Natural product found to reduce the level of damaged cells in the body, caused by aging
Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person’s immune system is healthy and is able to clear the damaged cells. But as people age, they aren’t cleared as effectively. Thus they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
Robbins and fellow researchers found a natural product, called Fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. The paper, “Fisetin is a senotherapeutic that extends health and lifespan,” was recently published in EBioMedicine.
“These results suggest that we can extend the period of health, termed healthspan, even towards the end of life,” said Robbins. “But there are still many questions to address, including the right dosage, for example.”
One question they can now answer, however, is why haven’t they done this before? There were always key limitations when it came to figuring out how a drug will act on different tissues, different cells in an aging body. Researchers didn’t have a way to identify if a treatment was actually attacking the particular cells that are senescent, until now.
Under the guidance of Edgar Arriaga, a professor in the Department of Chemistry in the College of Science and Engineering at the University of Minnesota, the team used mass cytometry, or CyTOF, technology and applied it for the first time in aging research, which is unique to the University of Minnesota.
“In addition to showing that the drug works, this is the first demonstration that shows the effects of the drug on specific subsets of these damaged cells within a given tissue.” Robbins said.
The Latest on: Fisetin
via Google News
The Latest on: Fisetin
- What Is Fisetin? And Does It Slow Dementia?on August 8, 2019 at 5:00 pm
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Log out Cancel ...
- A hydroxylated flavonol, fisetin inhibits the formation of a carcinogenic estrogen metabolite.on July 27, 2019 at 5:00 pm
Fisetin can be found in a wide variety of plants and possesses strong efficacy against many cancers. 17β-Estradiol (E2) is hydrolyzed to 4-hydroxy-E2 (4-OHE2) via cytochrome P450 (CYP) 1B1 in vivo. In ...
- Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathwayson February 13, 2019 at 2:49 am
Pancreatic cancer is one of the most aggressive tumors and patients have poor survival rates. Fisetin, a natural flavonoid, was recently reported to have antitumor effects in various cancer models.
- Fisetin: The flavonoid that can add years to your lifeon January 11, 2019 at 12:49 am
It has been found that having 37 whole strawberries can give you the optimal amount of fisetin. © Shutterstock As you age, your cells get damaged through oxidative stress and lose the ability to ...
- Fisetin: a drug to combat the aging process?on October 11, 2018 at 5:00 pm
Fisetin, a naturally-occurring chemical, has been identified as having anti-aging benefits, assisting the clearance of damaged, senescent cells. Recent research conducted in a collaboration between ...
- What is Fisetin?on October 10, 2018 at 5:00 pm
Fisetin is a safe natural flavonoid plant polyphenol compound found within numerous fruits and vegetables that may slow aging processes, helping people to live healthier and longer. Recently fisetin ...
- Fisetin May Be An Effective Senolyticon October 10, 2018 at 12:22 pm
Senolytic compounds have been suggested in animal studies that show promise to possibly destroying enough senescent cells in mammals to be worth investigating for use as first generation rejuvenation ...
- Op-Ed: Fisetin — Finally, an idiot-proof general health compound?on October 4, 2018 at 4:12 pm
Sydney - The anti-aging idea has been rattling along merrily, (and obscenely faddishly), for years. Research shows that Fisetin, which does critical work in counteracting aging, can also counter ...
- What is Fisetin? Product Found in Fruits and Vegetables May Slow Aging, Researchers Showon October 3, 2018 at 12:17 pm
A byproduct that occurs naturally in fruits and vegetables might help people live healthier and longer. Researchers at The Scripps Research Institute and the Mayo Clinic studied if fisetin, which is a ...
via Bing News