An engineered virus kills cancer cells more effectively than another virus currently used in treatments, according to Hokkaido University researchers.
Hokkaido University researchers have engineered a virus that selectively targets and kills cancer cells. The virus, called dl355, has an even stronger anticancer effect than another engineered virus currently used in clinical practice, according to a study published in the journal Oncology Reports.
Molecular oncologist Fumihiro Higashino and colleagues deleted a gene involved in viral replication, called E4orf6, from a type of adenovirus. The team previously discovered that E4orf6 stabilizes a type of mRNA called ARE-mRNAs in the infected cells enabling viral replication. ARE-mRNAs are known to be stable in stressed cells and cancer cells, but rapidly degrade in normal cells.
In laboratory tests, they found that their modified adenovirus, called dl355, replicated and increased its number significantly more in cancer cells than it did in normal cells. Higashino explains “The E4orf6-lacking virus relies on the stable ARE-mRNAs in cancer cells for its replication.”
Some viruses can be used to treat cancers, as they replicate within the cells until they burst and die. The researchers infected several types of cultured cancer cells with 100 dl355 virus particles per cell and found that nearly all the cancer cells died within seven days. In contrast, most normal cells infected with the virus did not die, even after seven days. Several cancer cell lines managed to survive low doses of dl355, but all cancer cells were killed by the virus as the dose was increased. Tumour growth was also significantly suppressed when dl355 was administered to human tumour cells grown in mice.
Finally, the team compared the anticancer effects of dl355 with another anticancer adenovirus currently used in clinical practice, called dl1520. dl355 replication was higher in all cancer cell lines tested, including cervical and lung cancer cells, and was better at killing all but one type of cancer cell, compared to dl1520. Both viruses only killed very few normal cells.
The findings suggest that dl355 has potential to be an effective anticancer treatment, the team concludes. They suggest enhancing the stabilization of ARE-mRNAs in cancer cells could even further strengthen its effect, but Professor Higashino notes that further research is required. “While we think dl355 has the potential to be an effective treatment method in dealing with many types of cancers, much more research needs to be done. When we think of a timeline, at least five more years of further research may be required, possible more, on top of clinical trials,” Professor Higashino noted.
Learn more: Engineering a cancer-fighting virus
The Latest on: Engineered virus
via Google News
The Latest on: Engineered virus
- Democrats Outline Modified Convention Amid Coronavirus Fearson June 24, 2020 at 5:20 pm
The in-person Democratic National Convention will be scaled down significantly as a result of the ongoing coronavirus pandemic, with the Milwaukee event ...
- COVID-19 in Canada: B.C.'s new virus models renew hope for Canadian travel, Atlantic Canada considers travel bubbleon June 24, 2020 at 10:43 am
As cases of COVID-19 continue to spread around the world, Canadians are concerned about their health and safety.
- China’s Virus-Safety Demand Is Latest Hurdle to Trade Dealon June 24, 2020 at 10:28 am
China trade deal has just suffered a new setback. Load Error China wants international shippers of meat and soybeans to sign a document attesting their cargoes meet safety standards to ensure they ...
- Washington to require masks as virus activity increaseson June 24, 2020 at 7:00 am
Washington state will require people to wear facial coverings in public settings beginning Friday, under a statewide public health order announced Tuesday by Gov. Jay Inslee in response to increased ...
- Oncolytic virus-derived type I interferon restricts CAR T cell therapyon June 24, 2020 at 2:34 am
Oncolytic viruses promote an inflammatory response and elicit anti-tumor immunity. Here the authors show, unexpectedly, that the oncolytic virus, VSVIFNβ, induces type I interferon responses that, ...
- China’s Virus-Safety Demand Is Latest Hurdle to Trump Trade Dealon June 23, 2020 at 8:28 pm
China trade deal has just suffered a new setback.China wants international shippers of meat and soybeans to sign a document attesting their cargoes meet safety standards to ensure they aren’t ...
- AP PHOTOS: Virus sidelines iconic Philippine jeeps, driverson June 23, 2020 at 6:47 pm
The Philippines’ iconic passenger jeepney was one of the first casualties of the country’s coronavirus outbreak, with the government imposing a tight lockdown that sidelined Manila’s “king of the road ...
- France has millions of unsold face masks after virus crisison June 13, 2020 at 2:00 am
The French praised the altruism of their prized textile and luxury goods companies for diverting their production facilities to make millions of face masks for the public during the peak of their coun ...
- Former MI6 Chief Claims Proof That Coronavirus Started 'As An Accident' In Wuhan Laboratoryon June 5, 2020 at 3:12 am
believes that the coronavirus came from a Wuhan laboratory He said there's a peer-reviewed paper supporting evidence it was man-made and engineered Dearlove said the virus was not intentionally ...
- Coronavirus pandemic started as ‘an accident’ when man-made virus leaked from China lab, ex-MI6 boss sayson June 3, 2020 at 2:47 pm
THE coronavirus pandemic "started as an accident" when the engineered virus escaped from a Chinese lab, a former MI6 chief has said. Sir Richard Dearlove says he's seen an "important" new report ...
via Bing News