A first-ever vaccine designed to deliver a one-two-three punch against the main causes of traveller’s diarrhea worldwide may result from new research published by a University of Guelph chemist.
Prof. Mario Monteiro says his novel three-in-one approach to developing a new vaccine could also save lives in developing countries, where it’s estimated that these three common pathogens kill more than 100,000 children under age five each year.
His research was recently published in the journal Vaccine.
The paper discusses Monteiro’s so-called conjugate vaccine that yokes together proteins from pathogenic E. coli with sugars from Shigella and Campylobacter jejuni. All three bugs are major causes of bacterial diarrhea globally.
In tests with mice, the vaccine provided immunity against all three pathogens.
No licensed vaccines exist against any of these pathogens. A sugar-based vaccine developed by Monteiro in 2009 against campylobacter alone is currently undergoing human trials but is still an estimated decade away from potential release.
He said this new three-in-one approach may ultimately overtake that earlier single-target vaccine, although any new vaccine may take decades to test and release. “We’re targeting three pathogens at the same time,” he said. “Instead of three shots, maybe you only need one.”
As with the earlier campylobacter vaccine, this new method has been patented by U of G and the United States Naval Medical Research Center, which funded the research.
Monteiro said further research is needed to determine the optimum amounts of protein and sugars in the vaccine and to make the vaccine more efficient.
The Latest on: Traveller’s diarrhea
via Google News
The Latest on: Traveller’s diarrhea
- Travel Health Essentials: Items Everyone Should Have In Their Suitcase on December 14, 2018 at 10:27 am
Seemingly minor ailments—a sunburn, headache, or travelers’ diarrhea—can really add up and put a damper on your trip. Have diabetes? Here are helpful tips to safely manage your blood sugar while abroa... […]
- Get vaccinated before you travel this holiday season on December 14, 2018 at 4:48 am
Don't travel if you have a fever and try to avoid crowds ... studies that it cuts down on the spread of gastroenteritis (stomach flu), infections and diarrhea so there's a lot of benefits of supplemen... […]
- Should you take probiotics on December 11, 2018 at 9:21 pm
Each of these has been shown to be effective against different types of diarrhea and constipation. I will describe three conditions experienced by adults. Traveler’s diarrhea: If you are planning to t... […]
- Measles alert for travellers on flight to Auckland from the Philippines on December 10, 2018 at 6:43 pm
Travellers on a flight from the Philippines are being contacted ... One in three people with measles will develop complications, such as ear infections, pneumonia, diarrhoea or rarely inflammation of ... […]
- Measles alert for travellers from Philippines on December 10, 2018 at 6:20 pm
One in three people with measles will develop complications, such as ear infections, pneumonia, diarrhoea or rarely inflammation of the brain. Dr Sinclair says if someone suspects they have measles, t... […]
- Traveler’s Diarrhea Therapeutics Sales Market Major Players Swot Analysis 2018 : GSK, Salix Pharmaceuticals, Chiesi Farmaceutici on December 10, 2018 at 4:46 am
Global Traveler’s Diarrhea Therapeutics Sales Market Insights, Forecast to 2023, The research report presents a comprehensive assessment of the market and contains strategic insights, facts, historica... […]
- Shigella can be caught during sex – leaving you with nasty diarrhoea and vomiting, expert warns on December 7, 2018 at 8:41 am
"If you think about cystitis in women, it’s often caused by germs that live in the bowel so if they can travel up the urethra they can absolutely ... If you have a shigella infection you will experien... […]
- The Global Water Crisis: What Travelers Need To Know on December 7, 2018 at 5:59 am
Travelers use water in all kinds of ways ... which often gets jumbled into the available groundwater and can cause illnesses like cholera and diarrhea. But, there are other things to be more aware abo... […]
- International travel poses risk to students’ health on December 6, 2018 at 12:27 am
However, the most common diseases students contracted were gastrointestinal infections, also known as “traveler’s diarrhea,” and dermatologic skin problems, according to Hamer. Upper-respiratory infec... […]
via Bing News