Scientists have created the most comprehensive method yet to predict a woman’s risk of breast cancer, according to a study led by researchers at the University of Cambridge. The study, funded by Cancer Research, is published today in Genetics in Medicine.
It could be a game changer for breast cancer because now we can identify large numbers of women with different levels of risk – not just women who are at high risk
They have a developed a way of calculating the risk of developing the disease by combining information on family history and genetics with other factors such as weight, age at menopause, alcohol consumption and use of hormone replacement therapy.
Although individually some of these things have a small impact on the likelihood of developing the disease, researchers found that by considering all of them at once, plus family history and genetics, they can identify groups of women who have different risks of developing breast cancer.
Importantly, for the first time, researchers have taken into account more than 300 genetic indicators for breast cancer. This makes calculating the risk much more precise than ever before.
From this, the researchers have created an online calculator for GPs to use in their surgeries.
Some GPs, practice nurses and genetic counsellors are testing this tool before it is considered for wider use. Doctors are prompted to answer a series of online questions about their patient including their medical and family history, whether they have any known genetic alterations linked to cancer, their weight and whether they drink alcohol.
In the future, information like this could help to tailor breast cancer screening depending on an individual’s risk. For example, it could help determine what age they are first invited for breast screening or how regularly they are invited to receive it.
The risk calculation could also help people to make decisions about preventative therapy – such as identifying women at high risk who may benefit from taking the drug tamoxifen – as well as encouraging women to think about the ways they could reduce the risk themselves, for example trying to keep a healthy weight.
Professor Antonis Antoniou, lead author at the Department of Public Health and Primary Care, University of Cambridge, said: “This is the first time that anyone has combined so many elements into one breast cancer prediction tool. It could be a game changer for breast cancer because now we can identify large numbers of women with different levels of risk – not just women who are at high risk.
“This should help doctors to tailor the care they provide depending on their patients’ level of risk. For example, some women may need additional appointments with their doctor to discuss screening or prevention options and others may just need advice on their lifestyle and diet.
“We hope this means more people can be diagnosed early and survive their disease for longer, but more research and trials are needed before we will fully understand how this could be used.”
Breast cancer is the most common cancer in the UK. Nearly 55,000 women are diagnosed with the disease each year. But a large proportion of breast cancer cases occur in people who are at an increased risk. Cancer Research UK has helped to double breast cancer survival over the last 40 years.
Dr Richard Roope, Cancer Research UK’s GP expert, said: “Research like this is hugely exciting because in the future it will enable us to offer much more tailored care which will benefit patients and make best use of the services that we have available.
“Although having an increased risk of breast cancer means a woman is more likely to develop the disease – it’s by no means a certainty. A woman at high risk may never get breast cancer just as a woman at low risk still could. But any woman with concerns should speak to her GP to discuss the options.”
The Latest on: Breast cancer
via Google News
The Latest on: Breast cancer
- New Boutique for Women Battling Breast Cancer on February 7, 2019 at 2:05 pm
LEHIGHTON, Pa. — A breast cancer survivor from Carbon County is hoping her new store will help other women battling the disease feel beautiful in their own skin. A new store in Lehighton called ... […]
- FDA warns of rare cancer linked to breast implants on February 7, 2019 at 1:26 pm
Federal health officials warn doctors and other health professionals to be on the lookout for a rare cancer linked to breast implants. In a statement released Wednesday, the Food and Drug Administrati... […]
- Physician diagnosed with breast cancer uses her personal experience to help find a cure on February 7, 2019 at 12:08 pm
A local physician who was diagnosed with breast cancer has transformed her personal experience into a supportive group for others fighting a similar battle. Andi Sharp is used to taking care of other ... […]
- FDA alerts more doctors of rare cancer with breast implants on February 7, 2019 at 11:16 am
U.S. health officials say doctors should be on the lookout for a rare cancer linked to breast implants after receiving more reports of the disease. The Food and Drug Administration sent a letter ... […]
- FDA Warns Doctors to Look Out for Rare Cancer Linked to Breast Implants on February 7, 2019 at 10:51 am
(WASHINGTON) — U.S. health officials say doctors should be on the lookout for a rare cancer linked to breast implants after receiving more reports of the disease. The Food and Drug ... […]
- Cancer Linked to Surface of Breast Implants on February 7, 2019 at 8:26 am
THURSDAY, Feb. 7, 2019 (HealthDay News) -- There's been an increase in the number of U.S. women diagnosed with a deadly cancer caused by textured breast implants, the U.S. Food and Drug Administration ... […]
- More Women Reported to Have Rare Cancer Linked to Breast Implants on February 7, 2019 at 5:11 am
More cases of a rare cancer linked to breast implants have been reported in the U.S., according to the Food and Drug Administration (FDA). This week, the FDA announced that it had received a total of ... […]
- How Surviving Breast Cancer Inspired Sandra Lee to Make it Easier for Women to Get Mammograms on February 6, 2019 at 11:10 am
Sometimes the future of cancer care comes not from scientists in labs, but from people who have been affected by the disease. That’s the case with Sandra Lee, the television star, cookbook author, and ... […]
- Combo of diabetes, leukemia drugs may fight breast cancer on February 6, 2019 at 6:37 am
Feb. 6 (UPI) --A combination of popular diabetes and immunotherapy drugs can kill breast cancer, a new study says. A mix of the diabetes drug metformin and leukemia drug venetoclax were both able to d... […]
- Combination treatment, diabetes drug and immunotherapy, may help to fight breast cancer on February 6, 2019 at 6:36 am
Researchers in Finland have discovered a drug combination that collaborates with the cancer cell oncoprotein MYC, which, in large quantities, causes self-destruction of the cancer cells. […]
via Bing News