Metabolic brain changes can be identified earlier leading to timely diagnosis and intervention.
Artificial intelligence (AI) improves the ability of brain imaging to predict Alzheimer’s disease (AD), according to a study published in Radiology.
While timely diagnosis of AD is extremely important,early diagnosis has proven to be challenging. Research has linked the disease process to changes in metabolism, as shown by glucose uptake in certain regions of the brain, but these changes can be difficult to recognize.
“Differences in the pattern of glucose uptake in the brain are very subtle and diffuse,” said study co-author Jae Ho Sohn, MD, from the Radiology & Biomedical Imaging Department at the University of California in San Francisco (UCSF). “People are good at finding specific biomarkers of disease, but metabolic changes represent a more global and subtle process.”
The study’s senior author, Benjamin Franc, MD, from UCSF, approached Dr. Sohn and University of California, Berkeley, undergraduate student Yiming Ding through the Big Data in Radiology (BDRAD) research group, a multidisciplinary team of physicians and engineers focusing on radiological data science. Dr. Franc was interested in applying deep learning (DL) to find changes in brain metabolism predictive of AD.
The researchers trained the DL algorithm using an 18-F-fluorodeoxyglucose PET (FDG-PET) scan.
The researchers had access to data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a major multi-site study focused on clinical trials to improve prevention and treatment of this disease. The ADNI dataset included more than 2,100 FDG-PET brain images from 1,002 patients. Researchers trained the DL algorithm on 90 percent of the dataset and then tested it on the remaining 10 percent of the dataset.
Finally, the researchers tested the algorithm on an independent set of 40 imaging exams from 40 patients that it had never studied. The algorithm achieved 100 percent sensitivity at detecting the disease an average of more than six years prior to the final diagnosis.
“We were very pleased with the algorithm’s performance,” Dr. Sohn said. “It was able to predict every single case that advanced to Alzheimer’s disease.”
Algorithm Could Aid Radiologists
Although he cautioned that their independent test set was small and needs further validation with a larger multi-institutional prospective study, Dr. Sohn said that the algorithm could be a useful tool to complement the work of radiologists — especially in conjunction with other biochemical and imaging tests — in providing an opportunity for early therapeutic intervention.
“If we diagnose Alzheimer’s disease when all the symptoms have manifested, the brain volume loss is so significant that it’s too late to intervene,” he said. “If we can detect it earlier, that’s an opportunity for investigators to potentially find better ways to slow down or even halt the disease process.”
Future research directions include training the DL algorithm to look for patterns associated with the accumulation of beta-amyloid and tau proteins, abnormal protein clumps and tangles in the brain that are markers specific to AD.
Learn more: AI Predicts Alzheimers Years Before Diagnosis
The Latest on: Artificial intelligence diagnostics
via Google News
The Latest on: Artificial intelligence diagnostics
- Let’s Evaluate the benefits of AI(Artificial Intelligence)on February 1, 2020 at 4:02 am
AI(Artificial Intelligence)-Building blocks and Key Elements AI has the following core technologies ... Health and life sciences: Processing data from past case notes, biomedical imaging and health ...
- Microsoft launches $40 million artificial intelligence initiative to advance global health researchon January 31, 2020 at 3:26 pm
will help advance global health initiatives, with two cash grants going to medical research at Seattle -based organizations. As part of the tech giant's $165 million AI for Good initiative, this new ...
- Beauty care pioneers self-service AI, AR technologyon January 31, 2020 at 7:53 am
Artificial intelligence and augmented reality are still in the early stages of adoption ... The ColorView will also have a hair texture diagnostic feature, Johnson said. During the CES show, ...
- Top doctors 'undertest' patients to demonstrate diagnostic prowess to peers, study findson January 31, 2020 at 6:39 am
These "high-type" experts engage in "undertesting" despite an increase in diagnostic techniques, including artificial intelligence tools that can assess patient condition more accurately than past ...
- UPDATE: Desert Medical Imaging, ProScan Imaging & Chico Breast Care Center Join Forces with HALO Diagnostics (HALO Dx)on January 30, 2020 at 3:41 pm
/PRNewswire/ -- HALO Dx, Inc., a rapid growth technology company headquartered in Silicon Valley, has brought together top technology experts with ...
- Top Doctors Limit Number of Tests They Order for Patients to Signal Level of Diagnostic Prowess to Peers, Study Sayson January 28, 2020 at 4:54 am
These "high-type experts" engage in "undertesting" despite an increase in diagnostic techniques, including artificial intelligence tools that can assess patient condition more accurately than past ...
- Artificial Intelligence to Make Significant Transformation to Medical Technology in 2020 and Beyondon January 27, 2020 at 4:15 pm
Artificial Intelligence has been in development for decades already; however, it is only in last couple of years that we saw significant improvements, and what else can benefit from this technological ...
- Desert Medical Imaging, Open System Imaging, MD Imaging & Chico Breast Care Center Join Forces with HALO Diagnostics (HALO Dx)on January 27, 2020 at 3:39 pm
Jan. 27, 2020 /PRNewswire/ -- HALO Diagnostics (HALO Dx), a technology ... HALO Dx will leverage artificial intelligence and machine learning solutions to become one of the top radiogenomics ...
- Artificial Intelligence Market Analysis By Industry Size, Share, Key Drivers, Growth Factors, Demands, Manufacturers and 2026 Forecaston January 27, 2020 at 12:32 am
Artificial Intelligence Market top players include Alphabet (Google Inc.), Apple Inc., Baidu, IBM Corporation, IPsoft, Microsoft Corporation, MicroStrategy, Inc, NVIDIA Qlik Technologies Inc, Verint ...
via Bing News