For the first time ever, Mount Sinai researchers have identified a protein as a marker that can indicate whether a cancer patient will develop a reoccurrence of lethal, metastatic cancer, according to a clinical study published in Breast Cancer Research in October.
The researchers found that when cells from a breast cancer patient’s original tumor metastasized into the patient’s bone marrow with none, or only a small amount, of the protein NR2F1, the patients all soon died. However, patients who had a high concentration of NR2F1 in the cancer cells in their bone marrow did not frequently develop this type of metastatic cancer, and lived longer. The presence of a high concentration of NR2F1 induced dormancy in the cancer cells, essentially deactivating them, so this research shows that survival in these patients is due to the dormancy of the disseminated cancer.
These findings suggest that the absence of this protein in cancer cells that have spread to a patient’s bone marrow can reliably signal that the patient will relapse soon and that additional treatment is needed, while if the protein is present, the cancer cells are dormant and the patient can be monitored rather than undergo unnecessary treatment. This research is particularly important because the most common breast type of breast cancer, when it metastasizes, almost always goes to the bone.
The research is especially important in the United States because bone marrow tests, called aspirates, are not used to monitor patients there. The study was a collaboration with physicians and scientists in Oslo, Norway, where bone marrow aspirates are used to monitor patients. The laboratory of Bjorn Naume from University Hospital of Oslo collaborated with the Aguirre-Ghiso and Sosa labs at the Icahn School of Medicine at Mount Sinai and conducted the analysis of the patients’ samples from their clinical trials, thus contributing significantly to this research.
Using this research, physicians could monitor their patients with bone marrow aspirates. Tests for the protein could also help clinicians identify patients who may benefit from recently identified drugs that were shown to target cancer cells and render or keep them dormant. Studies have already shown that androgen deprivation treatment, an anti-hormone therapy used in prostate cancer, has been linked to increasing levels of the NR2F1 protein. Mount Sinai, through a trial funded by the V Foundation for Cancer Research and The Tisch Cancer Institute at the Icahn School of Medicine, has already begun recruiting prostate cancer patients for a test of the ability of two drugs to induce dormancy through NR2F1 upregulation. “This research shows that the survival advantage in these patients is due to high levels of this protein. Tests using this protein marker could further improve curative treatment of breast cancer, sparing patients from unnecessary treatments. Identifying patients with disseminated disease that is not yet symptomatic and characterizing it for potential dormancy or metastatic recurrence is a game changer,” said lead researcher Julio Aguirre-Ghiso, PhD, Director of Solid Tumor and Metastasis Research, Director of Head and Neck Cancer Basic Research, and Professor of Oncological Sciences, Otolaryngology, and Medicine (Hematology and Medical Oncology) at The Tisch Cancer Institute at the Icahn School of Medicine. “Improved techniques to assess the population of patients with residual disease and their dormant or reactivating state will be key to identifying the risk of future metastasis despite undergoing standard treatment. This opens the way for testing new treatments that prevent metastasis by inducing dormancy or eradicating the dormant disseminated cancer cells that have not yet initiated metastatic growth.”
The Latest on: Breast cancer
via Google News
The Latest on: Breast cancer
- Health Watch: 6 lesser-known facts about breast canceron August 16, 2019 at 7:45 pm
With one in eight American women developing breast cancer, most of us know someone who has fought this terrible disease. However, there are some lesser-known breast cancer facts. Did you know that ...
- Breast cancer survivor Ericka Hart does self-exam on Instagram while dancing to 'Big Ole Freak'on August 16, 2019 at 11:26 am
Breast cancer survivor, model, writer and long-time sex health educator Ericka Hart took to Instagram this week to demonstrate an important hot girl survival skill — breast self-exams. Right before ...
- Obesity Effect on Cancer Risk Twice That Currently Thoughton August 16, 2019 at 11:13 am
For pancreatic and colorectal cancer, the MR estimate for every 5-unit increase in BMI was more than fourfold higher than WCRF estimates, the researchers add. For breast and lung cancer, MR estimates ...
- Chefs break taboo and talk openly about breast canceron August 16, 2019 at 10:00 am
When chef Dominique Crenn shared that she has breast cancer on Instagram this spring, it was shocking to many. That’s in part because she seems to have it all, from Michelin stars to TV appearances ...
- Breast Cancer Gene Mutation Also Increases Risk Of A Type Of Childhood Cancer, Says New Studyon August 16, 2019 at 8:35 am
Women with mutations in the BRCA1 or BRCA2 genes are well known to have an increased risk of developing both breast and ovarian cancer. As well as this, links have also been shown to both breast and ...
- Nordic walking may benefit breast cancer patientson August 16, 2019 at 8:00 am
(Reuters Health) - Nordic walking, an aerobic activity performed with walking poles similar to ski poles, may benefit patients with breast cancer, according to a review of existing research. The ...
- Women take legal action over breast implant cancer linkon August 16, 2019 at 4:15 am
Twenty UK women are taking legal action after developing a rare form of cancer linked to their breast implants. More than 50 women have been diagnosed with the same condition in the UK, and hundreds ...
- '90210' star Shannen Doherty gets candid on breast cancer battle: 'I’m lucky to be alive'on August 15, 2019 at 7:42 am
Shannen Doherty's battle with cancer impacted her body image, her outlook on life and her marriage. Though she's in remission now, the "Beverly Hills, 90210" star opened up to People about life after ...
- Living With Metastatic Breast Cancer: 5 Things to Knowon August 15, 2019 at 6:37 am
Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
via Bing News