In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases.
The study was published recently in Cell Reports.
The circadian clock operates within the body and its organs as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment. And, while food is known to influence clocks in peripheral tissues, it was unclear, until now, how the lack of food influences clock function and ultimately affects the body.
“We discovered fasting influences the circadian clock and fasting-driven cellular responses, which together work to achieve fasting-specific temporal gene regulation,” said lead author Paolo Sassone-Corsi, Donald Bren Professor of Biological Chemistry at UCI’s School of Medicine. “Skeletal muscle, for example, appears to be twice as responsive to fasting as the liver.”
The research was conducted using mice, which were subjected to 24-hour periods of fasting. While fasting, researchers noted the mice exhibited a reduction in oxygen consumption (VO2), respiratory exchange ratio (RER), and energy expenditure, all of which were completely abolished by refeeding, which parallels results observed in humans.
“The reorganization of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. In other words, fasting is able to essentially reprogram a variety of cellular responses. Therefore, optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefitting health and protecting against aging-associated diseases.”
This study opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans.
Sassone-Corsi first showed the circadian rhythm-metabolism link some 10 years ago, identifying the metabolic pathways through which circadian proteins sense energy levels in cells.
The Latest on: Fasting
via Google News
The Latest on: Fasting
- Stars Who've Found Success with Intermittent Fastingon January 22, 2020 at 5:43 pm
The surprising fact, however, aligns with Dorsey’s daily practice of intermittent fasting, which he opened up about on the Fitness: Diet, Fat Loss and Performance podcast. During the interview, Dorsey ...
- Christian Association of Nigeria calls for 3 days of prayer, fasting after Boko Haram executes pastoron January 22, 2020 at 11:23 am
The Christian Association of Nigeria is demanding answers from the Nigerian government as the interdenominational body is calling for three days of prayer and fasting after the execution of one of its ...
- Intermittent Fasting 101 with Dr. Ian Smithon January 21, 2020 at 10:37 am
Still a very popular tool for weight loss, intermittent fasting does have a few do's and don'ts. Dr. Ian Smith, author of "Clean and Lean" says if you're already using IF, a few tweaks could lead to ...
- Intermittent fasting for weight loss: 5 benefits and 5 ways to get startedon January 21, 2020 at 5:47 am
Intermittent fasting — the practice of strictly limiting the hours when one eats — keeps getting more popular. For years, obesity scientists and physicians collected data to understand the benefits of ...
- What to know about 3 trendy diets for 2020: Prebiotics, plant-based and intermittent fastingon January 18, 2020 at 11:23 am
MORE: Why easing into your New Year’s resolutions may be better than going cold turkey: 3 strategies to stay on track 1. Intermittent fasting Intermittent fasting is nothing new, but it is emerging as ...
- What is dry fasting?on January 18, 2020 at 2:18 am
Intermittent fasting is a very popular way of dieting. The fad has grown, and more and more people want to try it to lose weight. However, dry fasting is when someone fasts without drinking lots of ...
- What Are The Side Effects of Intermittent Fasting?on January 17, 2020 at 7:43 am
You might have heard about intermittent fasting everywhere in 2019, but it's still not very well understood. The possible health benefits of intermittent fasting, which restricts eating to certain ...
- The Easiest Way to Start Fasting Is to Stop Eating Breakfaston January 14, 2020 at 5:40 am
“For one, skipping breakfast extends your nighttime fast and compresses the window of opportunity to overeat,” says Carolyn Williams, a James Beard award-winning dietician, who served as a consulting ...
- Does intermittent fasting work? Research doesn't have a definite answer for its long-term effectson January 13, 2020 at 1:41 pm
While intermittent fasting can help some people lose weight, it isn't recommended for everyone. Here's how to know if it's right for you.
- 7 Intermittent Fasting Benefits That Aren’t Weight Losson January 13, 2020 at 12:07 pm
Most people try fasting with one goal in mind: losing weight. But science has also discovered health benefits linked to whole-day, alternate-day, and time-restricted fasting, says Carolyn Williams, Ph ...
via Bing News