Cedars-Sinai Discovery May Aid Doctors in Diagnosing At-risk Patients Before Symptoms Appear
A team led by a Cedars-Sinai physician-scientist has discovered a biomarker—a protein found in the blood—for the most common type of heart failure, a new study published today in JAMA Cardiology shows.
Heart failure with preserved ejection fraction (HFpEF) affects more than 6.5 million Americans each year. And now, thanks to the discovery of the first-ever biomarker for HFpEF, a simple blood test can reveal whether a patient’s heart is not making enough of an important protein. If the protein levels are decreased, the biomarker signal increases and physicians will be able to diagnose heart failure sooner, prescribe corrective medicines and prevent further disease progression.
“By the time heart failure symptoms develop, the critical window for corrective therapy has typically closed,” said Robin Shaw, MD, PhD, the Wasserman Endowed Chair in Cardiology and professor of Medicine at the Smidt Heart Institute at Cedars-Sinai and principal investigator on the study. “Our discovery allows us to not only diagnose the disease sooner, but also to treat patients before that critical period of early intervention for lifesaving care has closed.”
Heart failure with preserved ejection fraction is a condition where the heart can contract, but has problems relaxing—limiting the heart’s ability to fill with blood between each beat—and therefore lowers the amount of blood moving forward with each contraction. Prior to the discovery of the biomarker, clinicians had to wait for patients to have symptoms to make a diagnosis of HFpEF and had to use an echocardiogram that measured how well the heart relaxed. There was no method to gauge the health of the heart muscle before symptoms developed or determine the severity of disease once symptoms were present.
The biomarker—named cBIN1 Score, or CS for short—allows doctors to measure muscle deterioration and measure a protein that regulates the heart’s ability to both contract and relax. As the protein decreases, CS increases, serving as an indication of onset heart failure. The CS biomarker can be measured using a simple blood draw.
This discovery will allow the most at-risk patients—including older patients and patients with high blood pressure, diabetes or dyslipidemia—to be checked during an annual exam from their primary care physician. This pivotal research has the potential to impact millions of people and serve as a critical tool for preventive heart care.
Eduardo Marbán, MD, PhD, director, Smidt Heart Institute
The CS biomarker is designed to be used in an outpatient clinic setting. For patients with known HFpEF, doctors can draw a CS level and use it to both guide current care, including medication adjustments, and predict the chances of a patient being admitted to the hospital in the next 12 months.
“More broadly, this discovery will allow the most at-risk patients—including older patients and patients with high blood pressure, diabetes or dyslipidemia—to be checked during an annual exam from their primary care physician,” said Eduardo Marbán, MD, PhD, director of the Smidt Heart Institute. “This pivotal research has the potential to impact millions of people and serve as a critical tool for preventive heart care.”
Symptoms of heart failure typically appear as fatigue, fluid weight gain, leg swelling and shortness of breath. Heart failure with preserved ejection fraction is typically diagnosed in elderly people or those living with high blood pressure, diabetes, elevated cholesterol, hypertension, obesity, obstructive sleep apnea, anemia, iron deficiency or diabetes. Its prevalence is projected to rise drastically over the coming decades. Previous studies have shown that women represent the majority of patients diagnosed with the disease.
As next steps, Cedars-Sinai researchers plan on identifying specialty populations in which the CS biomarker could be useful, including sex-based differences, those who have undergone a heart transplant or valve replacement, as well as individuals with no known heart disease or risk factors.
The Latest on: Heart failure
via Google News
The Latest on: Heart failure
- Strong Women: ‘I had heart failure at 27 – so a workout for me is walking to the shops’on September 7, 2019 at 12:52 am
Simone Gomez has cholangiocarcinoma – a serious heart condition that she was born with, but didn’t realise she had until she fell seriously ill in her 20s. Now she’s on the road to recovery ...
- Study: 9/11 first responders have higher risk of heart disease, stroke and heart attackon September 6, 2019 at 7:16 pm
A new study finds that those who were first on the scene or worked for months among the ruins of the World Trade Center disaster have an increased risk of heart disease, stroke and heart attack.
- Why Amgen's Spending Billions to Buy This 1 Drug; Plus Heart Disease Has a New Enemyon September 6, 2019 at 2:22 pm
After the Federal Trade Commission (FTC) demanded Bristol-Myers Squibb (NYSE: BMY) sell its blockbuster Otezla to secure approval for its $74 billion acquisition of Celgene (NASDAQ: CELG), a ...
- First Firefighters to Arrive at World Trade Center on 9/11 Have a Far Higher Risk of Heart Diseaseon September 6, 2019 at 9:01 am
A study of almost 10,000 firefighters who worked at the World Trade Center on September 11 has found those exposed to the dust which emerged from the destroyed buildings were more likely to develop ...
- Despite Heart Failure, This Man Maintains His Active Lifestyleon September 6, 2019 at 5:07 am
Today’s Fitness Friday episode includes an interview with David Van Deusen, who will talk with us about staying active despite living with heart disease. He has a fascinating story to tell our Not Old ...
- Occlutech AFR Heart Failure Device Obtains CE Mark Approvalon September 6, 2019 at 3:12 am
SCHAFFHAUSEN, Switzerland, Sept. 6, 2019 /PRNewswire/ -- Occlutech AG announced today that its atrial flow regulator, the Occlutech AFR device, has obtained CE mark approval clearing it for sales ...
- 9/11 first responders have higher risk of heart disease: studyon September 6, 2019 at 1:15 am
Firefighters who arrived immediately or spent more time at Ground Zero after the 9/11 attacks have a higher risk of developing heart disease, a new federally funded study reveals. The analysis ...
- Being vegetarian or vegan could 'lower heart disease risk but increase chance of stroke'on September 5, 2019 at 11:02 am
A study, by the University of Oxford, found 20% higher rates of stroke in vegetarians and vegans, than in meat eaters: the equivalent to three more cases of stroke per 1,000 people. On the plus side, ...
- Vegetarian and pescetarian diets linked to lower risk of coronary heart diseaseon September 4, 2019 at 3:32 pm
Vegetarian (including vegan) and pescetarian diets may be linked to a lower risk of coronary heart disease, or CHD for short, than diets that include meat, suggest the findings of a large UK study ...
via Bing News