In an industrial collaboration project, TU Wien has developed a medication that can alleviate or even completely eliminate the symptoms of celiac disease. It should be available as early as 2021.
Celiac disease is a fairly common disease, affecting one to two percent of the European population. It is expressed as a hypersensitivity to gluten, a protein found in cereals such as wheat, barley or rye.
Although efforts are already being made to treat celiac disease, the proposed drugs have an effect on the immune system. Possible side effects must therefore be examined very carefully. Although initial clinical studies are underway, they will not lead to a marketable product in the next few years.
For this reason, an entirely different approach has been pursued at TU Wien in collaboration with the industrial partner Sciotech Diagnostic Technologies GmbH. Instead of developing a drug that interferes with the immune system, TU Wien has created a simple medical product that directly attacks the gluten molecules to render them harmless. This makes the approval process much simpler, meaning that the product should be available in ordinary pharmacies as early as 2021.
Molecules like keys and locks
“Our bodies produce antibodies that fit intruding antigens precisely, like a key to a lock. This immune response makes these antigens harmless,” explains Professor Oliver Spadiut, head of the Integrated Bioprocess Development Research Group at TU Wien. “If a new antibody fragment is found and produced that docks to and blocks the invading gluten molecule without triggering the immune system, the symptoms of celiac disease can be suppressed.”
The aim of the research project was therefore to produce a complex of two such antibody fragments that envelop the gluten molecule at a molecular level, so that it can no longer have any further effects in the intestines.
To do this, certain bacteria have to be reprogrammed so that they produce exactly the desired antibody fragment. “The formation of such proteins in a bacterium is a highly complicated process,” explains Oliver Spadiut. “It can easily happen that the proteins are not folded exactly as we want.” Instead of the desired antibody fragments, so-called “inclusion bodies” are formed – small particles consisting of incorrectly folded proteins. A process therefore had to be developed to refold these inclusion bodies and to obtain the desired proteins from them.
Such processes, in which the folding of proteins is specifically altered, have not yet been studied in great detail and so they are not very efficient. “You have to precisely understand the chemical processes involved and intervene in a complicated way,” says Oliver Spadiut. “It has therefore taken a while, but we have now developed a process that can be easily reproduced, can be scaled up to industrial application and delivers a very good yield of the desired product”
In pharmacies soon
The project was supported by the industrial partner SCIOTEC Diagnostic Technologies GmbH, who will now bring the new medical product to the market. “It will be a preparation that celiac patients can take together with gluten-containing foods to alleviate coeliac symptoms,” explains Oliver Spadiut. “It remains to be seen whether the symptoms will disappear completely or will only be alleviated. The precise effects will probably vary from person to person.
Learn more: A new remedy for celiac disease
The Latest on: Celiac disease
via Google News
The Latest on: Celiac disease
- Dangerous Fad Soy Sauce ‘Cleanse’ Kills Woman with Possible Celiac Disease on December 17, 2018 at 8:37 am
CG had been unwell for weeks before the incident. She had begun a diet made up exclusively of white bread and canned fish six months prior, and had lost 11kg, nearly 25 pounds, in the three weeks lead... […]
- Medical Researchers Find a Biomarker for Non-Celiac Gluten Sensitivity on December 17, 2018 at 7:36 am
Although only an estimated 1% of the US population has celiac disease, millions more, 11% of US households, eat gluten free. Celiac is an autoimmune disease whereby the immune cells attack the lining ... […]
- More millennials navigating life with celiac disease on December 16, 2018 at 8:16 pm
Celiac disease is estimated to affect about 1 in 100 people worldwide, but diagnoses are climbing for millennials, according to Dr. Ben Lebwohl, director of clinical research at the Celiac Disease Cen... […]
- New vaccine may protect people with celiac disease from gluten exposure on December 16, 2018 at 4:30 am
This article originally appeared on Healthline, the world’s second-largest health information website, which brings you transparent health information so you can make confident decisions for living we... […]
- Ask the doctors: Going gluten-free brings relief for celiac disease on December 15, 2018 at 3:00 am
Q: My 40-year-old grandson has just been diagnosed with celiac disease after months of feeling poorly and being underweight. What's next? Where can he go for guidance and what should he do? I want to ... […]
- Brainy Camps Association Launches the ‘Be Gluten Free Family Camp’ for Youth with Celiac Disease on December 13, 2018 at 5:04 pm
WASHINGTON, D.C., Dec. 13, 2018 (SEND2PRESS NEWSWIRE) — Brainy Camps Association, which provides camps for children with chronic health conditions, announced that it will be launching a family camp fo... […]
- 14 Facts About Celiac Disease on December 13, 2018 at 1:11 pm
Going gluten-free may be a modern diet trend, but people have been suffering from celiac disease—a chronic condition characterized by gluten intolerance—for centuries. Patients with celiac are ... […]
- Gluten-free diet not healthy for you (unless you have celiac disease) on December 13, 2018 at 10:58 am
(CNN) - There was a time when gluten, a mixture of proteins found in wheat, rye and barley, was something of a foreign term. Not many people had heard of it, and the few who needed to avoid it found m... […]
- Is Wine Gluten-Free and Safe for People with Celiac Disease? on December 13, 2018 at 9:46 am
Wine is generally regarded as gluten-free and safe for people with celiac disease and other gluten-related sensitivities. That said, there are a couple of ways that wine could come to contain gluten; ... […]
via Bing News