While stem cells have the most therapeutic potential, the benefits of regenerative medicine may best be mobilised using extracellular vesicles (EVs), also known in the past as “cellular dust”.
A team of researchers from CNRS, AP-HP, INSERM and Paris Descartes and Paris Diderot Universities have tested these vesicles for the first time in a porcine model for the treatment of post-operative digestive fistulas. Their results, which yielded a 100% success rate and appear in the 23 October 2018 edition of ACS Nano, open the door to testing in humans and broader possibilities for applications.
Extracellular vesicles are matter that is released by cells. Seen for many years as not having any value, this ‘cellular dust’ has been studied and presents therapeutic properties similar to their mother cells, without their disadvantages: These vesicles do not divide, limiting the risk of cancer, and do not differentiate either, thus preventing the development of poor function. Furthermore, it appears that they can be produced by a single donor for several patients, and have already demonstrated their therapeutic potential in animals in repairing heart, liver and kidney lesions.
In the case of digestive fistula, in which there is abnormal communication between organs in the digestive tract or with the skin, regenerative medicine is an important therapeutic avenue to explore. Fistulas of this kind respond poorly to current treatments; they can develop following post-operative complications or an auto-immune disorders such as Crohn’s disease, which causes digestive tract dysfunction.
For the first time, scientists at the Matières et systèmes complexes Lab (CNRS/Université Paris Diderot), the Gastroenterology and Endoscopy Department at the Hôpital Européen Georges Pompidou (HEGP) AP-HP and the Laboratoire Imagerie de l’angiogénèse, plateforme d’imagerie du petit animal (INSERM/Université Paris Descartes/HEGP)1, used extracellular vesicles from stem cells to treat digestive fistula in a swine model. The study reveals that local injections into the fistula of a gel containing these vesicles results in the complete closure of post-operative digestive fistula.
Researchers intend to test the new approach in a perineal fistula model found in Crohn’s disease, with the hope of replacing the stem cell injections. The vesicle gel could be administered locally and easily and become a simpler, safer and more effective treatment.
The Latest on: Extracellular vesicles
via Google News
The Latest on: Extracellular vesicles
- New pathway for cell communication discovered on February 18, 2019 at 4:45 am
Small lipid vesicles known as extracellular vesicles are of great interest to cell scientists since it has been discovered that they mediate intercellular communication. Now, Professor Tom Carter ... […]
- The Regenerative Potential of Amniotic Fluid Stem Cell Extracellular Vesicles: Lessons Learned by Comparing Different Isolation Techniques on February 12, 2019 at 2:50 am
Extracellular vesicles (EVs) derived from amniotic fluid stem cells (AFSCs) mediate anti-apoptotic, pro-angiogenic, and immune-modulatory effects in multiple disease models, such as skeletal muscle at... […]
- Avalon GloboCare Announces Breakthrough in Identifying Human Angiogenic Exosomes/Extracellular Vesicles (EV) Derived from Endothelial Cells on February 11, 2019 at 5:32 am
February 11, 2019 08:30 ET | Source: Avalon GloboCare Corp. Angiogenic exosomes containing angiogenic factors developed to promote new blood vessel formation and tissue regeneration upon release ... […]
- Tumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA on February 10, 2019 at 3:29 pm
Carcinogenesis occurs in elastin-rich tissues and leads to local inflammation and elastolytic proteinase release. This contributes to bioactive matrix fragment (Matrikine) accumulation like elastin de... […]
- NanoView Biosciences’ Exosome Characterization Platform Wins Laboratory Automation Award on February 6, 2019 at 8:05 am
These extracellular vesicles play an important role in cell-to-cell communication, but their extremely small size makes them difficult to identify with sensitivity and specificity using existing techn... […]
- Protective Role of microRNA May Hold Therapeutic Potential for ALS, Study Shows on February 4, 2019 at 8:30 am
The study, “Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS,” was published in the journal EBioMedicine. ALS is a rare neurologi... […]
- BrainStorm to Present at 2019 BIO CEO & Investor Conference and Extracellular Vesicles in Diagnostics & Therapeutics Symposium on February 4, 2019 at 5:24 am
February 04, 2019 08:22 ET | Source: BrainStorm Cell Therapeutics Inc. NEW YORK, Feb. 04, 2019 (GLOBE NEWSWIRE) -- BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), a leader in developing innovative a... […]
- BrainStorm to Present at 2019 BIO CEO & Investor Conference and Extracellular Vesicles in Diagnostics & Therapeutics Symposium on February 3, 2019 at 4:00 pm
NEW YORK, Feb. 04, 2019 (GLOBE NEWSWIRE) -- BrainStorm Cell Therapeutics Inc. (BCLI), a leader in developing innovative autologous cellular therapies for highly debilitating neurodegenerative diseases ... […]
- Journal Highlight: Application of extracellular vesicles proteomics to cardiovascular disease: Guidelines, data analysis, and future perspectives on January 29, 2019 at 2:36 am
Barrachina, N.M., Calderón‐Cruz, B., Fernandez‐Rocca, L., et al. (2019). Application of extracellular vesicles proteomics to cardiovascular disease: Guidelines, data analysis, and future perspectives. ... […]
via Bing News