A new technique for precisely targeting molecules within cells is paving the way for safer drugs that are free of side effects.
Researcher J. Julius Zhu, PhD, of the School of Medicine, and his colleagues have developed a way to manipulate molecules from compartment to compartment within individual cells. Amazingly, the same molecules do different things depending on their location, the researchers determined. By manipulating the molecules, scientists can determine exactly which locations to target with treatments, while avoiding locations that would cause harmful side effects. That will lead to safer drugs and more effective treatments.
“The problem with side effects is caused because you just could not distinguish the molecules doing different things in the same cell,” Zhu explained. “If you blocked a molecule, you blocked it regardless of what it was doing. And that usually has unwanted side effects. Almost every drug that can treat disease has side effects, either major or minor, but usually they always have something.”
More Precise Precision Medicine
Until now, drugs have targeted molecules in a very general way. If a molecule was thought to be harmful, researchers might try to develop a drug to block it entirely. But Zhu’s new work highlights the downside of that shotgun approach. A molecule might be causing problems because of what it’s doing in one part of the cell, but, at the same time, that same molecule is doing something entirely different in other parts — perhaps something tremendously important. So shutting it down entirely would be like trying to solve the problem of traffic congestion by banning cars.
Now, rather than crudely trying to block a molecule regardless of its many functions, doctors can target a specific molecule doing a specific thing in a specific location. That adds a new level of precision to the concept of precision medicine – medicine tailored exactly to a patient’s needs.
Safer Drugs and Medicines
Zhu, of UVA’s Department of Pharmacology, thinks the technique will be useful for many different diseases, but especially for cancers and neurological conditions such as autism and Alzheimer’s. Those, in particular, will benefit from a better understanding of what molecules at what locations would make good targets, he and his colleagues note in a new paper sharing their technique with other scientists.
The technique will also speed up the development of new treatments by letting researchers more quickly understand what molecules are doing and which should be targeted.
“The idea [behind the technique] is actually very simple,” Zhu said. “But it took us a lot of years to make this thing work.”
The Latest on: Drugs with no side effects
via Google News
The Latest on: Drugs with no side effects
- ‘Buprenorphine most successful medicine. Can be used for years without side-effects’on August 16, 2019 at 8:53 pm
How many prisoners are getting treated for drug de-addiction in Amritsar central ... which can be used for a very long time. There is no side-effect. The latest concept is that a patient is ...
- EmphyCorp Inc. FDA Submission for Rx New Non-Steroidal Nasal Spray for Pulmonary Fibrosis w/ No Known Side Effectson August 15, 2019 at 7:08 am
EmphyCorp has a Pipeline of Global Patented Rx Technology that includes Orphan Drug Designations for ... Non-Steroidal Rx Technology with no Known Side Effects to penetrate the Chronic Breathing ...
- Follow health care provider's guidelines to reduce risk of side effects from anesthesiaon August 8, 2019 at 3:20 am
By having this conversation, and following the guidelines you're given about eating, drinking and taking medications before your procedure, you can significantly reduce your risk of complications and ...
- People with intellectual disabilities are often not told about their medicines and their potential side effectson August 1, 2019 at 6:12 am
As a result, they often don’t understand the drugs prescribed for them or their potential side effects. The Accessible Information Standard states that all organisations providing NHS care and ...
- Podcast: Sexual Side Effects Caused by Psychiatric Medicationson July 30, 2019 at 5:00 pm
Gabe: No, no, say it again. Lisa ... Specifically this show is about the sexual side effects of psychiatric medications. We just tabled it by masturbation because that’s really how people figure it ...
- Side effects risk of some flea and tick medicationson July 22, 2019 at 8:00 pm
Nexgard says it’s become the number one selling dog flea and tick drug in the U.S. But the troubling side effects of these drugs ... million dollars in 2018. No one at the Zoetis offices would ...
- Stanford AI can predict negative side effects of millions of drug combinationson July 11, 2019 at 5:00 pm
... whether pairs of drugs will cause adverse side effects(Credit: everythingposs/Depositphotos) When a doctor prescribes a patient more than one drug simultaneously, they currently have virtually no ...
- PETER J. PITTS: Drug bill carries serious side-effects, no benefitson July 10, 2019 at 10:20 pm
Sens. John Cornyn (R-TX) and Richard Blumenthal (D-CT) claim that their new bill — the Affordable Prescriptions for Patients Act — will expand access to needed medicines for American patients. But in ...
- Gut Bacteria Consume Parkinson’s Drug Levodopa, Often with Harmful Side Effectson June 27, 2019 at 3:56 am
“Gut microbes can chew up medications, too, often with hazardous side effects,” said study first author Vayu Maini ... even for chemists,” they said. “There’s no way to do it on the bench top, and ...
via Bing News