With today’s technology, we can 3-D-print sculptures, mechanical parts, prosthetics, even guns and food. But a team of University of Utah biomedical engineers have developed a method to 3-D-print cells to produce human tissue such as ligaments and tendons, a process that will greatly improve a patient’s recovery.
A person with a badly damaged ligament, tendon or ruptured disc could simply have new replacement tissue printed and ultimately implanted in the damaged area, according to a new paper published in the Journal of Tissue Engineering, Part C: Methods.
“It will allow patients to receive replacement tissues without additional surgeries and without having to harvest tissue from other sites, which has its own source of problems,” says University of Utah biomedical engineering assistant professor Robby Bowles, who co-authored the paper along with former U biomedical engineering master’s student, David Ede.
The 3-D-printing method, which took two years to research, involves taking stem cells from the patient’s own body fat and printing them on a layer of hydrogel to form a tendon or ligament which would later grow in vitro in a culture before being implanted. But it’s an extremely complicated process because that kind of connective tissue is made up of different cells in complex patterns. For example, cells that make up the tendon or ligament must then gradually shift to bone cells so the tissue can attach to the bone.
“This is a technique in a very controlled manner to create a pattern and organizations of cells that you couldn’t create with previous technologies,” Bowles says of the printing process. “It allows us to very specifically put cells where we want them.”
To do that, Bowles and his team worked with Salt Lake City-based company, Carterra, Inc., which develops microfluidic devices for medicine. Researchers used a 3-D printer from Carterra typically used to print antibodies for cancer screening applications. But Bowles’ team developed a special printhead for the printer that can lay down human cells in the controlled manner they require. To prove the concept, the team printed out genetically-modified cells that glow a fluorescent color so they can visualize the final product.
Currently, replacement tissue for patients can be harvested from another part of the patient’s body or sometimes from a cadaver, but it may be of poor quality. Spinal discs are complicated structures with bony interfaces that must be recreated to be successfully transplanted. This 3-D-printing technique can solve those problems.
Bowles, who specializes in musculoskeletal research, said the technology currently is designed for creating ligaments, tendons and spinal discs, but “it literally could be used for any type of tissue engineering application,” he says. It also could be applied to the 3-D printing of whole organs, an idea researchers have been studying for years. Bowles also says the technology in the printhead could be adapted for any kind of 3-D printer.
The Latest on: 3D Bioprinting
via Google News
The Latest on: 3D Bioprinting
- Tel Aviv University Researchers 3D-Print Human Heart on April 17, 2019 at 9:46 am
There has been significant progressin so-called bioprinting—using a type of 3D printing to manufacture biological tissues. But an actual organ hadn’t been accomplished—until now. 3D printing is ... […]
- Scientists manage to 3D print an actual heart using human cells on April 16, 2019 at 12:11 pm
One possibility involves 3D bioprinting, a type of 3D printing that uses living cells, growth factors, and biomaterials to fabricate biomedical parts. Eventually, the dream of 3D bioprinting is to be ... […]
- Bioprinting 101 – Part 13 Imaging Technology on April 16, 2019 at 1:08 am
A major development within bioprinting is the development of imaging technology. Radiology and imaging allows for precision image quality that leads to overall higher resolution 3D models of ... […]
- India- 3D Bioprinting Market 2019 Statistical Analysis to Reach Highs in Revenues By Size, Share and Trends Till 2023 on April 15, 2019 at 1:07 pm
(MENAFN - GetNews) MRFR is the Leading Brand in The Research Company who Recently Published 3D Bioprinting Research Reports which showcase an impressive growth at 24.59% CAGR from 2018 to 2023 to ... […]
- Finnish researchers create corneas using 3D bioprinters on April 15, 2019 at 9:11 am
Even so, Mörö said activity within the emerging 3D bioprinting industry is staggering, saying that nearly all of the tissues found in the human body can already be printed. But a good deal of research ... […]
- $385.56 Million 3D Bioprinting Market - Global Growth, Trends and Forecasts 2018-2019 & 2023 - ResearchAndMarkets.com on April 15, 2019 at 8:06 am
DUBLIN--(BUSINESS WIRE)--The "3D Bioprinting Market - Growth, Trends and Forecasts (2018 - 2023)" report has been added to ResearchAndMarkets.com's offering. The Global 3D Bioprinting Market was ... […]
- Cell-herding ultrasound developed for better bioprinting on April 11, 2019 at 10:38 am
We've been hearing a lot lately about how living cells can be combined with polymer gels, the mix then being 3D-printed to create ... adding it to existing bioprinting systems. […]
- 3D Bioprinting Market Future Growth Dynamics to 2028 : Analysis & Forecast Detailed Report by Future Market Insights on April 10, 2019 at 6:39 pm
Valley Cottage, NY -- (SBWIRE) -- 04/10/2019 -- Spritam (levetiracetam) is the first treatment with 3D bioprinting that gained FDA approval and was developed by Aprecia Pharmaceutical, a specialty ... […]
- 3D bioprinting chips away at glioblastomal resistance on April 10, 2019 at 11:35 am
3D-printed tumor-on-a-chip devices closely resembling tumor microenvironment help customize patient treatment regimens for glioblastoma. Glioblastoma is the most common and aggressive form of brain ... […]
via Bing News