted and quantified from the plant cells in a way that maintains its function. Now that they’ve shown they can produce the protein in tobacco, it can be translated to other plants, like potatoes.
Dr. Jevnikar is investigating the effect that IL-37 has for preventing organ injury during transplantation. When an organ is removed for transplantation and then transferred to a recipient, inflammation occurs when the blood flow is restored to the organ. He and his team believe IL-37 provides a way to prevent that injury.
“I hope that this work will impact a change in how people view plants and hopefully this approach will be a way to provide treatments to patients that are effective and affordable,” Dr. Jevnikar said.
The Latest on: Green bioreactors
via Google News
The Latest on: Green bioreactors
- Worldwide Bioreactors Market Analysis and Forecasts 2020-2027 with COVID-19 Industry Impact Analysison June 11, 2020 at 6:10 am
DUBLIN, June 11, 2020 /PRNewswire/ -- The "Bioreactors Market Forecast to 2027 - COVID-19 Impact and Global Analysis by Cell; Molecule; Technology; End User, and Geography" report has been added ...
- Fujifilm Investing $928M In Denmark Expansionon June 10, 2020 at 3:26 pm
The investment in FUJIFILM Diosynth Biotechnologies will expand production lines for bulk drug substance with the addition of a further six mammalian cell bioreactors, bringing the total to 12 x ...
- How Ancient Enzymes Can Contribute to Greener Chemistryon June 10, 2020 at 11:13 am
The method can be used to develop sustainable solutions within biotechnology, such as for enzyme bioreactors or to chemically degrade ... new enzymes that can catalyze unusual reactions for green ...
- Ancient enzymes can contribute to greener chemistryon June 9, 2020 at 5:00 pm
The method can be used to develop sustainable solutions within biotechnology, such as for enzyme bioreactors or to chemically ... catalyse unusual reactions for green chemistry, sustainable ...
- Paris as a Green and Sustainable Future City Is Even More Beautifulon June 9, 2020 at 6:30 am
Architectural progress can sometimes meet opposition when a city's iconic sights and historic look is challenged, but architects Vincent Callebaut's vision of a green, sustainable Paris is so ...
- Sequence-based engineering of dynamic functions of micrometer-sized DNA dropletson June 3, 2020 at 11:18 am
In polymer chemistry and soft matter physics, LLPS has been studied to elucidate the underlying mechanisms of phase separation (1–3) and to construct cell-like structures (4) or bioreactors ... and ...
- Algae’s energy potential bloomson June 2, 2020 at 5:00 pm
Val Smith, professor of ecology and evolutionary biology at Kansas University, and Judy Regnier, plant manager at the Lawrence Wastewater Treatment Plant, survey bioreactors on Thursday.
- Microbial cyborgs: Bacteria supplying poweron May 25, 2020 at 3:35 am
The bacteria (green) are embedded in a composite made of carbon nanotubes ... applications of such materials might even extend beyond microbial biosensors, bioreactors, and fuel cell systems,” ...
- EnerDynamic - Announces Update on the Co-Operation Agreement with Solar Grants Biotechnology Inc.on May 20, 2020 at 4:47 am
NIAGARA FALLS and LONDON, ON / ACCESSWIRE / May 20, 2020 / EnerDynamic Hybrid Technologies Corp. (TSXV:EHT) ("EHT") is pleased to announce an update on the co-operation agreement with Solar Grants ...
- EnerDynamic - Announces Update on the Co-Operation Agreement with Solar Grants Biotechnology Inc.on May 19, 2020 at 5:00 pm
SGB has recently summited a proposal to the Federal Government of Canada for funding which states: "This project aims to optimize the production of human recombinant proteins using "green bioreactors" ...
via Bing News