A team of physicists at the Institut Lumière Matière (CNRS/Université Claude Bernard Lyon 1), in collaboration with the Cancer Research Center of Lyon (CNRS/INSERM/ Université Claude Bernard Lyon 1/Centre Léon Bérard/Hospices civils de Lyon), has demonstrated the potential, for oncology, of an imaging technique based only on the physical properties of tumors. It can differentiate populations of malignant cells and monitor how effective an anticancer treatment is. These results, published in Physical Review Letters on January 8, 2019, should help in the design of new therapeutic molecules and in the personalization of treatments.
Despite a good understanding of the biology of cancer, 90% of experimental drugs fail during clinical trials. It is also increasingly suspected that the mechanical properties of tumors influence disease progression, and treatment efficacy. Although we can evaluate tumor elasticity globally, it is more difficult to measure local rigidity deep down and to see whether the core of the tumor resists the penetration of therapeutic liquids. To probe these physical properties, the researchers have used a noncontact imaging technique that does not require the use of contrast agents – therefore that does not disturb tissue function – that exploits natural infinitesimal vibrations of matter.
To recapitulate the behavior of colorectal tumors in vitro, the researchers created organoids, spheres with diameter 0.3 mm formed by the aggregation of tumor cells. They focused a red laser beam onto these objects. The infinitesimal vibrations of the sample, generated by thermal agitation, modify very slightly the color of the light beam that exits the sample. By analyzing this light, a map of the mechanical properties of the model tumors is created: the more rigid the area scanned by the laser, the faster the vibrations and, in a manner comparable to the Doppler effect (the mechanism that makes a siren sound increasingly shrill as it gets closer), the greater the color change.
From organoids composed of two cell lines with different malignancies, the researchers have shown that they could distinguish the two cell types from their mechanical properties. Such information is crucial because it may allow diagnosis from biopsy analysis to be refined and offer better assessment of tumor grade. Local variations in mechanical properties after a drug treatment have also been monitored using this technique: the center of the tumor remains rigid longer than the edge, demonstrating the treatment’s efficacy gradient. So local measurement of mechanical properties could confirm the total destruction of the tumor and help in choosing as low a treatment dose and duration as possible.
This approach allows exploring the impact of mechanical properties on the therapeutic response. It should lead to more predictive in vitro tumor models for testing new therapeutic molecules and for combined therapies, which act for example on tissue rigidity to accelerate the penetration of active molecules in the center of the tumor. It could also provide new indicators to guide clinicians in personalization of therapies.
Learn more: Physics can show us the inside of tumors
The Latest on: Personalized cancer treatment
via Google News
The Latest on: Personalized cancer treatment
- I-SPY 2 Breast Cancer Clinical Trial Coming To Wake Forest Baptist Healthon October 17, 2019 at 6:27 pm
“With this study, data is constantly being analyzed and medications are adjusted throughout the course of the trial, so each patient receives personalized treatment,” said Thomas. The data will be ...
- Recent Research Utilizing AI For Early Detection Of Breast Cancer Has Doctors Rethinking The Human Role In Diagnosison October 17, 2019 at 5:22 pm
I’ve never really thought about how important personalized medical care is until I was diagnosed ... Following 10 years of yearly mammograms, about two out of three patients who don't have cancer will ...
- 'Each person' cancer should have a personalized plan,' Genomic testing cancer treatment planon October 17, 2019 at 4:49 pm
Many new cancer treatment options have become available over the past few years. But many of these require a comprehensive genomic test first in order to determine which might be beneficial to a ...
- Newly established Precision Immunotherapy Clinic matches cancer patients to latest treatmentson October 17, 2019 at 4:13 pm
We can no longer detect cancer in him." Miller cautions that the off label use is not a proven approach and may not result in a positive response in all patients. With access to experts at the ...
- Expert Panel: Cancer Treatment Plans Should Include Tailored Exercise Prescriptionson October 17, 2019 at 10:18 am
This includes formally and systematically using custom exercise prescriptions that best meet the needs ... View and download the Exercise for Cancer Prevention and Treatment infographic. To implement ...
- Personalized BRAF inhibitor treatment: a new way to treat melanomaon October 17, 2019 at 6:00 am
Researchers from the Moffitt Cancer Centre & Research Institute found a new way to use BRAF inhibitor ... cells as part of the tumour to prevent uncontrolled growth of drug-resistant cells. The test ...
- Genomic Testing Critical for Advancing and Optimizing Cancer Careon October 16, 2019 at 12:19 pm
When conducted at the time of a cancer diagnosis, genomic testing can provide more personalized treatment planning and change the course of treatment instead of first following decades-old regimens ...
- A systems approach to clinical oncology uses deep phenotyping to deliver personalized careon October 16, 2019 at 7:32 am
and for the design of personalized treatments. Hood, L. & Friend, S. H. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat. Rev. Clin. Oncol. 8, 184–187 (2011).
- Urine test shows potential for detection, personalized treatment of bladder canceron October 16, 2019 at 5:04 am
Investigators from Georgetown University Medical Center and Fudan University in China have developed a novel noninvasive and individualized technique for the detection and treatment of bladder cancer.
- Global Personalized Cancer Vaccine Market Opportunity Clinical Innovation Trend Outlook 2026on October 15, 2019 at 2:22 am
Most of the cancer vaccines under development are focused on the treatment of deadly and highly prevalent cancers such as Melanoma, breast cancer, lung cancer, prostate cancer and Cervical Cancer.
via Bing News