A new technique using patients’ own modified cells to treat Crohn’s disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.
Researchers at the NIHR Guy’s and St Thomas’ Biomedical Research Centre (BRC) developed the technique by studying white blood cells taken from patients who have Crohn’s disease, and comparing them to cells of healthy people. Their findings allowed cell therapy specialists in the BRC to develop a treatment involving taking patients’ cells, and growing them in a special culture so that they behave more like cells from healthy people.
The research, published in the journal Gastroenterology, shows that this technique is effective in human cells, meaning it is ready for use in a clinical trial. The proposed Tribute Trial will test whether the treatment is safe and effective for treating Crohn’s disease.
Crohn’s disease is a lifelong condition in which parts of the digestive system become severely inflamed, causing a range of symptoms such as diarrhoea, stomach aches, tiredness and weight loss. Its causes are unknown, but the immune system is known to play a part. The often debilitating condition is estimated to affect around 620,000 people in the UK.
Professor Graham Lord, previously Director of our BRC, led the research. He recently took up a role as Vice-President and Dean of the Faculty of Biology, Medicine and Health at the University of Manchester. He said:
“This is the next frontier in cell therapy, as we’re going beyond treating the symptoms of Crohn’s disease, and trying to reset the immune system to address the condition.
“It’s a real home-grown treatment in the sense that we started with observing cells and tissues donated by patients at Guy’s and St Thomas’, have developed a treatment, and are now starting to undertake trials, all at the Trust. It shows how central patients are to research, helping to create a treatment that might help thousands more people.”
Rachel Sawyer, a communications manager who is 50 and lives in Anerley in south east London, was diagnosed with Crohn’s disease in 2000 and treated at Guy’s and St Thomas’. Although her condition is now under control, she supports other people who have Crohn’s and runs the Twitter account @Bottomline_IBD.
She said: “One of the worst things for me was the unpredictability, particularly around needing the toilet in a hurry. Having Crohn’s completely re-routes your daily life and makes it hard to do the normal things most of us take for granted like going out socially or taking public transport. Even now, the fear of it is never really far from my mind.
“Another difficult thing is the stigma associated with bowel disease. It’s difficult to talk and be open about it, even with family and friends. I found life very isolating and challenging at times – and that’s something so many people with Crohn’s experience, regardless of whether they were diagnosed years ago or last month. For people diagnosed young, it can impact on the formative years of their life.
“Anything that could help people with Crohn’s have the confidence to go out and get back to being the people they were destined to be would be a game-changer.”
The researchers found that specialised white blood cells called regulatory T cells from Crohn’s patients produced less of a gut-specific protein called integrin ?4?7 than regulatory T cells from healthy people. Working with the specialists at the NIHR Guy’s and St Thomas’ BRC’s Advanced Therapies Manufacturing Platform, they developed a cell therapy technique based on these findings.
This technique involves developing cells from the Crohn’s disease patients with a molecule called RAR568, which restores healthy levels of integrin ?4?7. The cells are then given back to patients by intravenous infusion.
The Latest on: Crohn’s disease
via Google News
The Latest on: Crohn’s disease
- Crohn's Disease Drugs Market 2019: Industry Demands, Industry Analysis & Forecast By 2024on October 25, 2019 at 6:21 am
Oct 25, 2019 (Heraldkeepers) -- New York, October 25, 2019: Major factors leading to the growth of the market includes higher preference for symptomatic therapeutic, better treatment of Crohn's ...
- Top stories in gastroenterology: New antibiotic effectively treats Crohn’s, fecal microbiota transplantation decreases mortalityon October 25, 2019 at 4:25 am
Phase 3 trial results indicated the oral antibiotic known as RHB-104 led to durable clinical remission in patients with Crohn’s disease, and a recent study showed that fecal microbiota transplantation ...
- What is Crohn’s disease? The symptoms, causes and remedies you need to knowon October 25, 2019 at 4:08 am
Here, we round up everything there is to know about the type of inflammatory bowel disease (IBD), including the Crohn's symptoms, causes and even some natural remedies you can try yourself at home, so ...
- "Richard helped me raise awareness of Crohn's"on October 25, 2019 at 3:13 am
He made an impact during his stint on reality show, ‘The Circle’, but perhaps the most memorable moment of Richard Madeley’s time on the show came during an emotional meeting with contestant, Georgina ...
- Crohn's Disease Market Size to Exhibit a CAGR of 3% By 2022 | Share Analysis, Future Insights and Global Crohn's Disease Therapeutics Market Trendson October 25, 2019 at 1:45 am
Crohn's Disease Market Size, Insights and Trends Analysis By Drugs (Immune System Suppressors, Antibiotics, Anti-Diarrheal, Pain Relievers, Anti-Inflammatory Drugs), Procedures (Computerized ...
- Joint Statement from the Canadian Association of Gastroenterology and Crohn's and Colitis Canadaon October 24, 2019 at 5:08 pm
The paper, entitled Joint Canadian Association of Gastroenterology and Crohn's and Colitis Canada Position Statement on Biosimilars for the Treatment of Inflammatory Bowel Disease, was co-authored by ...
- Can cannabis help with Crohn’s disease? Doctors and patients weigh inon October 24, 2019 at 11:58 am
Can cannabis help with the symptoms of Crohn’s disease? This is a popular question, with a myriad of articles claiming that cannabinoid-rich oil can bring relief—or even a cure—to those diagnosed with ...
- Rates of IBD Including Crohn’s Disease Are 3 Times Higher Than Realizedon October 21, 2019 at 5:07 pm
Researchers at Sandwell and West Birmingham hospitals NHS Trust and the University of Birmingham examined IBD cases from 2000 to find accurate data on ulcerative colitis (UC) and Crohn’s disease (CD) ...
- Could dandruff and Crohn's be connected? Researchers are lookingon October 20, 2019 at 11:34 pm
Already, these studies have uncovered striking connections between fungi and several chronic illnesses, including Crohn's disease and ulcerative colitis. As is typical in medical science, a simple ...
- You Don’t Look Sick: ‘Crohn’s is more than just lots of trips to the toilet’on October 20, 2019 at 1:34 am
This time, we’re with Rebecca Chapman, 28, who has Crohn’s disease- a bowel condition where parts of the digestive system become inflamed. It causes pain, fatigue, difficulty digesting food and ...
via Bing News