In an industrial collaboration project, TU Wien has developed a medication that can alleviate or even completely eliminate the symptoms of celiac disease. It should be available as early as 2021.
Celiac disease is a fairly common disease, affecting one to two percent of the European population. It is expressed as a hypersensitivity to gluten, a protein found in cereals such as wheat, barley or rye.
Although efforts are already being made to treat celiac disease, the proposed drugs have an effect on the immune system. Possible side effects must therefore be examined very carefully. Although initial clinical studies are underway, they will not lead to a marketable product in the next few years.
For this reason, an entirely different approach has been pursued at TU Wien in collaboration with the industrial partner Sciotech Diagnostic Technologies GmbH. Instead of developing a drug that interferes with the immune system, TU Wien has created a simple medical product that directly attacks the gluten molecules to render them harmless. This makes the approval process much simpler, meaning that the product should be available in ordinary pharmacies as early as 2021.
Molecules like keys and locks
“Our bodies produce antibodies that fit intruding antigens precisely, like a key to a lock. This immune response makes these antigens harmless,” explains Professor Oliver Spadiut, head of the Integrated Bioprocess Development Research Group at TU Wien. “If a new antibody fragment is found and produced that docks to and blocks the invading gluten molecule without triggering the immune system, the symptoms of celiac disease can be suppressed.”
The aim of the research project was therefore to produce a complex of two such antibody fragments that envelop the gluten molecule at a molecular level, so that it can no longer have any further effects in the intestines.
To do this, certain bacteria have to be reprogrammed so that they produce exactly the desired antibody fragment. “The formation of such proteins in a bacterium is a highly complicated process,” explains Oliver Spadiut. “It can easily happen that the proteins are not folded exactly as we want.” Instead of the desired antibody fragments, so-called “inclusion bodies” are formed – small particles consisting of incorrectly folded proteins. A process therefore had to be developed to refold these inclusion bodies and to obtain the desired proteins from them.
Such processes, in which the folding of proteins is specifically altered, have not yet been studied in great detail and so they are not very efficient. “You have to precisely understand the chemical processes involved and intervene in a complicated way,” says Oliver Spadiut. “It has therefore taken a while, but we have now developed a process that can be easily reproduced, can be scaled up to industrial application and delivers a very good yield of the desired product”
In pharmacies soon
The project was supported by the industrial partner SCIOTEC Diagnostic Technologies GmbH, who will now bring the new medical product to the market. “It will be a preparation that celiac patients can take together with gluten-containing foods to alleviate coeliac symptoms,” explains Oliver Spadiut. “It remains to be seen whether the symptoms will disappear completely or will only be alleviated. The precise effects will probably vary from person to person.
Learn more: A new remedy for celiac disease
Receive an email update when we add a new CELIAC DISEASE article.
The Latest on: Celiac disease
via Google News
The Latest on: Celiac disease
- Could Molecular Mimicry of Human Ubiquitin by Gut Microbe Trigger Autoimmune Disease? on November 13, 2018 at 8:36 am
Is molecular mimicry of human ubiquitin by gut microbe linked to autoimmune diseases like celiac disease? A team of researchers recently set out to determine if there was antigenic cross‐reactivity be... […]
- Vaccine might allow Celiac disease patients to eat gluten on November 8, 2018 at 8:57 am
About 1% of the global population suffers from celiac disease, an autoimmune disorder that damages the small intestine when a person ingests gluten. But a new treatment currently in phase II clinical ... […]
- This vaccine could help people with celiac eat gluten again, but it's not for everyone on November 8, 2018 at 8:14 am
Millions of people with celiac disease spend their lives fretting over cross-contamination at restaurants and scrutinizing labels. It’s a lot of paranoia and watching other people eat cake. Worst of a... […]
- Vaccine for celiac disease has sufferers worried on November 7, 2018 at 4:11 pm
FARGO, N.D. (Valley News Live)-"If people didn't have to eat gluten free it would be good, I suppose. But at the same time, we want to make sure before we would support anything like that," Mark Mehl, ... […]
- Vaccine could bring hope to sufferers of celiac disease on November 7, 2018 at 7:43 am
There’s new hope for those who suffer from celiac disease who have to live a gluten-free lifestyle - a vaccine could either lessen the symptoms or even eradicate them. Nexvax2 has now cleared the firs... […]
- Gluten-free fix? What to know about an experimental treatment that could let celiac disease sufferers eat gluten on November 7, 2018 at 6:36 am
People who suffer from celiac disease must eat a strict, gluten-free diet but a new treatment currently being tested could, if clinical trials work and it's approved, change that. The treatment ... […]
- Vaccine for celiac disease may allow people to eat gluten again on November 6, 2018 at 8:12 pm
MINNEAPOLIS - Some possible good news for anyone with Celiac disease. A new vaccine is in the works that might let you eat all the pasta and bread you want. The company ImmusanT announced its experime... […]
- Celiac Disease Vaccine Might Allow Gluten-Free Eaters to Have Bread Again on November 6, 2018 at 10:48 am
Good news for people with celiac disease: you might be able to eat bread again someday. Nexvax2, a vaccine targeting the immune system with the intention of preventing inflammation that occurs when pe... […]
- Celiac Disease Vaccine In Clinical Trials Would Let People Eat Gluten Again on November 6, 2018 at 10:03 am
For years, people with Celiac disease have lived with the knowledge that there’s no cure for this autoimmune condition, and the only treatment is a strict gluten-free diet. Now, there’s a good ... […]
via Bing News