An international team of researchers have developed a low-cost sensor made from semiconducting plastic that can be used to diagnose or monitor a wide range of health conditions, such as surgical complications or neurodegenerative diseases.
This work opens up new directions in biosensing, where materials can be designed to interact with a specific metabolite, resulting in far more sensitive and selective sensors.
The sensor can measure the amount of critical metabolites, such as lactate or glucose, that are present in sweat, tears, saliva or blood, and, when incorporated into a diagnostic device, could allow health conditions to be monitored quickly, cheaply and accurately. The new device has a far simpler design than existing sensors, and opens up a wide range of new possibilities for health monitoring down to the cellular level. The results are reported in the journal Science Advances.
The device was developed by a team led by the University of Cambridge and King Abdullah University of Science and Technology (KAUST) in Saudi Arabia. Semiconducting plastics such as those used in the current work are being developed for use in solar cells and flexible electronics, but have not yet seen widespread use in biological applications.
“In our work, we’ve overcome many of the limitations of conventional electrochemical biosensors that incorporate enzymes as the sensing material,” said lead author Dr Anna-Maria Pappa, a postdoctoral researcher in Cambridge’s Department of Chemical Engineering and Biotechnology. “In conventional biosensors, the communication between the sensor’s electrode and the sensing material is not very efficient, so it’s been necessary to add molecular wires to facilitate and ‘boost’ the signal.”
To build their sensor, Pappa and her colleagues used a newly-synthesised polymer developed at Imperial College that acts as a molecular wire, directly accepting the electrons produced during electrochemical reactions. When the material comes into contact with a liquid such as sweat, tears or blood, it absorbs ions and swells, becoming merged with the liquid. This leads to significantly higher sensitivity compared to traditional sensors made of metal electrodes.
Additionally, when the sensors are incorporated into more complex circuits, such as transistors, the signal can be amplified and respond to tiny fluctuations in metabolite concentration, despite the tiny size of the devices.
Initial tests of the sensors were used to measure levels of lactate, which is useful in fitness applications or to monitor patients following surgery. However, according to the researchers, the sensor can be easily modified to detect other metabolites, such as glucose or cholesterol by incorporating the appropriate enzyme, and the concentration range that the sensor can detect can be adjusted by changing the device’s geometry.
“This is the first time that it’s been possible to use an electron accepting polymer that can be tailored to improve communication with the enzymes, which allows for the direct detection of a metabolite: this hasn’t been straightforward until now,” said Pappa. “It opens up new directions in biosensing, where materials can be designed to interact with a specific metabolite, resulting in far more sensitive and selective sensors.”
Since the sensor does not consist of metals such as gold or platinum, it can be manufactured at a lower cost and can be easily incorporated in flexible and stretchable substrates, enabling their implementation in wearable or implantable sensing applications.
“An implantable device could allow us to monitor the metabolic activity of the brain in real time under stress conditions, such as during or immediately before a seizure and could be used to predict seizures or to assess treatment,” said Pappa.
The researchers now plan to develop the sensor to monitor metabolic activity of human cells in real time outside the body. The Bioelectronic Systems and Technologies group where Pappa is based is focused on developing models that can closely mimic our organs, along with technologies that can accurately assess them in real-time. The developed sensor technology can be used with these models to test the potency or toxicity of drugs.
The Latest on: Biosensing
via Google News
The Latest on: Biosensing
- An ultrasensitive rolled-up microtube optofluidic biosensor integrated with molybdenum disulfide nanolayeron November 29, 2019 at 4:06 am
Though research advances have been made, whispering-gallery-mode (WGM) biosensing, which is one of most sensitive optical biosensing mechanisms, has not been realized on 2D MoS2, despite its superior ...
- Archer Materials’ graphene ink formulations printed and tested with prototype deviceon November 25, 2019 at 5:03 pm
Graphene ink formulations produced from the inventory of Carbon Allotropes, a wholly-owned subsidiary of Archer, have been successfully printed and tested in a prototype device for biosensing. This ...
- ‘Femtech’ wanders into uncharted regulatory territoryon November 20, 2019 at 12:57 pm
The range of women’s health needs addressed by Femtech is far-reaching. It includes fertility and menstruation tracking; pelvic floor strengthening; contraceptives; and “smart” biosensing technologies ...
- Dual-emission Ratiometric Fluorescence Probeson November 20, 2019 at 3:07 am
Image Credit: anyaivanova / Shutterstock.com Biomarker-based detection is essential in the diagnosis and treatment of disease. The ability to detect these biomarkers is dependent on chemo/biosensing ...
- Nanotechnology for disease diagnosis and treatment earns Florida Poly professor international awardon November 18, 2019 at 10:20 pm
LAKELAND, Fla., Nov. 18, 2019 /PRNewswire-PRWeb/ -- Dr. Ajeet Kaushik is determined to make detecting and treating diseases easy, accessible, and precise through the use of nanomaterials for ...
- The global bioactive wound care market is growing at a CAGR of over 6% during the forecast period 2018-2024on November 18, 2019 at 12:25 pm
Recent developments in the dressings with micro-fibers and biosensing for smart wound dressing enable quantitative, real-time representation of the wound environment, including pathogen concentrations ...
- CRISPR: More than just for gene editing?on November 10, 2019 at 9:12 pm
Case Western Reserve University researchers see a different opportunity in the CRISPR technique: A new "universal biosensing" point-of-care medical device--similar to the existing commercial blood ...
- University of Bristol spin-out raises £760,000 to commercialise biosensing technologyon October 30, 2019 at 11:36 pm
The artificial Intelligence (AI)-driven biosensing technology, which mimics mammals’ sense of smell, has significant potential to transform the medical diagnostics and pharmaceuticals industries. From ...
- FreeStyle Libre 14 day System: Interview with Chris Thomas, Director of Biosensing Technology, Abbotton September 20, 2019 at 10:09 am
See a promotional video from Abbott about the system below. Medgadget had the opportunity to talk to Chris Thomas, director of biosensing technology at Abbott, to discuss advancements in this field ...
via Bing News