Helping the immune system clear away old cells in aging mice helped restore youthful characteristics
If only we could keep our bodies young, healthy and energetic, even as we attain the wisdom of our years. New research at the Weizmann Institute of Science suggests this dream could be at least partly obtainable in the future. The results of this research, led by Prof. Valery Krizhanovsky and Dr. Yossi Ovadya in the Molecular Cell Biology Department, were recently published in Nature Communications.
The research began with an investigation into the way that the immune system is involved in a crucial activity: clearing away old, senescent cells that spell trouble for the body when they hang around. Senescent cells – not completely dead but suffering loss of function or irreparable damage – have been implicated in diseases of aging by promoting inflammation. The researchers used mice in which a crucial gene for this immune activity was missing. At two years (elderly, for mice), the bodies of these mice had a greater accumulation of senescent cells compared with the mice in which the gene for removing these cells was intact. The mice missing the gene suffered from chronic inflammation, and various functions in their bodies appeared to be diminished. They also looked older – and died earlier – than their normal counterparts.
The mice treated with the drug were more active and their median lifespan rose
Next, the researchers gave the mice a drug that inhibits the function of certain proteins that help the aging cells survive in their senescent state, to see if this would contribute to the removal of these cells from the body. The drugs were administered to mice whose aging was a result of the malfunctions the group had uncovered in the immune system as well as those suffering premature aging from a different genetic error. The treated mice responded exceptionally well to the drug: Their blood tests and activity tests showed improvement, and their tissues appeared to be much closer to those of young mice. The scientists counted senescent cells, finding many fewer of them remaining in the treated mice’s bodies; and when they looked for signs of inflammation, they found that this, too, was significantly lower. The mice treated with the drug were more active and their median lifespan rose.
The scientists intend to continue exploring ways to prompt the human body to remove its old senescent cells, particularly to find means of activating the immune system to do this job. That is, if future experimentation proves their theories correct, they could end up creating truly “anti-aging” therapies.
Learn more: The Immune System’s Fountain of Youth
The Latest on: Fountain of youth
via Google News
The Latest on: Fountain of youth
- Before avenging his worst loss, Canelo Alvarez must work on this part of his gameon September 19, 2022 at 6:00 am
Canelo Alvarez retained his unified super middleweight title with a unanimous decision over Gennady Golovkin in their third fight on Saturday night in Las Vegas.
- Adam Cohen: There's no fountain of youth, but a year older could mean a year betteron September 18, 2022 at 7:00 am
Don’t get me wrong. This is no fountain-of-youth tale. Their hair is still white. Mom is still in a wheelchair. My father doesn’t leave the house except to visit doctors and, occasionally, my sister ...
- In His Final Act, Adam Wainwright Found a Fountain of Youthon September 17, 2022 at 5:00 am
Since the start of the 2020 season, Adam Wainwright has resurrected his career to again become one of the game's most effective workhorses.
- How Texans defensive end Jerry Hughes has found the fountain of youth at age 34on September 16, 2022 at 11:49 am
Jerry Hughes is late. He's on the way back to NRG Stadium from an acupuncture appointment away from the team facility about an hour after practice. He's done now, but before he can sit down for an ...
- Lawmakers believe scientists are closer to discovering ‘fountain of youth’on September 15, 2022 at 2:33 pm
Federal lawmakers say discovering a “fountain of youth” to slow and perhaps end human aging is a realistic possibility.
- Want Us to Find the Fountain of Youth? Give Us Endpoints, Scientists Sayon September 15, 2022 at 2:33 pm
To advance [these medications], we need to find surrogate measures -- in other words, biomarkers." Horvath spoke at a House Science, Space, and Technology Subcommittee on Oversight and Investigations ...
- New regulatory path a must in quest for ‘fountain of youth’on September 14, 2022 at 5:00 pm
With the science on aging advancing, it’s time for the U.S. to modernize its regulatory approval path for new longevity treatments, members of a House Science, Space and Technology subcommittee were ...
- This senior dog was dumped in a shelter to die but instead found her 'fountain of youth'on September 9, 2022 at 5:07 am
This old dog’s owners asked the shelter to put her down. But the vets saw that she still had so much to give. They found her a new home where the senior pup blossomed and became ‘the queen bee of the ...
- Vera Wang, 73, sizzles in swimsuit snap: 'Fountain of youth'on September 6, 2022 at 8:05 pm
Her followers shared their well wishes and asked her for the secret to her youthful look after Vera shared some snaps to Instagram, with one user writing, "Happy birthday, gosh share your secret ...
- The fountain of youth will spout money for investorson September 5, 2022 at 5:00 pm
It's their second book (the other is Fast Forward) and Mellon reckons it outlines not just the "biggest money fountain idea that Al and I have ever seen", but also the ten or so things we can do ...
via Bing News