Lego block” artificial cells that can kill bacteria have been created by researchers at the University of California, Davis, Department of Biomedical Engineering. The work is reported Aug. 29 in the journal ACS Applied Materials & Interfaces.
“We engineered artificial cells from the bottom-up — like Lego blocks — to destroy bacteria,” said Assistant Professor Cheemeng Tan, who led the work. The cells are built from liposomes, or bubbles with a cell-like lipid membrane, and purified cellular components including proteins, DNA and metabolites.
“We demonstrated that artificial cells can sense, react and interact with bacteria, as well as function as systems that both detect and kill bacteria with little dependence on their environment,” Tan said.
The team’s artificial cells mimic the essential features of live cells, but are short-lived and cannot divide to reproduce themselves. The cells were designed to respond to a unique chemical signature on E. coli bacteria. They were able to detect, attack and destroy the bacteria in laboratory experiments.
Artificial cells previously only had been successful in nutrient-rich environments, Tan said. However, by optimizing the artificial cells’ membranes, cytosol and genetic circuits, the team made them work in a wide variety of environments with very limited resources such as water, emphasizing their robustness in less-than-ideal or changing conditions. These improvements significantly broaden the overall potential application of artificial cells.
Antibacterial artificial cells might one day be infused into patients to tackle infections resistant to other treatments. They might also be used to deliver drugs at the specific location and time, or as biosensors.
Learn more: Artificial Cells Are Tiny Bacteria Fighters
The Latest on: Artificial cells
via Google News
The Latest on: Artificial cells
- Scientists advance creation of 'artificial lymph node' to fight cancer, other diseases on April 18, 2019 at 8:35 am
The work puts scientists a step closer, they say, to injecting such artificial lymph nodes into people and sparking T-cells to fight disease. In the past few years, a wave of discoveries has advanced ... […]
- Researchers create 3-D printed heart using patient's cells on April 18, 2019 at 12:11 am
For the first time ever, Israeli scientists in Tel Aviv made a 3-D printed artificial heart using a patient's own cells. This health app shares information with users' employers. Here's why that could ... […]
- Scientists create artificial material capable of metabolism, self-assembly, movement, and organization — key traits of life on April 17, 2019 at 10:41 am
The goal is not to produce artificial life, but rather to use the system as a biosensor or as a dynamic template for making proteins without living cells. […]
- Dead pig brains bathed in artificial fluid showed signs of cellular life on April 17, 2019 at 10:38 am
studies on individual cells in brain slices showed. In contrast, brains that weren’t in the BrainEx system deteriorated. PUMP IT An artificial fluid courses through this pig brain after death, keeping ... […]
- Artificial Intelligence In The Dairy Barn on April 17, 2019 at 9:36 am
So, it's no surprise that an Irish agtech company called Cainthus would invent a way to use artificial intelligence—the same technology ... until we already have cell counts that end up affecting milk ... […]
- Researchers just 3D-printed a heart from human cells. Here's why scientists are excited ... and concerned on April 17, 2019 at 8:28 am
Scientists in Israel have 3D-printed an artificial heart using human cells, according to research published Monday in the journal Advanced Science. "This is the first time anyone anywhere has ... […]
- 3D-Printed Heart Created by Israeli Researchers in World First: ‘This Heart Is Made From Human Cells’ on April 17, 2019 at 6:45 am
"The cells need to form a pumping ability ... “3D-printing a blood vessel is extremely challenging, as artificial blood vessels tend to burst over time. The current 3D-printed human hearts are ... […]
- Researchers claim they've 3D-printed artificial heart using patient's cells on April 15, 2019 at 9:32 pm
There's been a potential breakthrough in making organs in the lab. Israeli researchers have 3D printed a heart, complete with muscle and blood vessels. But how long before it is ready for actual use? ... […]
- Scientists develop artificial chemical receptor to assist viral transduction for T cell engineering on April 15, 2019 at 6:26 am
Engineered T cell immunotherapy, such as chimeric antigen receptor T cell (CAR-T) and T cell receptor T cell (TCR-T) therapy, has emerged as a potent therapeutic strategy for treating tumors. […]
- Artificial Cells That Make Their Own Energy Could Shed Light On How Life Came To Be on April 9, 2019 at 5:10 am
Scientists have managed to create artificial cells that produce their own energy via photosynthesis, a process used by plants and a few other organisms that involves harnessing energy from the Sun. ... […]
via Bing News