Salk research focuses on the development of compounds that may protect against the diseases of aging, such as Alzheimer’s
Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New Salk research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.
“The argument for geroprotectors is that if one can extend the lifespan of model organisms, such as mice, and translate this effect to humans, then you should be able to slow down the appearance of many diseases that are associated with aging, such as Alzheimer’s, Parkinson’s, cancer and overall frailty,” says first author Dave Schubert, Salk professor and head of Salk’s Cellular Neurobiology Laboratory.
The study, which appeared in the journal Trends in Pharmacological Sciences, on November 13, 2018, was conducted in collaboration with Salk Senior Staff Scientist Pamela Maher, whose lab is in the Cellular Neurobiology department and who is the study’s senior author.
The team started with two chemicals found in plants that have demonstrated medicinal properties: fisetin, a natural product derived from fruits and vegetables, and curcumin, from the curry spice turmeric. From these, the team synthesized three AD drug candidates based upon their ability to protect neurons from multiple toxicities associated with the aging brain. The lab showed that these three synthetic candidates (known as CMS121, CAD31 and J147), as well as fisetin and curcumin, reduced the molecular markers of aging, as well as dementia, and extended the median lifespan of mice or flies.
Importantly, the group demonstrated that the molecular pathways engaged by these AD drug candidates are the same as two other well-researched synthetic compounds that are known to extend the lifespan of many animals. For this reason, and based on the results of their previous studies, the team says fisetin, curcumin and the three AD drug candidates all meet the definition of being geroneuroprotectors.
The group is now focusing on getting two GNPs into human clinical trials. The fisetin derivative, CMS121, is currently in the animal toxicology studies required for FDA approval to start clinical trials. The curcumin derivative, J147, is under FDA review for allowance to start clinical trials for AD early next year. The group plans to incorporate biochemical markers for aging into the clinical trials to assay for potential geroprotective effects.
“Since we found that the natural products curcumin and fisetin are also GNPs and commercially available as supplements, they could provide some therapeutic benefits right now,” says Maher.
Other studies in the lab are determining whether these compounds have effects on organs outside of the brain. “If these drugs have benefits for other body systems, such as maintaining kidney function and overall muscle health, they could be used in additional ways to treat or prevent the diseases of aging,” Schubert says.
The investigators say that the discovery of these AD drug candidates validates the drug discovery model they have developed as a plausible method for identifying additional GNP compounds that will help promote healthy aging. This could greatly accelerate the pipeline for drugs to treat the diseases of aging for which there are currently no cures.
The Latest on: Anti-aging
via Google News
The Latest on: Anti-aging
- People claim this $18 anti-aging moisturizer on Amazon delivers ‘fast results’on May 10, 2020 at 6:09 am
With over 4,900 ratings on Amazon, Neutrogena's Rapid Wrinkle Repair Cream can help tackle fine lines and wrinkles quickly.
- Thousands of Shoppers Say This Anti-Aging Face Cream Has Transformed Their Skinon May 9, 2020 at 5:01 pm
The Ole Henriksen C-Rush Brightening Gel Cream has a near-perfect customer rating from thousands of shoppers who say the product has transformed their skin.
- 9 best anti-aging moisturizers, according to skincare expertson May 7, 2020 at 4:40 am
While wrinkles, age spots, other charming characteristics of growing older are nothing shameful, most of us want to take a certain amount of care to prevent the worst of them from popping up ...
- This Anti-Aging Serum Makes My Skin So Flawless, It's Like a Filter in Real Lifeon May 6, 2020 at 2:37 pm
Since I started using Babor’s Perfect Glow Ampoule Concentrates, my skin has turned glowier than ever — and it’s my secret weapon for perfect selfies.
- Argireline Is the Anti-Aging Skincare Ingredient You Didn’t Know You Neededon May 5, 2020 at 2:18 pm
Watch the video to find out more about the anti-aging ingredient. The Washington Post Like us on Facebook to see similar stories Please give an overall site rating: ...
- Amazon’s best-selling anti-aging cream costs only $9: ‘I am hooked for life’on May 5, 2020 at 10:40 am
Putting together a new skincare routine can be costly, especially when you’re trying to include more anti-aging products. From serums to moisturizers to anti-aging creams, it can be a little ...
- RealSelf Report: 62% of Americans Use Anti-Aging Products Daily, Only 11% Wear Sunscreen Dailyon May 4, 2020 at 5:00 am
PRNewswire/ -- A new survey1 from RealSelf, the go-to destination for making cosmetic treatment decisions and connecting with doctors, reveals 62% ...
- Anti-aging Products Market Research Report includes Development Trends, Key Manufacturers and Competitive Analysis to 2026on May 4, 2020 at 12:35 am
The key purpose of this “Anti-aging Products Market” Size report 2020 is to deliver a definite and strategic analysis ...
- Anti-Aging Drugs Market From 2020-2029: Regions, End-user and Application| Allergan, Johnson and Johnson, Nu Skinon May 3, 2020 at 11:56 pm
MarketResearch.Biz published a new industry research report “Anti-Aging Drugs Market in its database. This is a latest report, including the present COVID-19 effect on the market. The global ...
via Bing News