Spinal cord stimulation and physical therapy have helped a man paralyzed since 2013 regain his ability to stand and walk with assistance. The results, achieved in a research collaboration between Mayo Clinic and UCLA, are reported in Nature Medicine.
With an implanted stimulator turned on, the man, Jered Chinnock, was able to step with a front-wheeled walker while trainers provided occasional assistance. He made 113 rehabilitation visits to Mayo Clinic over a year, and achieved milestones during individual sessions:
- Total distance: 111 yards (102 meters) — about the length of a football field
- Total number of steps: 331
- Total minutes walking with assistance:16 minutes
- Step speed: 13 yards per minute (0.20 meters per second)
“What this is teaching us is that those networks of neurons below a spinal cord injury still can function after paralysis,” says Kendall Lee, M.D., Ph.D., co-principal investigator, neurosurgeon and director of Mayo Clinic’s Neural Engineering Laboratories.
In the study, Chinnock’s spinal cord was stimulated by an implanted electrode, enabling neurons to receive the signal that he wanted to stand or step.
“Now I think the real challenge starts, and that’s understanding how this happened, why it happened, and which patients will respond, says Kristin Zhao, Ph.D., co-principal investigator and director of Mayo Clinic’s Assistive and Restorative Technology Laboratory.
Currently, as a safety precaution, Chinnock takes steps only under the supervision of the research team.
Chinnock, now 29, injured his spinal cord at the thoracic vertebrae in the middle of his back in a snowmobile accident in 2013. He was diagnosed with a complete loss of function below the spinal cord injury, meaning he could not move or feel anything below the middle of his torso.
In the study, which began in 2016, Chinnock participated in 22 weeks of physical therapy and then had an electrode surgically implanted by Dr. Lee and his Mayo Clinic neurosurgery team.
The implant sits in the epidural space — the outermost part of the spinal canal — at a specific location below the injured area. The electrode connects to a pulse generator device under the skin of Chinnock’s abdomen and communicates wirelessly with an external controller. Mayo Clinic received permission from the U.S. Food and Drug Administration to use the device for a condition not covered by its FDA-approved label.
The research team then tried to determine if Chinnock could stand and walk with assistance. During 113 rehabilitation sessions, the researchers adjusted stimulation settings, trainer assistance, harness support and speed of the treadmill to allow him maximum independence.
The research demonstrated that Chinnock was able to walk over ground using a front-wheeled walker and step on a treadmill placing his arms on support bars to help with balance. However, when stimulation was off, Chinnock remained paralyzed.
In the first week, Chinnock used a harness to lower his risk of falling and to provide upper body balance. Trainers were positioned at his knees and hips to help him stand, swing his legs and shift his weight. Because Chinnock did not regain sensation, he initially used mirrors to view his legs, and trainers described leg position, movement and balance. By week 25, he did not need a harness, and trainers offered only occasional help. By the end of the study period, he learned to use his entire body to transfer weight, maintain balance and propel forward, requiring minimal verbal cues and periodic glances at his legs.
The Latest on: Spinal cord stimulation
via Google News
The Latest on: Spinal cord stimulation
- 2019 Spinal Cord Stimulation Devices Market Size, Trends, Industry Analysis, Leading Players & Future Forecast till 2028on August 16, 2019 at 6:20 am
Aug 16, 2019 (Reporthive Research via COMTEX) -- Spinal Cord Stimulation Devices Market research report presents the readers with market overview and definitions, segmentation, applications, raw ...
- JHU Researchers Harmed Dogs, Animal Rights Group Argueson August 15, 2019 at 10:16 am
The Ohio-based group refers to a letter that Hopkins researchers sent to the National Institutes of Health about the termination of federally funded research on spinal cord stimulation as a treatment ...
- Meridian clinic first to perform new procedure in Mississippion August 14, 2019 at 2:24 pm
The spinal cord stimulator procedure has now been simplified. Dr. Azhar Pasha with the Pain Management Center of Meridian is the first to perform it in the state. The spinal cord stimulator procedure ...
- Spinal Cord Stimulation Devices Market is expected to see growth rate of 5.12% | Top Players: Medtronic, Nevro, Boston Scientificon August 14, 2019 at 10:08 am
Aug 14, 2019 (HTF Market Intelligence via COMTEX) -- Spinal cord stimulation devices are used for treating chronic pain by modifying and blocking the pain signals before they reach the brain to ...
- Feinstein Institutes trial finds promising non-invasive therapy for strokeon August 13, 2019 at 4:53 am
... a direct electrical current across the spinal cord with a skin surface electrode, known as trans-spinal direct current stimulation (tsDCS), and adding a peripheral direct current stimulation ...
- Neuromodulation Devices Market Report: Regional Data Analysis by Production, Revenue, Price and Gross Margin by 2027on August 9, 2019 at 12:07 pm
Most of the neuromodulation devices work through electrical stimulation.Neuromodulation devices are used by the application of electrodes to the brain, peripheral nerves or the spinal cord. The ...
- ‘It turned my life around’: Spinal cord stimulators help ease chronic painon August 7, 2019 at 3:30 pm
So when anesthesiologist Dr. Aaron Hong suggested she try a spinal cord stimulator to relieve her pain, she was eager. “Our pain group felt that if we introduced this type of technology ...
- Lysozyme elicits pain during nerve injury by neuronal Toll-like receptor 4 activation and has therapeutic potential in neuropathic painon August 7, 2019 at 12:20 pm
This also explains the delay between the time of lysozyme infusion to the spinal cord slices and the nerve fiber stimulation. Thus, lysozyme can affect the dorsal root afferent terminals to enhance ...
- How a Revolutionary Technique Got People with Spinal-Cord Injuries Back on Their Feeton August 7, 2019 at 6:02 am
Now he was part of a pioneering experiment to test the power of electrical stimulation in people with spinal-cord injuries. “Susie, look, I can wiggle my toe,” Summers said. Susan Harkema, a ...
via Bing News