A new diagnostic tool has been developed by researchers at The University of Texas at Austin that can easily, quickly and cheaply identify whether a mosquito belongs to the species that carries dangerous diseases such as Zika virus, dengue, chikungunya or yellow fever. It can also determine whether the bug has come into contact with a mosquito-control strategy known as Wolbachia.
“Many of these diseases are spreading in areas where they weren’t common before,” said Sanchita Bhadra, a research associate in the Department of Molecular Biosciences and first author on the paper. “Having surveillance is important in conjunction with any kind of outbreak, and this method allows a rapid test in the field.”
The tool uses a smartphone camera, a small 3D-printed box and a simple chemical test to show whether a dead mosquito belongs to the Aedes aegypti species. Aedes aegypti carries Zika and other devastating viruses that afflict an estimated 100 million people worldwide each year. The species also is closely linked to the tripling of cases of mosquito-borne diseases in the United States since 2004.
The research appears in the journal PLOS Neglected Tropical Diseases.
The tool developed by scientists and students at UT Austin also detects the presence of a biopesticide called Wolbachia, a type of bacteria that keeps mosquitoes from spreading diseases. In countries around the world and in 20 U.S. states where the Aedes aegypti mosquito is found, scientists working in public health agencies have started to infect mosquitoes with Wolbachia by introducing the bacteria into a local mosquito population to help curb transmission of viruses.
Because mosquitoes show no outward signs of having the bacteria – and because existing diagnostic tests are hard to read, expensive and logistically cumbersome – the new tool represents a significant step forward for those hoping to monitor the effectiveness of Wolbachia.
“This test can happen without involving a lot of staff and equipment to make sure Wolbachia is effective and spreading as anticipated,” Bhadra said.
Public health groups trap and kill mosquitoes routinely in conjunction with monitoring efforts, but existing technology requires a complex process to extract nucleic acid from inside mosquitoes, often after they have been dead for days and have started to decay, leading to greater expense and the possibility of more errors in lab tests than the new technology.
The new diagnostic tool uses a smartphone’s camera and a simple test that can be done anywhere. It tests mosquitoes’ nucleic acid without requiring a complicated process to remove it. Officially known as a loop-mediated isothermal amplification and oligonucleotide strand displacement, or LAMP OSD, the probe delivers a simple yes-or-no readout on a cellphone, with accuracy of greater than 97 percent.
In addition to the tests to detect mosquito species and Wolbachia, the team also is exploring use of the technology to easily identify whether trapped mosquitoes are carrying Zika, dengue and other pathogens.
The Latest on: Disease diagnostic tool
via Google News
The Latest on: Disease diagnostic tool
- PathAI raises $60 million for AI pathology and diagnostic tools on April 17, 2019 at 9:24 am
Boston, Massachusetts-based PathAI, which was founded in 2015, supplies AI-powered research tools and services ... accuracy and reproducibility of disease diagnosis and support the development ... […]
- Global Cervical Cancer Diagnostics & Therapeutics Market Forecasts to 2024 - ResearchAndMarkets.com on April 17, 2019 at 7:55 am
The cervical cancer mortality rate is higher in developing countries, due to improper detection at early stages of the disease ... Under Diagnostic Test, is Expected to Grow During the Forecast Period ... […]
- Infectious Disease Diagnostics Market Growth Rate, Trending Factors and Industry Size 2026 on April 17, 2019 at 2:37 am
Valley Cottage, NY -- (SBWIRE) -- 04/17/2019 -- Infectious disease diagnostics is process of identifying the presence of foreign antigen/organism with the help of various diagnostic tools. Infectious ... […]
- The Leukemia Atlas: researchers unveil proteins that signal disease on April 17, 2019 at 1:48 am
Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis ... build from the resource and tools. Credit: UTSA To better ... […]
- Ortho's VITROS® High Sensitivity Troponin I Assay for the Diagnosis of Heart Attack Now CE Marked, Available in EU Countries on April 16, 2019 at 6:41 am
Heart disease and stroke statistics—2016 update: a report from the American Heart Association. Circulation. 2016;133:e38-e360. About Ortho Clinical Diagnostics Ortho Clinical Diagnostics is a ... […]
- QxMD Adapts Scientific Papers into Interactive Clinical Decision Support Tools on April 15, 2019 at 11:35 am
Most importantly, patient populations benefit from healthcare providers’ ability to access resources that enhance early disease detection and diagnosis, medical intervention, and therapeutic treatment ... […]
- Gastrointestinal diagnosis using non-white light imaging capsule endoscopy on April 15, 2019 at 8:12 am
Capsule endoscopy (CE) has proved to be a powerful tool in the diagnosis and management ... CE is limited to mucosal inspection, with diagnosis remaining reliant on visible manifestations of disease. ... […]
- Sharon Regional adds heart disease diagnostic tool on April 10, 2019 at 10:20 am
Sharon Regional Medical Center has adopted the Heart-Flow Analysis, a first-of-itskind, noninvasive technology to aid physicians in the diagnoses of coronary artery disease (CAD), the most common form ... […]
- Bionics Engineers Develop New Tool To Detect Parkinson's Disease on April 10, 2019 at 12:00 am
Bionics engineers have developed an exciting tool to help in the early diagnosis of Parkinson's disease. The hand worn device nicknamed 'The Bird', picks up a subtle muscle movement, saving patients ... […]
- New tools and strategies for tuberculosis diagnosis, care, and elimination: A PLOS Medicine special on April 5, 2019 at 5:37 pm
Last year the United Nations held a High Level Meeting on TB, where heads of state pledged to eliminate the disease by 2030 ... They provide a web-based tool to further explore this model and ... […]
via Bing News