A vaccine against the biggest bacterial killer on the planet is a step closer to being available with funding secured for preclinical trials.
Professor James Paton, Director of the University of Adelaide’s Research Centre for Infectious Diseases and his team have been working on a vaccine for Streptococcus pneumoniae (the pneumococcus) that could save two million lives globally a year and address the overuse of antibiotics that leads to resistance.
“The pneumococcus is the biggest bacterial killer on the planet. It’s the most common cause of pneumonia, which is responsible for about 20 per cent of deaths from all causes in children under 5 years in developing countries. Globally, the pneumococcus accounts for about two million deaths a year,” says Professor Paton.
Streptococcus pneumoniae, which is principally spread through close contact with infected but asymptomatic carriers, is the leading cause of sinus and ear infections, meningitis, sepsis and pneumonia. Ear infections are one of the most common childhood illnesses that are habitually treated with antibiotics, contributing to increasing bacterial resistance.
“Vaccinating people against Streptococcus pneumoniae would help to ameliorate the global challenge of increasing bacterial resistance to antibiotics,” says Professor Paton.
“The problem with the existing pneumococcal vaccine is that it targets the outside coat of complex carbohydrates – of which there are 98 structurally distinct types. The current vaccine costs about $150 a dose and only covers 13 types.
“What we have done is to remove this coat to expose all the surface proteins that are common to all pneumococcal types. The body mounts an immune response to these surface proteins if previously exposed or vaccinated.”
Sixteen months ago, Adelaide-based GPN Vaccines Pty Ltd was created to develop this novel “whole bacterial” vaccine (Gamma-PNTM) against Streptococcus pneumoniae. The company has already secured investment from local angel investors as well as a major grant from the National Health & Medical Research Council and a Commercialisation grant from the South Australian Government.
GPN Vaccines has now raised a further AUS$1.1 million from international and Australian-based investors that will be used for preclinical evaluation of the Gamma-PNTM vaccine. Toxicity tests will be carried out as well as the scale-up clinical grade manufacture of the vaccine in readiness for testing in a first-in-human clinical trial.
Learn more: STEP FORWARD FOR PNEUMONIA VACCINE DEVELOPMENT
The Latest on: Pneumonia
via Google News
The Latest on: Pneumonia
- James Bond actor Sir Sean Connery died from pneumonia and heart failureon November 29, 2020 at 2:15 pm
There's no ignoring the whole Sean Connery, even in death *: A man with animal magnetism and a lovely hairy chest * Sean Connery dead at ...
- Sean Connery’s cause of death listed as pneumonia, heart problems and ‘old age’on November 29, 2020 at 7:20 am
James Bond legend Sean Connery died of pneumonia, heart problems and “old age,” according to his death certificate.
- Sean Connery: James Bond star died of pneumonia and heart failure, death certificate showson November 29, 2020 at 4:18 am
Sean Connery died of pneumonia and heart failure, according to his death certificate. The legendary actor, who is best known for playing James Bond, died while sleeping at his home in the Bahamas on ...
- Sean Connery died from pneumonia and heart failureon November 29, 2020 at 3:42 am
James Bond actor Sir Sean Connery's official cause of death was listed as 'respiratory failure' brought about by pneumonia, old age and heart condition atrial fibrillation.
- Sean Connery's Cause of Death Pneumonia, Heart Failureon November 29, 2020 at 3:24 am
Sean Connery died in his sleep from pneumonia, heart failure and old age ... according to his death certificate. TMZ obtained Connery's death cert and it shows he died from respiratory failure as a ...
- To detect pneumonia in COVID-19 patients, these Temple doctors use ultrasoundon November 25, 2020 at 2:09 am
But in the emergency department at Temple University Hospital, he never carries one — despite having evaluated the lungs of hundreds of COVID-19 patients since April. Instead, he opts for ultrasound: ...
- Septic shock and pneumonia triggered by SARS-CoV-2 could be treated by radiation-activated MSCson November 23, 2020 at 5:05 pm
This study, published in the journal Cells, is based on others (all of which employed experimental models) previously conducted by researchers at the Biomedical Research Centre of the University of ...
- Global Pneumonia Vaccine Market Analysis By Size, Segments, Applications, Types, Competitors, Demographics And Forecast To 2026on November 23, 2020 at 6:04 am
Global Pneumonia VaccineMarket is growing due to growing requirements for quality inspection and surge in demand. It also provides pin-point analysis for changing competitive dynamics and provides ...
- Former Gov. Edwin Edwards back in hospital with pneumoniaon November 20, 2020 at 8:29 pm
The former governor was treated and released from the hospital Sunday but readmitted Tuesday after his wife said he became "very ill" with pneumonia in both lungs ...
- Former Louisiana governor Edwin Edwards leaves hospital after treatment for pneumoniaon November 20, 2020 at 3:19 pm
Former Louisiana Gov. Edwin Edwards was released Friday from the Baton Rouge hospital where he was being treated for pneumonia and has returned home.
via Bing News