Natural product found to reduce the level of damaged cells in the body, caused by aging
Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person’s immune system is healthy and is able to clear the damaged cells. But as people age, they aren’t cleared as effectively. Thus they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
Robbins and fellow researchers found a natural product, called Fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. The paper, “Fisetin is a senotherapeutic that extends health and lifespan,” was recently published in EBioMedicine.
“These results suggest that we can extend the period of health, termed healthspan, even towards the end of life,” said Robbins. “But there are still many questions to address, including the right dosage, for example.”
One question they can now answer, however, is why haven’t they done this before? There were always key limitations when it came to figuring out how a drug will act on different tissues, different cells in an aging body. Researchers didn’t have a way to identify if a treatment was actually attacking the particular cells that are senescent, until now.
Under the guidance of Edgar Arriaga, a professor in the Department of Chemistry in the College of Science and Engineering at the University of Minnesota, the team used mass cytometry, or CyTOF, technology and applied it for the first time in aging research, which is unique to the University of Minnesota.
“In addition to showing that the drug works, this is the first demonstration that shows the effects of the drug on specific subsets of these damaged cells within a given tissue.” Robbins said.
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The Latest on: Fisetin
- Fisetin—a new senolytic on October 23, 2018 at 11:29 am
Senolytic drugs have been the most promising near-term anti-aging therapy since the ground-breaking paper by van Deursen of Mayo Clinic published in 2011. The body accumulates senescent cells as we ag... […]
- Op-Ed: Fisetin — Finally, an idiot-proof general health compound? on October 4, 2018 at 4:12 pm
Sydney - The anti-aging idea has been rattling along merrily, (and obscenely faddishly), for years. Research shows that Fisetin, which does critical work in counteracting aging, can also counter cause... […]
- Fisetin, a substance that can extend healthy life span, is contained in vegetables and fruits on October 4, 2018 at 1:00 pm
The damage accumulated by the cell accumulates as a person grows older, but this damage reaches a certain level or the necessary constituent elements are deficient, so cell division and growth stops. ... […]
- Anti-aging effects of compound in some fruits and vegetables verified in novel new research on October 3, 2018 at 8:08 am
Fisetin, a flavonoid found in many fruits and vegetables. may be an effective anti-aging compound(Credit: Serg64/Depositphotos) New research has revealed that fisetin – a natural flavonoid found in ma... […]
- Study: Fisetin Improved Health, Lengthened Lifespan Of Mice on October 2, 2018 at 9:23 pm
MINNEAPOLIS (WCCO) — Aging is a fact of life many of us would like to ignore. “One of the major challenges to our society right now is the increase of the aging population,” said chemistry professor E... […]
- Researchers discover how to slow aging on October 2, 2018 at 9:03 am
They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan. As people age, they ... […]
- Plant compound shows more evidence of cognition-protecting abilities, in animal testing on July 11, 2017 at 4:15 pm
Antonio Currais was the first author. Both work in the laboratory of David Schubert, also a study author. Previous research found that fisetin produces neuroprotective effects in another strain of mic... […]
- Natural Chemical Found in Strawberries May Protect against Age-Related Neurodegenerative Diseases on July 11, 2017 at 2:59 am
Researchers at the Salk Institute for Biological Studies have found further evidence that fisetin, a natural flavonoid found in strawberries and other edible fruits or vegetables, reduces cognitive de... […]
- Figure 5: The antihyperalgesic effect of fisetin (Fis) in neuropathic mice is mediated by spinal 5-HT on March 20, 2017 at 4:04 am
(A) Co-administration of 5-HT 7 receptor antagonist SB-258719 (1 mg/kg, i.p.) abrogated fisetin antihyperalgesia in CCI mice, without influencing the thermal sensitivity in sham or vehicle-treated CCI ... […]
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