Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals.
The team hope the compound –developed after 10 years of painstaking research will be trialled on humans within three to four years.
The drug- which works by targeting Mycobacterium tuberculosis’ defences rather than the bacteria itself – can also take out its increasingly commonly antibiotic resistant strains.
The research funded by the Medical Research Council – is published today in the Journal of Medicinal Chemistry.
Although a vaccine for TB was developed 100 years ago, one in three people across the world are thought to be infected with the infectious disease.
About 1.7 million die from the bug each year worldwide and 7.3 million people were diagnosed and treated in 2018, up from the 6.3 million in 2016.
It is most common in Africa, India and China, but on the rise in the UK with London often described as the TB capital of Europe.
Patients are forced to take a cocktail of strong antibiotics over 6 to 8 months, often enduring unpleasant side effects with a 20% risk that the disease will return.
But now The University of Manchester team’s discovery has been proven effective in guinea pigs at Rutgers University in the United States.
The animals with acute and chronic TB infection were treated with the compound, which was discovered after investigating dozens of other derivatives and compounds thought to have similar properties.
Professor Lydia Tabernero is the project leader. She said: “The fact that the animal studies showed our compound, which doesn’t kill the bacteria directly, resulted in a significant reduction in the bacterial burden is remarkable.
“For more than 60 years, the only weapon doctors have been able to use against TB is antibiotics. But resistance is becoming an increasingly worrying problem and the prolonged treatment is difficult and distressing for patients.
“And with current treatments, there’s no guarantee the disease will be eliminated: antibiotics do not clear the infection and the risk of being infected with drug-resistant bacteria is very high.
“But by disabling this clandestine bacteria’s defences we’re thrilled to find a way that enhances the chances of the body’s immune system to do its job, and thus eliminate the pathogen.”
Mycobacterium Tuberculosis secretes molecules called Virulence Factors – the cell’s secret weapon -which block out the immune response to the infection, making it difficult to treat.
The team identified one Virulence Factor called MptpB as a suitable target, which when blocked allows white blood cells to kill Mycobacterium Tuberculosis in a more efficient way
Professor Tabernero added: “The great thing about MptpB is that there’s nothing similar in humans – so our compound which blocks it is not toxic to the human cells.
“Because the bacteria hasn’t been threatened directly, it is less likely to develop resistance against this new agent, and this will be a major advantage over current antibiotics, for which bacteria had already become resistant.
“TB is an amazingly difficult disease to treat so we feel this is a significant breakthrough.
”The next stage of our research is to optimise further the chemical compound, but we hope clinical trials are up to four years away.”
Learn more: Scientists develop new drug treatment for TB
The Latest on: Tuberculosis
via Google News
The Latest on: Tuberculosis
- Mascot Group of Institutions organised ‘Tuberculosis Patient Adoption Programme’on November 30, 2019 at 12:54 am
In a maiden initiative, Mascot College and Group of Institutions organised ‘Tuberculosis Patient Adoption Programme’ recently, which was inaugurated by Santosh Kumar Gangwar, Minister of State ...
- 'Can I sponsor my wife if she suffered tuberculosis nine years ago?'on November 29, 2019 at 10:04 pm
Will I still be able to sponsor my wife to live in Dubai with me and our children? UA, UK While the UAE has concerns regarding TB (tuberculosis), having suffered from the condition in the past does ...
- Tiruchy records decline in deaths due to tuberculosis, HIVon November 29, 2019 at 9:43 pm
TIRUCHY: India accounts for a quarter of the world’s TB burden, with an estimated 27 lakh cases in 2018, according to ‘India TB Report 2019’. While the number of notified TB patients has increased by ...
- Improved Alere Determine Lipoarabinomannan Antigen Detection Test for the Diagnosis of Human and Bovine Tuberculosis by Manipulating Urine and Milkon November 29, 2019 at 3:15 am
Tuberculosis (TB) disease still kills 1-person every 21-seconds. Few TB diagnostic tests are considered truly appropriate for point of care settings. The WHO-endorsed immunodiagnostic Alere Determine ...
- Bridging the gap between efficacy trials and model-based impact evaluation for new tuberculosis vaccineson November 29, 2019 at 2:22 am
In Tuberculosis (TB), given the complexity of its transmission dynamics, observations of reduced epidemiological risk associated with preventive interventions can be difficult to translate into ...
- UK scientists develop a tuberculosis vaccine that could help stop the spread of the deadly diseaseon November 28, 2019 at 8:42 am
A new vaccine that could stop the spread of tuberculosis in cattle is offering wildlife groups hope that it could see the end of badger culls. Researchers from the University of Surrey have created a ...
- New vaccine will stop the spread of bovine tuberculosison November 28, 2019 at 2:03 am
Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis (bovine TB). Publishing their findings in the journal ...
- Here's why the state didn't notify the public about the Bayhealth tuberculosis exposureon November 27, 2019 at 4:25 am
Here's why the state didn't notify the public about the Bayhealth tuberculosis exposure "Not everyone at the location was a risk," Dr. Rick Hong, state medical director, said about the Bayhealth ...
- Tuberculosis diagnosis at Moncton high school has mother feeling left in the darkon November 26, 2019 at 11:56 am
1:27 Mother wants more answers about tuberculosis case at Moncton school WATCH: After learning of a case of tuberculosis at her daughter's school, a Moncton mother is still looking for more answers.
via Bing News