New surfaces create promise of safer implants, more accurate diagnostic tests
Researchers at McMaster University have solved a vexing problem by engineering surface coatings that can repel everything, such as bacteria, viruses and living cells, but can be modified to permit beneficial exceptions.
The discovery holds significant promise for medical and other applications, making it possible for implants such as vascular grafts, replacement heart valves and artificial joints to bond to the body without risk of infection or blood clotting.
The new nanotechnology has the potential to greatly reduce false positives and negatives in medical tests by eliminating interference from non-target elements in blood and urine.
The research adds significant utility to completely repellent surfaces that have existed since 2011. Those surface coatings are useful for waterproofing phones and windshields, and repelling bacteria from food-preparation areas, for example, but have offered limited utility in medical applications where specific beneficial binding is required “It was a huge achievement to have completely repellent surfaces, but to maximize the benefits of such surfaces, we needed to create a selective door that would allow beneficial elements to bond with those surfaces,” explains Tohid DIdar of McMaster’s Department of Mechanical Engineering and School of Biomedical Engineering, the senior author of a paper that appears today in the journal ACS Nano.
In the case of a synthetic heart valve, for example, a repellent coating can prevent blood cells from sticking and forming clots, making it much safer.
“A coating that repels blood cells could potentially eliminate the need for medicines such as warfarin that are used after implants to cut the risk of clots,” says co-author Sara Imani, a McMaster PhD student in Biomedical Engineering.
Still, she explains, a completely repellent coating also prevents the body from integrating the new valve into the tissue of the heart itself.
By designing the surface to permit adhesion only with heart tissue cells, the researchers are making it possible for the body to integrate the new valve naturally, avoiding the complications of rejection. The same would be true for other implants, such as artificial joints and stents used to open blood vessels.
“If you want a device to perform better and not be rejected by the body, this is what you need to do,” says co-author Maryam Badv, also a McMaster PhD student in Biomedical Engineering. “It is a huge problem in medicine.”
Outside the body, selectively designed repellent surfaces could make diagnostic tests much more accurate by allowing only the particular target of a test – a virus, bacterium or cancer cell, for example – to stick to the biosensor that is looking for it, a critical advantage given the challenges of testing in complex fluids such as blood and urine.
The researchers, who collaborated with Jeffrey Weitz of the Thrombosis & Atherosclerosis Research Institute at Hamilton Health Sciences to understand the challenges related to making successful implants, are now working on the next stages of research to get their work into clinical use.
The Latest on: Smart surface
via Google News
The Latest on: Smart surface
- Surface Book 3 vs MacBook Pro 2020: Which pro laptop will in?on May 10, 2020 at 2:00 am
This Surface Book 3 vs MacBook Pro 2020 face-off comparison shows just how powerful today's laptops have become. Microsoft’s Surface Book 3 is one of the most capable 2-in-1 laptops around, witch up ...
- Smart home company about to start charging you monthly feeon May 9, 2020 at 8:02 pm
Wink is changing its business model from free services to paid subscriptions. Here's why they're doing it, and what it means for your smart home.
- Microsoft’s Surface Pro 7, Apple Watch Series 5 and more devices are on sale todayon May 8, 2020 at 12:03 pm
Today's deals include Microsoft's Surface Pro 7, several variants of the Apple Watch Series 5, huge discounts on TCL smart TVs and more ...
- Why the new Microsoft Surface devices don't have a webcam shutteron May 7, 2020 at 9:39 am
Microsoft believes that alerting users that their secured devices are on outweighs the need to put a physical camera shutter on devices like the Surface Book 3 and Surface Go 2.
- Xbox Series X Smart Delivery: Everything we knowon May 7, 2020 at 8:36 am
This is everything we know about Xbox Series X’s Smart Delivery feature, which enables cross-generation purchasing from Xbox One and the next console.
- The Morning After: Microsoft unveiled the Surface Book 3 and Surface Go 2on May 7, 2020 at 4:30 am
Microsoft's new Surface Book 3 and Surface Go 2 are here, along with some new headphones and a set of weird-looking earbuds. Plus, Wink is making smart homes look bad and Ring has updated its basic ...
- How the Surface Go 2 compares to other low-cost tabletson May 6, 2020 at 7:15 am
To help you decide which model is best for you, we’ve compared the Surface Go 2 with the iPad, the Galaxy Tab S6 Lite, and the Amazon Fire HD 10 in the table below. The table is best viewed in ...
- Microsoft’s new Surface Dock 2 is made for the USB-C eraon May 6, 2020 at 7:00 am
The Surface Dock 2 is not much of a design departure from Microsoft’s original model, which launched a handful of years ago; it’s basically a minimalist black slab. That said, it’s absolutely packed ...
- Microsoft debuts high-powered Surface Book 3 and portable Surface Go 2on May 6, 2020 at 6:57 am
The two represent different extremes in Microsoft’s hardware lineup, with the Surface Book 3 offering high-powered performance, and the Go designed as a low-cost, but travel-friendly device for ...
via Bing News